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4LYF

Crystal Structure of small molecule vinylsulfonamide 8 covalently bound to K-Ras G12C

Summary for 4LYF
Entry DOI10.2210/pdb4lyf/pdb
Related4L8G 4L9S 4L9W 4LPK 4LRW 4LUC 4LV6 4LYH 4LYJ 4M1O 4M1S 4M1T 4M1W 4M1Y 4M21 4M22
DescriptorGTPase KRas, GUANOSINE-5'-DIPHOSPHATE, N-{1-[N-(4,5-dichloro-2-hydroxyphenyl)glycyl]piperidin-4-yl}ethanesulfonamide, ... (4 entities in total)
Functional Keywordsgtpase, gdp bound, small molecule inhibitor, covalent binder, signaling protein-inhibitor complex, signaling protein/inhibitor
Biological sourceHomo sapiens (human)
Cellular locationCell membrane ; Lipid-anchor ; Cytoplasmic side : P01116
Total number of polymer chains3
Total formula weight59798.27
Authors
Ostrem, J.M.,Peters, U.,Sos, M.L.,Wells, J.A.,Shokat, K.M. (deposition date: 2013-07-31, release date: 2013-11-27, Last modification date: 2017-11-15)
Primary citationOstrem, J.M.,Peters, U.,Sos, M.L.,Wells, J.A.,Shokat, K.M.
K-Ras(G12C) inhibitors allosterically control GTP affinity and effector interactions.
Nature, 503:548-551, 2013
Cited by
PubMed: 24256730
DOI: 10.1038/nature12796
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.568 Å)
Structure validation

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