6W9E
Crystal Structure of Human CDK9/cyclinT1 in complex with MC180295
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Cyclin-dependent kinase 9 | polymer | 330 | 38111.1 | 1 | UniProt (P50750) Pfam (PF00069) | Homo sapiens (Human) | C-2K,Cell division cycle 2-like protein kinase 4,Cell division protein kinase 9,Serine/threonine-protein kinase PITALRE,Tat-associated kinase complex catalytic subunit |
| 2 | B (B) | Cyclin-T1 | polymer | 259 | 30096.5 | 1 | UniProt (O60563) Pfam (PF00134) Pfam (PF21797) | Homo sapiens (Human) | Cyclin-T |
| 3 | C, D (A) | (4-amino-2-{[(1S,2S,4R)-bicyclo[2.2.1]heptan-2-yl]amino}-1,3-thiazol-5-yl)(2-nitrophenyl)methanone | non-polymer | 358.4 | 2 | Chemie (TO7) | |||
| 4 | E, F (A) | (4-amino-2-{[(1R,2R,4S)-bicyclo[2.2.1]heptan-2-yl]amino}-1,3-thiazol-5-yl)(2-nitrophenyl)methanone | non-polymer | 358.4 | 2 | Chemie (TOJ) | |||
| 5 | G (B) | PHOSPHATE ION | non-polymer | 95.0 | 1 | Chemie (PO4) | |||
| 6 | H, I (A, B) | water | water | 18.0 | 28 | Chemie (HOH) |
Sequence modifications
B: 1 - 259 (UniProt: O60563)
| PDB | External Database | Details |
|---|---|---|
| Arg 77 | Gln 77 | engineered mutation |
| Gly 96 | Glu 96 | engineered mutation |
| Leu 241 | Phe 241 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 68207.5 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 1528.6 | |
| All* | Total formula weight | 69736.2 |
