4LZP
Structure of the TIR domain of the immunosuppressor BtpA from Brucella
Summary for 4LZP
| Entry DOI | 10.2210/pdb4lzp/pdb |
| Related | 3H16 |
| Descriptor | Putative uncharacterized protein (1 entity in total) |
| Functional Keywords | tir domain, virulence factor immuno suppressor, myd88, membrane, immune system |
| Biological source | Brucella melitensis |
| Total number of polymer chains | 4 |
| Total formula weight | 79806.61 |
| Authors | Kaplan-turkoz, B.,O'callaghan, D.,Vergunst, A.,Terradot, L. (deposition date: 2013-08-01, release date: 2013-11-06, Last modification date: 2023-11-08) |
| Primary citation | Kaplan-turkoz, B.,Koelblen, T.,Felix, C.,Candusso, M.P.,O'callaghan, D.,Vergunst, A.C.,Terradot, L. Structure of the Toll/interleukin 1 receptor (TIR) domain of the immunosuppressive Brucella effector BtpA/Btp1/TcpB Febs Lett., 587:3412-3416, 2013 Cited by PubMed Abstract: BtpA/Btp1/TcpB is a virulence factor produced by Brucella species that possesses a Toll interleukin-1 receptor (TIR) domain. Once delivered into the host cell, BtpA interacts with MyD88 to interfere with TLR signalling and modulates microtubule dynamics. Here the crystal structure of the BtpA TIR domain at 3.15 Å is presented. The structure shows a dimeric arrangement of a canonical TIR domain, similar to the Paracoccus denitrificans Tir protein but secured by a unique long N-terminal α-tail that packs against the TIR:TIR dimer. Structure-based mutations and multi-angle light scattering experiments characterized the BtpA dimer conformation in solution. The structure of BtpA will help with studies to understand the mechanisms involved in its interactions with MyD88 and with microtubules. PubMed: 24076024DOI: 10.1016/j.febslet.2013.09.007 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (3.15 Å) |
Structure validation
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