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4M1Y

Crystal Structure of small molecule vinylsulfonamide 15 covalently bound to K-Ras G12C

Summary for 4M1Y
Entry DOI10.2210/pdb4m1y/pdb
Related4L8G 4L9S 4L9W 4LPK 4LRW 4LUC 4LV6 4LYF 4LYH 4LYJ 4M1O 4M1S 4M1T 4M1W 4M21 4M22
DescriptorK-Ras GTPase, GUANOSINE-5'-DIPHOSPHATE, N-{1-[N-(5,7-dichloro-2,1,3-benzothiadiazol-4-yl)glycyl]piperidin-4-yl}ethanesulfonamide, ... (4 entities in total)
Functional Keywordsgtpase, gdp bound, small molecule inhibitor, covalent binder, signaling protein-inhibitor complex, signaling protein/inhibitor
Biological sourceHomo sapiens (human)
Cellular locationCell membrane ; Lipid-anchor ; Cytoplasmic side : P01116
Total number of polymer chains3
Total formula weight59840.34
Authors
Ostrem, J.M.,Peters, U.,Sos, M.L.,Wells, J.A.,Shokat, K.M. (deposition date: 2013-08-04, release date: 2013-11-27, Last modification date: 2023-09-20)
Primary citationOstrem, J.M.,Peters, U.,Sos, M.L.,Wells, J.A.,Shokat, K.M.
K-Ras(G12C) inhibitors allosterically control GTP affinity and effector interactions.
Nature, 503:548-551, 2013
Cited by
PubMed: 24256730
DOI: 10.1038/nature12796
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.491 Å)
Structure validation

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