6W9E

Crystal Structure of Human CDK9/cyclinT1 in complex with MC180295

Summary for 6W9E

• Entry DOI: 10.2210/pdb6w9e/pdb
• Descriptor: Cyclin-dependent kinase 9, Cyclin-T1, (4-amino-2-{[(1S,2S,4R)-bicyclo[2.2.1]heptan-2-yl]amino}-1,3-thiazol-5-yl)(2-nitrophenyl)methanone, ... (6 entities in total)
• Functional Keywords: cdk9, cyclin t1, mc180295, complex, transcriptional regulator, transcription
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 2
• Total formula weight: 69736.17

Authors

Zhang, P.,Wu, J. (deposition date: 2020-03-22, release date: 2021-09-01, Last modification date: 2023-10-18)

• Primary citation: Kirubakaran, P.,Morton, G.,Zhang, P.,Zhang, H.,Abou-Gharbia, M.,Issa, J.,Wu, J.,Childers, W.,Karanicolas, J.; Comparative Modeling of CDK9 Inhibitors to Explore Selectivity and Structure-Activity Relationships; To Be Published,

Experimental method

X-RAY DIFFRACTION (3.1 Å)