6MHE

Galphai3 co-crystallized with KB752

Summary for 6MHE

Entry DOI	10.2210/pdb6mhe/pdb
Descriptor	Guanine nucleotide-binding protein G(k) subunit alpha, KB752 peptide, GLYCEROL, ... (5 entities in total)
Functional Keywords	exchange, gpcr, inhibitory, signaling protein
Biological source	Rattus norvegicus (Rat) More
Total number of polymer chains	2
Total formula weight	42638.99
Authors	Rees, S.D.,Kalogriopoulos, N.A.,Ngo, T.,Kopcho, N.,Ilatovskiy, A.,Sun, N.,Komives, E.,Chang, G.,Ghosh, P.,Kufareva, I. (deposition date: 2018-09-17, release date: 2019-07-31, Last modification date: 2023-10-11)
Primary citation	Kalogriopoulos, N.A.,Rees, S.D.,Ngo, T.,Kopcho, N.J.,Ilatovskiy, A.V.,Sun, N.,Komives, E.A.,Chang, G.,Ghosh, P.,Kufareva, I. Structural basis for GPCR-independent activation of heterotrimeric Gi proteins. Proc.Natl.Acad.Sci.USA, 116:16394-16403, 2019 Cited by PubMed: 31363053 DOI: 10.1073/pnas.1906658116 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.2 Å)

Structure validation