4M1W
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![BU of 4m1w by Molmil](/molmil-images/mine/4m1w) | Crystal Structure of small molecule vinylsulfonamide covalently bound to K-Ras G12C | 分子名称: | GUANOSINE-5'-DIPHOSPHATE, K-Ras GTPase, MAGNESIUM ION, ... | 著者 | Ostrem, J.M, Peters, U, Sos, M.L, Wells, J.A, Shokat, K.M. | 登録日 | 2013-08-04 | 公開日 | 2013-11-27 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (1.58 Å) | 主引用文献 | K-Ras(G12C) inhibitors allosterically control GTP affinity and effector interactions. Nature, 503, 2013
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4LUP
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![BU of 4lup by Molmil](/molmil-images/mine/4lup) | Crystal structure of the complex formed by region of E. coli sigmaE bound to its -10 element non template strand | 分子名称: | 1,2-ETHANEDIOL, RNA polymerase sigma factor, region 2 of sigmaE of E. coli | 著者 | Campagne, S, Marsh, M.E, Vorholt, J.A.V, Allain, F.H.-T, Capitani, G. | 登録日 | 2013-07-25 | 公開日 | 2014-02-19 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (1.2 Å) | 主引用文献 | Structural basis for -10 promoter element melting by environmentally induced sigma factors. Nat.Struct.Mol.Biol., 21, 2014
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4LZP
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4AOJ
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![BU of 4aoj by Molmil](/molmil-images/mine/4aoj) | Human TrkA in complex with the inhibitor AZ-23 | 分子名称: | 5-chloranyl-N2-[(1S)-1-(5-fluoranylpyridin-2-yl)ethyl]-N4-(3-propan-2-yloxy-1H-pyrazol-5-yl)pyrimidine-2,4-diamine, HIGH AFFINITY NERVE GROWTH FACTOR RECEPTOR, ZINC ION | 著者 | Wang, T, Lamb, M.L, Block, M.H, Davies, A.M, Han, Y, Hoffmann, E, Ioannidis, S, Josey, J.A, Liu, Z, Lyne, P.D, MacIntyre, T, Mohr, P.J, Omer, C.A, Sjogren, T, Thress, K, Wang, B, Wang, H, Yu, D, Zhang, H. | 登録日 | 2012-03-28 | 公開日 | 2012-08-15 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (2.75 Å) | 主引用文献 | Discovery of Disubstituted Imidazo[4,5-B]Pyridines and Purines as Potent Trka Inhibitors Acs Med.Chem.Lett., 3, 2012
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4NP8
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![BU of 4np8 by Molmil](/molmil-images/mine/4np8) | Structure of an amyloid forming peptide VQIVYK from the second repeat region of tau (alternate polymorph) | 分子名称: | Microtubule-associated protein tau | 著者 | Landau, M, Eisenberg, D, Sawaya, M.R, Dannenberg, J, Kobko, N. | 登録日 | 2013-11-20 | 公開日 | 2013-12-18 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (1.51 Å) | 主引用文献 | Molecular mechanisms for protein-encoded inheritance. Nat.Struct.Mol.Biol., 16, 2009
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4E2R
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3KKA
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![BU of 3kka by Molmil](/molmil-images/mine/3kka) | Co-crystal structure of the sam domains of EPHA1 AND EPHA2 | 分子名称: | CHLORIDE ION, EPHRIN TYPE-A RECEPTOR 1, EPHRIN TYPE-A RECEPTOR 2 | 著者 | Walker, J.R, Yermekbayeva, L, Butler-Cole, C, Weigelt, J, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Bochkarev, A, Dhe-Paganon, S, Structural Genomics Consortium (SGC) | 登録日 | 2009-11-05 | 公開日 | 2009-11-24 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Co-Crystal Structure of the SAM Domains of Human Ephrin Type-A Receptor 1 and Human Ephrin Type-A Receptor 2 To be Published
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4ACV
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3KFL
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![BU of 3kfl by Molmil](/molmil-images/mine/3kfl) | Leishmania major methionyl-tRNA synthetase in complex with methionyladenylate and pyrophosphate | 分子名称: | 1,2-ETHANEDIOL, FORMIC ACID, MAGNESIUM ION, ... | 著者 | Larson, E.T, Merritt, E.A, Medical Structural Genomics of Pathogenic Protozoa (MSGPP) | 登録日 | 2009-10-27 | 公開日 | 2010-10-27 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Structure of Leishmania major methionyl-tRNA synthetase in complex with intermediate products methionyladenylate and pyrophosphate. Biochimie, 93, 2011
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3KB7
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![BU of 3kb7 by Molmil](/molmil-images/mine/3kb7) | Crystal structure of Polo-like kinase 1 in complex with a pyrazoloquinazoline inhibitor | 分子名称: | 8-{[2-methoxy-5-(4-methylpiperazin-1-yl)phenyl]amino}-1-methyl-4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline-3-carboxamide, L(+)-TARTARIC ACID, Serine/threonine-protein kinase PLK1, ... | 著者 | Bossi, R.T, Bertrand, J.A. | 登録日 | 2009-10-20 | 公開日 | 2010-05-19 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Identification of 4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline derivatives as a new class of orally and selective Polo-like kinase 1 inhibitors J.Med.Chem., 53, 2010
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4NVR
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![BU of 4nvr by Molmil](/molmil-images/mine/4nvr) | 2.22 Angstrom Resolution Crystal Structure of a Putative Acyltransferase from Salmonella enterica | 分子名称: | CALCIUM ION, CHLORIDE ION, Putative acyltransferase | 著者 | Minasov, G, Wawrzak, Z, Skarina, T, Gordon, E, Stam, J, Kwon, K, Savchenko, A, Anderson, W.F, Center for Structural Genomics of Infectious Diseases (CSGID) | 登録日 | 2013-12-05 | 公開日 | 2013-12-18 | 最終更新日 | 2017-11-22 | 実験手法 | X-RAY DIFFRACTION (2.22 Å) | 主引用文献 | 2.22 Angstrom Resolution Crystal Structure of a Putative Acyltransferase from Salmonella enterica. TO BE PUBLISHED
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4NPD
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![BU of 4npd by Molmil](/molmil-images/mine/4npd) | High-resolution structure of C domain of staphylococcal protein A at cryogenic temperature | 分子名称: | Immunoglobulin G-binding protein A, THIOCYANATE ION, ZINC ION | 著者 | Deis, L.N, Pemble IV, C.W, Oas, T.G, Richardson, J.S, Richardson, D.C. | 登録日 | 2013-11-21 | 公開日 | 2014-10-08 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (0.9 Å) | 主引用文献 | Multiscale conformational heterogeneity in staphylococcal protein a: possible determinant of functional plasticity. Structure, 22, 2014
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3KHQ
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4A8A
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![BU of 4a8a by Molmil](/molmil-images/mine/4a8a) | Asymmetric cryo-EM reconstruction of E. coli DegQ 12-mer in complex with lysozyme | 分子名称: | LYSOZYME C, PERIPLASMIC PH-DEPENDENT SERINE ENDOPROTEASE DEGQ | 著者 | Malet, H, Canellas, F, Sawa, J, Yan, J, Thalassinos, K, Ehrmann, M, Clausen, T, Saibil, H.R. | 登録日 | 2011-11-20 | 公開日 | 2011-12-28 | 最終更新日 | 2024-05-08 | 実験手法 | ELECTRON MICROSCOPY (14.2 Å) | 主引用文献 | Newly Folded Substrates Inside the Molecular Cage of the Htra Chaperone Degq Nat.Struct.Mol.Biol., 19, 2012
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3KGB
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4NQV
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4A2Y
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![BU of 4a2y by Molmil](/molmil-images/mine/4a2y) | STRUCTURE OF THE HUMAN EOSINOPHIL CATIONIC PROTEIN IN COMPLEX WITH CITRATE ANIONS | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, CITRIC ACID, EOSINOPHIL CATIONIC PROTEIN | 著者 | Boix, E, Pulido, D, Moussaoui, M, Nogues, V, Russi, S. | 登録日 | 2011-09-29 | 公開日 | 2012-06-27 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | The Sulfate-Binding Site Structure of the Human Eosinophil Cationic Protein as Revealed by a New Crystal Form. J.Struct.Biol., 179, 2012
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3KBH
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![BU of 3kbh by Molmil](/molmil-images/mine/3kbh) | Crystal structure of NL63 respiratory coronavirus receptor-binding domain complexed with its human receptor | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Angiotensin-converting enzyme 2, Spike glycoprotein | 著者 | Wu, K, Li, W, Peng, G, Li, F. | 登録日 | 2009-10-20 | 公開日 | 2009-12-15 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (3.31 Å) | 主引用文献 | Crystal structure of NL63 respiratory coronavirus receptor-binding domain complexed with its human receptor. Proc.Natl.Acad.Sci.USA, 106, 2009
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4EC7
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![BU of 4ec7 by Molmil](/molmil-images/mine/4ec7) | Cobra NGF in complex with lipid | 分子名称: | (2S)-1-hydroxy-3-(tetradecanoyloxy)propan-2-yl docosanoate, Venom nerve growth factor | 著者 | Jiang, T, Wang, F, Tong, Q. | 登録日 | 2012-03-26 | 公開日 | 2012-09-12 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Structural and functional insights into lipid-bound nerve growth factors Faseb J., 26, 2012
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4NYF
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![BU of 4nyf by Molmil](/molmil-images/mine/4nyf) | HIV integrase in complex with inhibitor | 分子名称: | (2S)-tert-butoxy[4-(4-chlorophenyl)-2-methylquinolin-3-yl]ethanoic acid, CADMIUM ION, Integrase | 著者 | Coulombe, R, Fader, L. | 登録日 | 2013-12-10 | 公開日 | 2014-06-25 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Discovery of BI 224436, a Noncatalytic Site Integrase Inhibitor (NCINI) of HIV-1. ACS Med Chem Lett, 5, 2014
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446D
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![BU of 446d by Molmil](/molmil-images/mine/446d) | STRUCTURE OF THE OLIGONUCLEOTIDE D(CGTATATACG) AS A SITE SPECIFIC COMPLEX WITH NICKEL IONS | 分子名称: | DNA (5'-D(*CP*GP*TP*AP*TP*AP*TP*AP*CP*G)-3'), NICKEL (II) ION | 著者 | Abrescia, N.G.A, Malinina, L, Gonzaga, L.F, Huynh-Dinh, T, Neidle, S, Subirana, J.A. | 登録日 | 1999-01-15 | 公開日 | 1999-03-18 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | Structure of the oligonucleotide d(CGTATATACG) as a site-specific complex with nickel ions. Nucleic Acids Res., 27, 1999
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4O22
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![BU of 4o22 by Molmil](/molmil-images/mine/4o22) | Binary complex of metal-free PKAc with SP20. | 分子名称: | Phosphorylated peptide pSP20., cAMP-dependent protein kinase catalytic subunit alpha. | 著者 | Das, A, Kovalevsky, A.Y, Gerlits, O, Langan, P, Heller, W.T, Keshwani, M, Taylor, S.S. | 登録日 | 2013-12-16 | 公開日 | 2014-05-28 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Metal-Free cAMP-Dependent Protein Kinase Can Catalyze Phosphoryl Transfer. Biochemistry, 53, 2014
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4O2D
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3KM5
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![BU of 3km5 by Molmil](/molmil-images/mine/3km5) | Crystal Structure Analysis of the K2 Cleaved Adhesin Domain of Lys-gingipain (Kgp) | 分子名称: | CALCIUM ION, GLYCEROL, Lysine specific cysteine protease, ... | 著者 | Li, N, Collyer, C.A, Hunter, N. | 登録日 | 2009-11-09 | 公開日 | 2010-03-31 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | 主引用文献 | Structure determination and analysis of a haemolytic gingipain adhesin domain from Porphyromonas gingivalis Mol.Microbiol., 76, 2010
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4A1Z
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![BU of 4a1z by Molmil](/molmil-images/mine/4a1z) | Eg5-1 | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, KINESIN-LIKE PROTEIN KIF11, MAGNESIUM ION, ... | 著者 | Talapatra, S.K, Kozielski, F. | 登録日 | 2011-09-20 | 公開日 | 2012-10-31 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | The Mitotic Kinesin Eg5 Overcomes Inhibition to the Phase I/II Clinical Candidate Sb743921 by an Allosteric Resistance Mechanism. J.Med.Chem., 56, 2013
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