6W9E
Crystal Structure of Human CDK9/cyclinT1 in complex with MC180295
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004672 | molecular_function | protein kinase activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0006468 | biological_process | protein phosphorylation |
| B | 0006357 | biological_process | regulation of transcription by RNA polymerase II |
| B | 0016538 | molecular_function | cyclin-dependent protein serine/threonine kinase regulator activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 17 |
| Details | binding site for residue TO7 A 401 |
| Chain | Residue |
| A | PHE30 |
| A | ASP109 |
| A | LEU156 |
| A | ALA166 |
| A | ASP167 |
| A | TO7402 |
| A | TOJ403 |
| A | TOJ404 |
| A | HOH503 |
| A | VAL33 |
| A | VAL79 |
| A | PHE103 |
| A | ASP104 |
| A | PHE105 |
| A | CYS106 |
| A | GLU107 |
| A | HIS108 |
| site_id | AC2 |
| Number of Residues | 17 |
| Details | binding site for residue TO7 A 402 |
| Chain | Residue |
| A | PHE30 |
| A | VAL33 |
| A | LYS48 |
| A | VAL79 |
| A | PHE103 |
| A | ASP104 |
| A | PHE105 |
| A | CYS106 |
| A | GLU107 |
| A | HIS108 |
| A | ASP109 |
| A | LEU156 |
| A | ASP167 |
| A | TO7401 |
| A | TOJ403 |
| A | TOJ404 |
| A | HOH503 |
| site_id | AC3 |
| Number of Residues | 18 |
| Details | binding site for residue TOJ A 403 |
| Chain | Residue |
| A | ILE25 |
| A | PHE30 |
| A | VAL33 |
| A | ALA46 |
| A | LYS48 |
| A | PHE103 |
| A | ASP104 |
| A | PHE105 |
| A | CYS106 |
| A | GLU107 |
| A | ASN154 |
| A | LEU156 |
| A | ALA166 |
| A | ASP167 |
| A | TO7401 |
| A | TO7402 |
| A | TOJ404 |
| A | HOH503 |
| site_id | AC4 |
| Number of Residues | 16 |
| Details | binding site for residue TOJ A 404 |
| Chain | Residue |
| A | PHE30 |
| A | VAL33 |
| A | LYS48 |
| A | VAL79 |
| A | PHE103 |
| A | ASP104 |
| A | PHE105 |
| A | CYS106 |
| A | GLU107 |
| A | ASP109 |
| A | LEU156 |
| A | ASP167 |
| A | TO7401 |
| A | TO7402 |
| A | TOJ403 |
| A | HOH503 |
| site_id | AC5 |
| Number of Residues | 3 |
| Details | binding site for residue PO4 B 301 |
| Chain | Residue |
| B | LYS99 |
| B | LYS100 |
| B | HIS103 |
Functional Information from PROSITE/UniProt
| site_id | PS00107 |
| Number of Residues | 24 |
| Details | PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. IGQGTFGEVFkArhrktgqk..........VALK |
| Chain | Residue | Details |
| A | ILE25-LYS48 |
| site_id | PS00108 |
| Number of Residues | 13 |
| Details | PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. IlHrDMKaaNVLI |
| Chain | Residue | Details |
| A | ILE145-ILE157 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | Active site: {"description":"Proton acceptor","evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"},{"source":"PROSITE-ProRule","id":"PRU10027","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 8 |
| Details | Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"18566585","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"N6-acetyllysine; by EP300/CBP, PCAF/KAT2B and GCN5/KAT2A","evidences":[{"source":"PubMed","id":"17452463","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18250157","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"N6-acetyllysine; by PCAF/KAT2B and GCN5/KAT2A","evidences":[{"source":"PubMed","id":"18250157","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28426094","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"21533037","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphothreonine; by CaMK1D","evidences":[{"source":"PubMed","id":"15965233","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18483222","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18566585","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18829461","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20535204","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20851342","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21448926","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21779453","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21406692","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18691976","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"19369195","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"19369195","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
