8K20
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8k20 by Molmil](/molmil-images/mine/8k20) | Cryo-EM structure of KEOPS complex from Arabidopsis thaliana | 分子名称: | At4g34412, At5g53043, FE (III) ION, ... | 著者 | Zheng, X.X, Zhu, L, Duan, L, Zhang, W.H. | 登録日 | 2023-07-11 | 公開日 | 2024-04-03 | 最終更新日 | 2024-05-22 | 実験手法 | ELECTRON MICROSCOPY (3.7 Å) | 主引用文献 | Molecular basis of A. thaliana KEOPS complex in biosynthesizing tRNA t6A. Nucleic Acids Res., 52, 2024
|
|
8I0L
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8i0l by Molmil](/molmil-images/mine/8i0l) | |
8K5R
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8k5r by Molmil](/molmil-images/mine/8k5r) | CDK9/cyclin T1 in complex with KB-0742 | 分子名称: | (1S,3S)-N3-(5-pentan-3-ylpyrazolo[1,5-a]pyrimidin-7-yl)cyclopentane-1,3-diamine, Cyclin-T1, Cyclin-dependent kinase 9 | 著者 | Zhou, M, Li, H, Gao, H, Trotter, B.W, Freeman, D. | 登録日 | 2023-07-24 | 公開日 | 2023-12-06 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (3.751 Å) | 主引用文献 | Discovery of KB-0742, a Potent, Selective, Orally Bioavailable Small Molecule Inhibitor of CDK9 for MYC-Dependent Cancers. J.Med.Chem., 66, 2023
|
|
8OR4
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8or4 by Molmil](/molmil-images/mine/8or4) | Partially dissociated CAND1-CUL1-RBX1-SKP1-SKP2-CKS1-CDK2 | 分子名称: | Cullin-1, Cullin-associated NEDD8-dissociated protein 1, Cyclin-dependent kinase 2, ... | 著者 | Shaaban, M, Clapperton, J.A, Ding, S, Maeots, M.E, Enchev, R.I. | 登録日 | 2023-04-13 | 公開日 | 2023-06-28 | 最終更新日 | 2024-07-24 | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | 主引用文献 | Structural and mechanistic insights into the CAND1-mediated SCF substrate receptor exchange. Mol.Cell, 83, 2023
|
|
8OR0
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8or0 by Molmil](/molmil-images/mine/8or0) | CAND1-CUL1-RBX1-SKP1-SKP2-CKS1-CDK2 | 分子名称: | Cullin-1, Cullin-associated NEDD8-dissociated protein 1, Cyclin-dependent kinase 2, ... | 著者 | Shaaban, M, Clapperton, J.A, Ding, S, Maeots, M.E, Enchev, R.I. | 登録日 | 2023-04-12 | 公開日 | 2023-06-28 | 最終更新日 | 2024-07-24 | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | 主引用文献 | Structural and mechanistic insights into the CAND1-mediated SCF substrate receptor exchange. Mol.Cell, 83, 2023
|
|
8P6Y
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8p6y by Molmil](/molmil-images/mine/8p6y) | Cryo-EM structure of CAK in complex with nucleotide analogue ATPgS | 分子名称: | CDK-activating kinase assembly factor MAT1, Cyclin-H, Cyclin-dependent kinase 7, ... | 著者 | Cushing, V.I, Koh, A.F, Feng, J, Jurgaityte, K, Bahl, A.K, Ali, S, Kotecha, A, Greber, B.J. | 登録日 | 2023-05-30 | 公開日 | 2023-08-30 | 最終更新日 | 2024-03-27 | 実験手法 | ELECTRON MICROSCOPY (1.9 Å) | 主引用文献 | High-resolution cryo-EM of the human CDK-activating kinase for structure-based drug design. Nat Commun, 15, 2024
|
|
8P6V
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8p6v by Molmil](/molmil-images/mine/8p6v) | Cryo-EM structure of CAK in complex with inhibitor ICEC0942 | 分子名称: | (3R,4R)-4-[[[7-[(phenylmethyl)amino]-3-propan-2-yl-pyrazolo[1,5-a]pyrimidin-5-yl]amino]methyl]piperidin-3-ol, CDK-activating kinase assembly factor MAT1, Cyclin-H, ... | 著者 | Cushing, V.I, Koh, A.F, Feng, J, Jurgaityte, K, Bahl, A.K, Ali, S, Kotecha, A, Greber, B.J. | 登録日 | 2023-05-30 | 公開日 | 2023-08-30 | 最終更新日 | 2024-03-27 | 実験手法 | ELECTRON MICROSCOPY (1.9 Å) | 主引用文献 | High-resolution cryo-EM of the human CDK-activating kinase for structure-based drug design. Nat Commun, 15, 2024
|
|
1E9H
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1e9h by Molmil](/molmil-images/mine/1e9h) | Thr 160 phosphorylated CDK2 - Human cyclin A3 complex with the inhibitor indirubin-5-sulphonate bound | 分子名称: | 2',3-DIOXO-1,1',2',3-TETRAHYDRO-2,3'-BIINDOLE-5'-SULFONIC ACID, CELL DIVISION PROTEIN KINASE 2, CYCLIN A3 | 著者 | Davies, T.G, Tunnah, P, Noble, M.E.M, Endicott, J.A. | 登録日 | 2000-10-16 | 公開日 | 2001-10-11 | 最終更新日 | 2024-05-01 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Inhibitor Binding to Active and Inactive Cdk2: The Crystal Structure of Cdk2-Cyclin A/Indirubin-5-Sulphonate Structure, 9, 2001
|
|
1F3M
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1f3m by Molmil](/molmil-images/mine/1f3m) | CRYSTAL STRUCTURE OF HUMAN SERINE/THREONINE KINASE PAK1 | 分子名称: | IODIDE ION, SERINE/THREONINE-PROTEIN KINASE PAK-ALPHA | 著者 | Lei, M, Lu, W, Meng, W, Parrini, M.-C, Eck, M.J, Mayer, B.J, Harrison, S.C. | 登録日 | 2000-06-05 | 公開日 | 2000-06-29 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Structure of PAK1 in an autoinhibited conformation reveals a multistage activation switch. Cell(Cambridge,Mass.), 102, 2000
|
|
1FIN
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1fin by Molmil](/molmil-images/mine/1fin) | |
1FQ1
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1fq1 by Molmil](/molmil-images/mine/1fq1) | CRYSTAL STRUCTURE OF KINASE ASSOCIATED PHOSPHATASE (KAP) IN COMPLEX WITH PHOSPHO-CDK2 | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, CELL DIVISION PROTEIN KINASE 2, CYCLIN-DEPENDENT KINASE INHIBITOR 3, ... | 著者 | Song, H, Hanlon, N, Brown, N.R, Noble, M.E.M, Johnson, L.N, Barford, D. | 登録日 | 2000-09-01 | 公開日 | 2001-05-09 | 最終更新日 | 2018-03-14 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | Phosphoprotein-protein interactions revealed by the crystal structure of kinase-associated phosphatase in complex with phosphoCDK2. Mol.Cell, 7, 2001
|
|
1CMK
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1cmk by Molmil](/molmil-images/mine/1cmk) | CRYSTAL STRUCTURES OF THE MYRISTYLATED CATALYTIC SUBUNIT OF CAMP-DEPENDENT PROTEIN KINASE REVEAL OPEN AND CLOSED CONFORMATIONS | 分子名称: | IODIDE ION, MYRISTIC ACID, cAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT, ... | 著者 | Zheng, J, Knighton, D.R, Xuong, N.-H, Taylor, S.S, Sowadski, J.M, Ten Eyck, L.F. | 登録日 | 1993-11-18 | 公開日 | 1994-05-31 | 最終更新日 | 2024-06-05 | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | 主引用文献 | Crystal structures of the myristylated catalytic subunit of cAMP-dependent protein kinase reveal open and closed conformations. Protein Sci., 2, 1993
|
|
1BUH
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1buh by Molmil](/molmil-images/mine/1buh) | |
1F5Q
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1f5q by Molmil](/molmil-images/mine/1f5q) | CRYSTAL STRUCTURE OF MURINE GAMMA HERPESVIRUS CYCLIN COMPLEXED TO HUMAN CYCLIN DEPENDENT KINASE 2 | 分子名称: | CHLORIDE ION, CYCLIN DEPENDENT KINASE 2, GAMMA HERPESVIRUS CYCLIN | 著者 | Card, G.L, Knowles, P, Laman, H, Jones, N, McDonald, N.Q. | 登録日 | 2000-06-15 | 公開日 | 2000-12-27 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Crystal structure of a gamma-herpesvirus cyclin-cdk complex. EMBO J., 19, 2000
|
|
1G3N
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1g3n by Molmil](/molmil-images/mine/1g3n) | |
1FVV
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1fvv by Molmil](/molmil-images/mine/1fvv) | THE STRUCTURE OF CDK2/CYCLIN A IN COMPLEX WITH AN OXINDOLE INHIBITOR | 分子名称: | 4-[(7-OXO-7H-THIAZOLO[5,4-E]INDOL-8-YLMETHYL)-AMINO]-N-PYRIDIN-2-YL-BENZENESULFONAMIDE, CYCLIN A, CYCLIN-DEPENDENT KINASE 2 | 著者 | Davis, S.T, Benson, B.G, Bramson, H.N, Chapman, D.E, Dickerson, S.H, Dold, K.M, Eberwein, D.J, Edelstein, M, Frye, S.V, Gampe Jr, R.T, Griffin, R.J, Harris, P.A, Hassell, A.M, Holmes, W.D, Hunter, R.N, Knick, V.B, Lackey, K, Lovejoy, B, Luzzio, M.J, Murray, D, Parker, P, Rocque, W.J, Shewchuk, L, Veal, J.M, Walker, D.H, Kuyper, L.K. | 登録日 | 2000-09-20 | 公開日 | 2001-01-17 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Prevention of chemotherapy-induced alopecia in rats by CDK inhibitors. Science, 291, 2001
|
|
6VP7
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6vp7 by Molmil](/molmil-images/mine/6vp7) | |
6W4O
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6w4o by Molmil](/molmil-images/mine/6w4o) | CaMKII alpha-30 Cryo-EM reconstruction | 分子名称: | Calcium/calmodulin-dependent protein kinase type II subunit alpha | 著者 | Chao, L.H, Stratton, M.M. | 登録日 | 2020-03-11 | 公開日 | 2020-07-15 | 最終更新日 | 2024-03-06 | 実験手法 | ELECTRON MICROSCOPY (4.8 Å) | 主引用文献 | Heterogeneity in human hippocampal CaMKII transcripts reveals allosteric hub-dependent regulation. Sci.Signal., 13, 2020
|
|
6W3K
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6w3k by Molmil](/molmil-images/mine/6w3k) | Structure of unphosphorylated human IRE1 bound to G-9807 | 分子名称: | 4-[5-[2,6-bis(fluoranyl)phenyl]-2~{H}-pyrazolo[3,4-b]pyridin-3-yl]-2-(4-oxidanylpiperidin-1-yl)-1~{H}-pyrimidin-6-one, Serine/threonine-protein kinase/endoribonuclease IRE1 | 著者 | Lammens, A, Wang, W, Ferri, E, Rudolph, J. | 登録日 | 2020-03-09 | 公開日 | 2020-12-09 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.08 Å) | 主引用文献 | Activation of the IRE1 RNase through remodeling of the kinase front pocket by ATP-competitive ligands. Nat Commun, 11, 2020
|
|
6W9E
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6w9e by Molmil](/molmil-images/mine/6w9e) | Crystal Structure of Human CDK9/cyclinT1 in complex with MC180295 | 分子名称: | (4-amino-2-{[(1R,2R,4S)-bicyclo[2.2.1]heptan-2-yl]amino}-1,3-thiazol-5-yl)(2-nitrophenyl)methanone, (4-amino-2-{[(1S,2S,4R)-bicyclo[2.2.1]heptan-2-yl]amino}-1,3-thiazol-5-yl)(2-nitrophenyl)methanone, Cyclin-T1, ... | 著者 | Zhang, P, Wu, J. | 登録日 | 2020-03-22 | 公開日 | 2021-09-01 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (3.1 Å) | 主引用文献 | Comparative Modeling of CDK9 Inhibitors to Explore Selectivity and Structure-Activity Relationships To Be Published
|
|
6XR4
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6xr4 by Molmil](/molmil-images/mine/6xr4) | |
6XBZ
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6xbz by Molmil](/molmil-images/mine/6xbz) | Structure of the human CDK-activating kinase | 分子名称: | CDK-activating kinase assembly factor MAT1, Cyclin-H, Cyclin-dependent kinase 7, ... | 著者 | Greber, B.J, Perez-Bertoldi, J.M, Lim, K, Iavarone, A.T, Toso, D.B, Nogales, E. | 登録日 | 2020-06-07 | 公開日 | 2020-09-09 | 最終更新日 | 2020-09-30 | 実験手法 | ELECTRON MICROSCOPY (2.8 Å) | 主引用文献 | The cryoelectron microscopy structure of the human CDK-activating kinase. Proc.Natl.Acad.Sci.USA, 117, 2020
|
|
6XDB
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6xdb by Molmil](/molmil-images/mine/6xdb) | Crystal structure of IRE1a in complex with G-6904 | 分子名称: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, 4-amino-N-(6-chloro-2-fluoro-3-{[(2-fluorophenyl)sulfonyl]amino}phenyl)-6-(1,3-dimethyl-1H-pyrazol-4-yl)quinazoline-8-carboxamide, Serine/threonine-protein kinase/endoribonuclease IRE1 | 著者 | Wallweber, H.A, Weiru, W. | 登録日 | 2020-06-10 | 公開日 | 2021-04-21 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.45 Å) | 主引用文献 | Identification of BRaf-Sparing Amino-Thienopyrimidines with Potent IRE1 alpha Inhibitory Activity. Acs Med.Chem.Lett., 11, 2020
|
|
6XD3
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6xd3 by Molmil](/molmil-images/mine/6xd3) | Structure of the human CAK in complex with THZ1 | 分子名称: | CDK-activating kinase assembly factor MAT1, Cyclin-H, Cyclin-dependent kinase 7, ... | 著者 | Greber, B.J, Perez-Bertoldi, J.M, Lim, K, Iavarone, A.T, Toso, D.B, Nogales, E. | 登録日 | 2020-06-09 | 公開日 | 2020-09-09 | 最終更新日 | 2020-09-30 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | The cryoelectron microscopy structure of the human CDK-activating kinase. Proc.Natl.Acad.Sci.USA, 117, 2020
|
|
6XDF
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6xdf by Molmil](/molmil-images/mine/6xdf) | Crystal structure of IRE1a in complex with G-4100 | 分子名称: | 4-amino-N-(6-chloro-2-fluoro-3-{[(pyrrolidin-1-yl)sulfonyl]amino}phenyl)quinazoline-8-carboxamide, SODIUM ION, Serine/threonine-protein kinase/endoribonuclease IRE1 | 著者 | Steinbacher, S, Wang, W. | 登録日 | 2020-06-10 | 公開日 | 2021-04-21 | 最終更新日 | 2024-03-06 | 実験手法 | X-RAY DIFFRACTION (2.54 Å) | 主引用文献 | Identification of BRaf-Sparing Amino-Thienopyrimidines with Potent IRE1 alpha Inhibitory Activity. Acs Med.Chem.Lett., 11, 2020
|
|