3KFL

Leishmania major methionyl-tRNA synthetase in complex with methionyladenylate and pyrophosphate

Summary for 3KFL

Entry DOI	10.2210/pdb3kfl/pdb
Descriptor	Methionyl-tRNA synthetase, [[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxy-oxolan-2-yl]methoxy-hydroxy-phosphoryl] (2S)-2-azanyl-4-methylsulfanyl-butanoate, PYROPHOSPHATE 2-, ... (8 entities in total)
Functional Keywords	leishmania, parasite, aminoacyl-trna synthetase, trna ligase, aars, metrs, methionine, translation, atp-binding, nucleotide-binding, structural genomics, msgpp, ligase, medical structural genomics of pathogenic protozoa
Biological source	Leishmania major
Total number of polymer chains	1
Total formula weight	65347.46
Authors	Larson, E.T.,Merritt, E.A.,Medical Structural Genomics of Pathogenic Protozoa (MSGPP) (deposition date: 2009-10-27, release date: 2010-10-27, Last modification date: 2023-09-06)
Primary citation	Larson, E.T.,Kim, J.E.,Zucker, F.H.,Kelley, A.,Mueller, N.,Napuli, A.J.,Verlinde, C.L.,Fan, E.,Buckner, F.S.,Van Voorhis, W.C.,Merritt, E.A.,Hol, W.G. Structure of Leishmania major methionyl-tRNA synthetase in complex with intermediate products methionyladenylate and pyrophosphate. Biochimie, 93:570-582, 2011 Cited by PubMed: 21144880 DOI: 10.1016/j.biochi.2010.11.015 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation