4M1W
Crystal Structure of small molecule vinylsulfonamide covalently bound to K-Ras G12C
Summary for 4M1W
Entry DOI | 10.2210/pdb4m1w/pdb |
Related | 4L8G 4L9S 4L9W 4LPK 4LRW 4LUC 4LV6 4LYF 4LYH 4LYJ 4M1O 4M1S 4M1T 4M1Y 4M21 4M22 |
Descriptor | K-Ras GTPase, MAGNESIUM ION, N-{1-[N-(4,5-dichloro-2-ethylphenyl)glycyl]piperidin-4-yl}ethanesulfonamide, ... (5 entities in total) |
Functional Keywords | gtpase, gdp bound, small molecule inhibitor, covalent binder, signaling protein-inhibitor complex, signaling protein/inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Cell membrane ; Lipid-anchor ; Cytoplasmic side : P01116 |
Total number of polymer chains | 3 |
Total formula weight | 60679.37 |
Authors | Ostrem, J.M.,Peters, U.,Sos, M.L.,Wells, J.A.,Shokat, K.M. (deposition date: 2013-08-04, release date: 2013-11-27, Last modification date: 2023-09-20) |
Primary citation | Ostrem, J.M.,Peters, U.,Sos, M.L.,Wells, J.A.,Shokat, K.M. K-Ras(G12C) inhibitors allosterically control GTP affinity and effector interactions. Nature, 503:548-551, 2013 Cited by PubMed: 24256730DOI: 10.1038/nature12796 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.58 Å) |
Structure validation
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