4L9S

Crystal Structure of H-Ras G12C, GDP-bound

Summary for 4L9S

• Entry DOI: 10.2210/pdb4l9s/pdb
• Related: 4L8G 4L9W 4LPK 4LRW 4LUC 4LV6 4LYF 4LYH 4LYJ 4M1O 4M1S 4M1T 4M1W 4M1Y 4M21 4M22
• Descriptor: GTPase HRas, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... (6 entities in total)
• Functional Keywords: gtpase, activating mutant, signaling protein
• Biological source: Homo sapiens (human)
• Cellular location: Cell membrane. Isoform 2: Nucleus: P01112
• Total number of polymer chains: 1
• Total formula weight: 19918.38

Authors

Ostrem, J.M.,Peters, U.,Sos, M.L.,Wells, J.A.,Shokat, K.M. (deposition date: 2013-06-18, release date: 2013-11-27, Last modification date: 2023-09-20)

• Primary citation: Ostrem, J.M.,Peters, U.,Sos, M.L.,Wells, J.A.,Shokat, K.M.; K-Ras(G12C) inhibitors allosterically control GTP affinity and effector interactions.; Nature, 503:548-551, 2013; PubMed: 24256730; DOI: 10.1038/nature12796

Experimental method

X-RAY DIFFRACTION (1.606 Å)