5LQH
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7RCU
| Synthetic Max homodimer mimic in complex with DNA | 分子名称: | 2'-DEOXYADENOSINE-5'-MONOPHOSPHATE, 2-(2,5-dioxopyrrolidin-1-yl)acetamide, ACETAMIDE, ... | 著者 | Speltz, T, Qiao, Z, Shangguan, S, Fanning, S, Greene, J, Moellering, R. | 登録日 | 2021-07-08 | 公開日 | 2022-09-14 | 最終更新日 | 2024-05-29 | 実験手法 | X-RAY DIFFRACTION (2.69 Å) | 主引用文献 | Targeting MYC with modular synthetic transcriptional repressors derived from bHLH DNA-binding domains. Nat.Biotechnol., 41, 2023
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6MHE
| Galphai3 co-crystallized with KB752 | 分子名称: | GLYCEROL, GUANOSINE-5'-DIPHOSPHATE, Guanine nucleotide-binding protein G(k) subunit alpha, ... | 著者 | Rees, S.D, Kalogriopoulos, N.A, Ngo, T, Kopcho, N, Ilatovskiy, A, Sun, N, Komives, E, Chang, G, Ghosh, P, Kufareva, I. | 登録日 | 2018-09-17 | 公開日 | 2019-07-31 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Structural basis for GPCR-independent activation of heterotrimeric Gi proteins. Proc.Natl.Acad.Sci.USA, 116, 2019
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7XEM
| Cholesterol bound state of mTRPV2 | 分子名称: | CHOLESTEROL, Transient receptor potential cation channel subfamily V member 2 | 著者 | Su, N. | 登録日 | 2022-03-31 | 公開日 | 2022-08-17 | 最終更新日 | 2024-06-26 | 実験手法 | ELECTRON MICROSCOPY (3.17 Å) | 主引用文献 | Structural mechanisms of TRPV2 modulation by endogenous and exogenous ligands. Nat.Chem.Biol., 19, 2023
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7XEU
| Structure of mTRPV2_E2 | 分子名称: | CHOLESTEROL, Transient receptor potential cation channel subfamily V member 2 | 著者 | Su, N. | 登録日 | 2022-03-31 | 公開日 | 2022-08-17 | 最終更新日 | 2024-07-03 | 実験手法 | ELECTRON MICROSCOPY (2.77 Å) | 主引用文献 | Structural mechanisms of TRPV2 modulation by endogenous and exogenous ligands. Nat.Chem.Biol., 19, 2023
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7XEO
| MbetaCD treated state of mTRPV2 | 分子名称: | Transient receptor potential cation channel subfamily V member 2 | 著者 | Su, N. | 登録日 | 2022-03-31 | 公開日 | 2022-08-17 | 最終更新日 | 2024-06-26 | 実験手法 | ELECTRON MICROSCOPY (2.89 Å) | 主引用文献 | Structural mechanisms of TRPV2 modulation by endogenous and exogenous ligands. Nat.Chem.Biol., 19, 2023
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6MMR
| Diheteromeric NMDA receptor GluN1/GluN2A in the '2-Knuckle-Symmetric' conformation, in complex with glycine and glutamate, in the presence of 1 millimolar zinc chloride, 3 millimolar EDTA, and at pH 7.4 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Glutamate receptor ionotropic, NMDA 1, ... | 著者 | Jalali-Yazdi, F, Chowdhury, S, Yoshioka, C, Gouaux, E. | 登録日 | 2018-10-01 | 公開日 | 2018-11-28 | 最終更新日 | 2020-07-29 | 実験手法 | ELECTRON MICROSCOPY (5.13 Å) | 主引用文献 | Mechanisms for Zinc and Proton Inhibition of the GluN1/GluN2A NMDA Receptor. Cell, 175, 2018
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7XEV
| Structure of mTRPV2_2-APB | 分子名称: | 2-aminoethyl diphenylborinate, Transient receptor potential cation channel subfamily V member 2 | 著者 | Su, N. | 登録日 | 2022-03-31 | 公開日 | 2022-08-17 | 最終更新日 | 2024-07-03 | 実験手法 | ELECTRON MICROSCOPY (3.27 Å) | 主引用文献 | Structural mechanisms of TRPV2 modulation by endogenous and exogenous ligands. Nat.Chem.Biol., 19, 2023
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6MMB
| Diheteromeric NMDA receptor GluN1/GluN2A in the 'Super-Splayed' conformation, in complex with glycine and glutamate, in the presence of 1 micromolar zinc chloride, and at pH 6.1 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Glutamate receptor ionotropic, NMDA 1, ... | 著者 | Jalali-Yazdi, F, Chowdhury, S, Yoshioka, C, Gouaux, E. | 登録日 | 2018-09-30 | 公開日 | 2018-11-28 | 最終更新日 | 2020-07-29 | 実験手法 | ELECTRON MICROSCOPY (12.7 Å) | 主引用文献 | Mechanisms for Zinc and Proton Inhibition of the GluN1/GluN2A NMDA Receptor. Cell, 175, 2018
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6MGQ
| ERAP1 in the open conformation bound to 10mer phosphinic inhibitor DG014 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Endoplasmic reticulum aminopeptidase 1, Phosphinic inhibitor DG014, ... | 著者 | Stern, L.J, Maben, Z. | 登録日 | 2018-09-14 | 公開日 | 2019-12-18 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.92 Å) | 主引用文献 | Conformational dynamics linked to domain closure and substrate binding explain the ERAP1 allosteric regulation mechanism. Nat Commun, 12, 2021
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7XER
| Structure of mTRPV2_Q525T | 分子名称: | CHOLESTEROL, Transient receptor potential cation channel subfamily V member 2 | 著者 | Su, N. | 登録日 | 2022-03-31 | 公開日 | 2022-08-17 | 最終更新日 | 2024-06-26 | 実験手法 | ELECTRON MICROSCOPY (2.47 Å) | 主引用文献 | Structural mechanisms of TRPV2 modulation by endogenous and exogenous ligands. Nat.Chem.Biol., 19, 2023
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6MMS
| Triheteromeric NMDA receptor GluN1/GluN2A/GluN2A* in the '2-Knuckle-Symmetric' conformation, in complex with glycine and glutamate, in the presence of 1 millimolar EDTA, and at pH 7.4 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Glutamate receptor ionotropic, ... | 著者 | Jalali-Yazdi, F, Chowdhury, S, Yoshioka, C, Gouaux, E. | 登録日 | 2018-10-01 | 公開日 | 2018-11-28 | 最終更新日 | 2020-07-29 | 実験手法 | ELECTRON MICROSCOPY (5.38 Å) | 主引用文献 | Mechanisms for Zinc and Proton Inhibition of the GluN1/GluN2A NMDA Receptor. Cell, 175, 2018
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7XEW
| Structure of mTRPV2_Q525F | 分子名称: | Transient receptor potential cation channel subfamily V member 2 | 著者 | Su, N. | 登録日 | 2022-03-31 | 公開日 | 2022-08-17 | 最終更新日 | 2024-07-03 | 実験手法 | ELECTRON MICROSCOPY (2.59 Å) | 主引用文献 | Structural mechanisms of TRPV2 modulation by endogenous and exogenous ligands. Nat.Chem.Biol., 19, 2023
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6MHM
| Crystal structure of human acid ceramidase in covalent complex with carmofur | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Dementiev, A, Joachimiak, A, Doan, N. | 登録日 | 2018-09-18 | 公開日 | 2019-01-23 | 最終更新日 | 2024-10-16 | 実験手法 | X-RAY DIFFRACTION (2.743 Å) | 主引用文献 | Molecular Mechanism of Inhibition of Acid Ceramidase by Carmofur. J. Med. Chem., 62, 2019
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7QZR
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6MMV
| Triheteromeric NMDA receptor GluN1/GluN2A/GluN2A* Extracellular Domain in the '2-Knuckle-Asymmetric' conformation, in complex with glycine and glutamate, in the presence of 1 micromolar zinc chloride, and at pH 7.4 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Glutamate receptor ionotropic, ... | 著者 | Jalali-Yazdi, F, Chowdhury, S, Yoshioka, C, Gouaux, E. | 登録日 | 2018-10-01 | 公開日 | 2018-11-28 | 最終更新日 | 2024-10-09 | 実験手法 | ELECTRON MICROSCOPY (4.71 Å) | 主引用文献 | Mechanisms for Zinc and Proton Inhibition of the GluN1/GluN2A NMDA Receptor. Cell, 175, 2018
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6ZKX
| Crystal structure of InhA:01 TCR in complex with HLA-E (Y84C) bound to InhA (53-61 GCG) | 分子名称: | 1,2-ETHANEDIOL, Beta-2-microglobulin, Enoyl-[acyl-carrier-protein] reductase [NADH], ... | 著者 | Srikannathasan, V, Karuppiah, V, Robinson, R.A. | 登録日 | 2020-06-30 | 公開日 | 2022-01-26 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (2.17 Å) | 主引用文献 | Structure-guided stabilization of pathogen-derived peptide-HLA-E complexes using non-natural amino acids conserves native TCR recognition. Eur.J.Immunol., 52, 2022
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6MMG
| Diheteromeric NMDA receptor GluN1/GluN2A in the '2-Knuckle-Symmetric' conformation, in complex with glycine and glutamate, in the presence of 1 millimolar EDTA, and at pH 7.4 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Glutamate receptor ionotropic, ... | 著者 | Jalali-Yazdi, F, Chowdhury, S, Yoshioka, C, Gouaux, E. | 登録日 | 2018-09-30 | 公開日 | 2018-11-28 | 最終更新日 | 2020-07-29 | 実験手法 | ELECTRON MICROSCOPY (6.23 Å) | 主引用文献 | Mechanisms for Zinc and Proton Inhibition of the GluN1/GluN2A NMDA Receptor. Cell, 175, 2018
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6MMX
| Triheteromeric NMDA receptor GluN1/GluN2A/GluN2A* in the 'Extended' conformation, in complex with glycine and glutamate, in the presence of 1 micromolar zinc chloride, and at pH 7.4 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Glutamate receptor ionotropic, ... | 著者 | Jalali-Yazdi, F, Chowdhury, S, Yoshioka, C, Gouaux, E. | 登録日 | 2018-10-01 | 公開日 | 2018-11-28 | 最終更新日 | 2020-07-29 | 実験手法 | ELECTRON MICROSCOPY (6.99 Å) | 主引用文献 | Mechanisms for Zinc and Proton Inhibition of the GluN1/GluN2A NMDA Receptor. Cell, 175, 2018
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6ZKZ
| Crystal structure of InhA:01 TCR in complex with HLA-E (F116C) bound to InhA (53-61 H4C) | 分子名称: | 1,2-ETHANEDIOL, Beta-2-microglobulin, Enoyl-[acyl-carrier-protein] reductase [NADH], ... | 著者 | Srikannathasan, V, Karuppiah, V, Robinson, R.A. | 登録日 | 2020-06-30 | 公開日 | 2022-01-26 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Structure-guided stabilization of pathogen-derived peptide-HLA-E complexes using non-natural amino acids conserves native TCR recognition. Eur.J.Immunol., 52, 2022
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6BXJ
| Structure of a single-chain beta3 integrin | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Chimera protein of Integrin beta-3 and Integrin alpha-L, MAGNESIUM ION | 著者 | Thinn, A.M.M, Wang, Z, Zhou, D, Zhao, Y, Curtis, B.R, Zhu, J. | 登録日 | 2017-12-18 | 公開日 | 2018-10-03 | 最終更新日 | 2024-10-09 | 実験手法 | X-RAY DIFFRACTION (2.092 Å) | 主引用文献 | Autonomous conformational regulation of beta3integrin and the conformation-dependent property of HPA-1a alloantibodies. Proc. Natl. Acad. Sci. U.S.A., 115, 2018
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6C4C
| Crystal structure of 3-nitropropionate modified isocitrate lyase from Mycobacterium tuberculosis with glyoxylate and pyruvate | 分子名称: | 3-NITROPROPANOIC ACID, GLYOXYLIC ACID, Isocitrate lyase 1, ... | 著者 | Kreitler, D.F, Ray, S, Murkin, A.S, Gulick, A.M. | 登録日 | 2018-01-11 | 公開日 | 2018-06-06 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | The Nitro Group as a Masked Electrophile in Covalent Enzyme Inhibition. ACS Chem. Biol., 13, 2018
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6ZKW
| Crystal structure of InhA:01 TCR in complex with HLA-E bound to InhA (53-61) | 分子名称: | Beta-2-microglobulin, Enoyl-[acyl-carrier-protein] reductase [NADH], HLA class I histocompatibility antigen, ... | 著者 | Srikannathasan, V, Karuppiah, V, Robinson, R.A. | 登録日 | 2020-06-30 | 公開日 | 2022-01-26 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (2.26 Å) | 主引用文献 | Structure-guided stabilization of pathogen-derived peptide-HLA-E complexes using non-natural amino acids conserves native TCR recognition. Eur.J.Immunol., 52, 2022
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5WOG
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6MHF
| Galphai3 co-crystallized with GIV/Girdin | 分子名称: | GLYCEROL, GUANOSINE-5'-DIPHOSPHATE, Girdin, ... | 著者 | Rees, S.D, Kalogriopoulos, N.A, Ngo, T, Kopcho, N, Ilatovskiy, A, Sun, N, Komives, E, Chang, G, Ghosh, P, Kufareva, I. | 登録日 | 2018-09-17 | 公開日 | 2019-07-31 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Structural basis for GPCR-independent activation of heterotrimeric Gi proteins. Proc.Natl.Acad.Sci.USA, 116, 2019
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