PDB: 414 件ウェブページステータス検索Chemie searchBIRD

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8SM5	Crystal Structure of BHRF1 from Epstein Barr Virus in complex with BID BH3 peptide 分子名称: Apoptosis regulator BHRF1, BID BH3 著者 Wyatt, S, Sinha, S. 登録日 2023-04-25 公開日 2023-10-11 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (2.61002612 Å) 主引用文献 Epstein-Barr Virus Encoded BCL2, BHRF1, Downregulates Autophagy by Noncanonical Binding of BECN1. Biochemistry, 62, 2023
8SPF	Crystal structure of Bax core domain BH3-groove dimer - hexameric fraction with 2-stearoyl lysoPC 分子名称: 1,2-ETHANEDIOL, Apoptosis regulator BAX, DODECANE, ... 著者 Cowan, A.D, Miller, M.S, Czabotar, P.E, Colman, P.M. 登録日 2023-05-03 公開日 2023-12-27 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Sequence differences between BAX and BAK core domains manifest as differences in their interactions with lipids. Febs J., 2023
8SPE	Crystal structure of Bax core domain BH3-groove dimer - tetrameric fraction P31 分子名称: 1,2-ETHANEDIOL, Apoptosis regulator BAX, DI(HYDROXYETHYL)ETHER, ... 著者 Miller, M.S, Cowan, A.D, Colman, P.M, Czabotar, P.E. 登録日 2023-05-03 公開日 2023-12-27 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Sequence differences between BAX and BAK core domains manifest as differences in their interactions with lipids. Febs J., 2023
8SPZ	Crystal structure of Bax core domain BH3-groove dimer - hexameric fraction with dioctanoyl phosphatidylserine 分子名称: Apoptosis regulator BAX, SULFATE ION 著者 Cowan, A.D, Colman, P.M, Czabotar, P.E, Miller, M.S. 登録日 2023-05-04 公開日 2023-12-27 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Sequence differences between BAX and BAK core domains manifest as differences in their interactions with lipids. Febs J., 2023
8SRX	Crystal structure of BAK-BAX heterodimer with lysoPC 分子名称: 1,2-ETHANEDIOL, Apoptosis regulator BAX, Bcl-2 homologous antagonist/killer, ... 著者 Brouwer, J.M, Czabotar, P.E, Colman, P.M, Miller, M.S. 登録日 2023-05-07 公開日 2023-12-27 実験手法 X-RAY DIFFRACTION (2.09 Å) 主引用文献 Sequence differences between BAX and BAK core domains manifest as differences in their interactions with lipids. Febs J., 2023
8SRY	Crystal structure of BAK-BAX heterodimer with C12E8 分子名称: 2-(2-METHOXYETHOXY)ETHANOL, 3,6,9,12,15,18-HEXAOXAICOSANE-1,20-DIOL, 3,6,9,12,15-PENTAOXATRICOSAN-1-OL, ... 著者 Brouwer, J.M, Czabotar, P.E, Colman, P.M, Miller, M.S. 登録日 2023-05-08 公開日 2023-12-27 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Sequence differences between BAX and BAK core domains manifest as differences in their interactions with lipids. Febs J., 2023
8SVK	Crystal structure of Bax D71N core domain BH3-groove dimer 分子名称: Apoptosis regulator BAX, DI(HYDROXYETHYL)ETHER, SULFATE ION, ... 著者 Miller, M.S, Czabotar, P.E, Colman, P.M. 登録日 2023-05-16 公開日 2023-12-27 実験手法 X-RAY DIFFRACTION (2.25 Å) 主引用文献 Sequence differences between BAX and BAK core domains manifest as differences in their interactions with lipids. Febs J., 2023
8SVY	MBP-Mcl1 in complex with ligand 10 分子名称: (15P)-17-chloro-33-fluoro-12-[(2-methoxyethoxy)methyl]-5,14,22-trimethyl-28-oxa-9-thia-5,6,13,14,22-pentaazaheptacyclo[27.7.1.1~4,7~.0~11,15~.0~16,21~.0~20,24~.0~30,35~]octatriaconta-1(36),4(38),6,11(15),12,16,18,20,23,29(37),30,32,34-tridecaene-23-carboxylic acid, 1,2-ETHANEDIOL, GLYCEROL, ... 著者 Miller, B.R, Shaffer, P. 登録日 2023-05-17 公開日 2023-08-09 最終更新日 2024-05-22 実験手法 X-RAY DIFFRACTION (1.47 Å) 主引用文献 Macrocyclic Carbon-Linked Pyrazoles As Novel Inhibitors of MCL-1. Acs Med.Chem.Lett., 14, 2023
8U27	Bcl-2-xL complexed with compound 35 分子名称: Apoptosis regulator Bcl-2, Bcl-2-like protein 1 chimera, propan-2-yl {4-[(5S)-1-(4-bromobenzoyl)-5-phenyl-4,5-dihydro-1H-pyrazol-3-yl]phenyl}carbamate 著者 Rizo, J, Pan, Y.-Z. 登録日 2023-09-05 公開日 2023-09-13 最終更新日 2024-05-15 実験手法 SOLUTION NMR 主引用文献 Structural insights for selective disruption of Beclin 1 binding to Bcl-2. Commun Biol, 6, 2023
8WLS	Bcl-xL in complex with HBx BH3 delta C peptide 分子名称: Bcl-2-like protein 1, Protein X 著者 Kobayashi, N, Nagata, T, Kusunoki, H. 登録日 2023-10-01 公開日 2024-03-20 最終更新日 2024-05-15 実験手法 SOLUTION NMR 主引用文献 Structural Insights into the Interaction between the C-Terminal-Deleted BH3-like Motif Peptide of Hepatitis B Virus X Protein and Bcl-x L. Biochemistry, 63, 2024
8QSO	Crystal structure of human Mcl-1 in complex with compound 1 分子名称: (13S,16R,19S)-16-benzyl-43-ethoxy-N-methyl-7,11,14,17-tetraoxo-13-phenyl-5-oxa-2,8,12,15,18-pentaaza-1(1,4),4(1,2)-dibenzena-9(1,4)-cyclohexanacycloicosaphane-19-carboxamide, Maltose/maltodextrin-binding periplasmic protein,Induced myeloid leukemia cell differentiation protein Mcl-1, alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose 著者 Hekking, K.F.W, Gremmen, S, Maroto, S, Keefe, A.D, Zhang, Y. 登録日 2023-10-10 公開日 2024-02-14 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (2.106 Å) 主引用文献 Development of Potent Mcl-1 Inhibitors: Structural Investigations on Macrocycles Originating from a DNA-Encoded Chemical Library Screen. J.Med.Chem., 67, 2024
8UKY	Crystal structure of BAK in complex with inhibiting antibody 14G6 分子名称: 1,2-ETHANEDIOL, 14G6 Fab heavy chain, 14G6 Fab light chain, ... 著者 Miller, M.S, Czabotar, P.E. 登録日 2023-10-15 公開日 2024-04-10 最終更新日 2024-04-17 実験手法 X-RAY DIFFRACTION (2.398 Å) 主引用文献 A novel inhibitory BAK antibody enables assessment of non-activated BAK in cancer cells. Cell Death Differ., 2024
8XP5	The Crystal Structure of p53/BCL-xL fusion complex from Biortus. 分子名称: Bcl-2-like protein 1,Cellular tumor antigen p53, ZINC ION 著者 Wang, F, Cheng, W, Yuan, Z, Lin, D, Bao, C. 登録日 2024-01-03 公開日 2024-03-06 実験手法 X-RAY DIFFRACTION (2.55 Å) 主引用文献 The Crystal Structure of p53/BCL-xL fusion complex from Biortus. To Be Published
8VJP	Histidine-covalent stapled alpha-helical peptide (155H1) targeting hMcl-1 分子名称: (4Z)-oct-4-en-1-ol, (S~1~R)-3-carbamoyl-4-methoxybenzene-1-sulfinic acid, Histidine-covalent stapled alpha-helical peptide, ... 著者 Muzzarelli, K.M, Assar, Z, Alboreggia, G, Pellecchia, M. 登録日 2024-01-07 公開日 2024-05-15 最終更新日 2024-06-05 実験手法 X-RAY DIFFRACTION (1.13 Å) 主引用文献 Histidine-Covalent Stapled Alpha-Helical Peptides Targeting hMcl-1. J.Med.Chem., 67, 2024

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