PDB: 4955 件ウェブページステータス検索Chemie searchBIRD

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8FO2	Cryo-EM structure of Rab29-LRRK2 complex in the LRRK2 monomer state 分子名称: ADENOSINE-5'-TRIPHOSPHATE, GUANOSINE-5'-DIPHOSPHATE, Leucine-rich repeat serine/threonine-protein kinase 2, ... 著者 Zhu, H, Sun, J. 登録日 2022-12-29 公開日 2024-01-03 実験手法 ELECTRON MICROSCOPY (4.13 Å) 主引用文献 Rab29-dependent asymmetrical activation of leucine-rich repeat kinase 2. Science, 382, 2023
8FO8	Cryo-EM structure of Rab29-LRRK2 complex in the LRRK2 dimer state 分子名称: ADENOSINE-5'-TRIPHOSPHATE, GUANOSINE-5'-DIPHOSPHATE, Leucine-rich repeat serine/threonine-protein kinase 2, ... 著者 Zhu, H, Sun, J. 登録日 2022-12-29 公開日 2024-01-03 実験手法 ELECTRON MICROSCOPY (3.88 Å) 主引用文献 Rab29-dependent asymmetrical activation of leucine-rich repeat kinase 2. Science, 382, 2023
8FO9	Cryo-EM structure of Rab29-LRRK2 complex in the LRRK2 tetramer state 分子名称: ADENOSINE-5'-TRIPHOSPHATE, GUANOSINE-5'-DIPHOSPHATE, Leucine-rich repeat serine/threonine-protein kinase 2, ... 著者 Zhu, H, Sun, J. 登録日 2022-12-30 公開日 2024-01-03 実験手法 ELECTRON MICROSCOPY (3.48 Å) 主引用文献 Rab29-dependent asymmetrical activation of leucine-rich repeat kinase 2. Science, 382, 2023
8FO7	Cryo-EM structure of LRRK2 bound to type I inhibitor LRRK2-IN-1 分子名称: 2-[(2-methoxy-4-{[4-(4-methylpiperazin-1-yl)piperidin-1-yl]carbonyl}phenyl)amino]-5,11-dimethyl-5,11-dihydro-6H-pyrimido[4,5-b][1,4]benzodiazepin-6-one, GUANOSINE-5'-DIPHOSPHATE, Leucine-rich repeat serine/threonine-protein kinase 2 著者 Zhu, H, Sun, J. 登録日 2022-12-29 公開日 2024-01-17 最終更新日 2024-01-31 実験手法 ELECTRON MICROSCOPY (3.52 Å) 主引用文献 Pharmacology of LRRK2 with type I and II kinase inhibitors revealed by cryo-EM. Cell Discov, 10, 2024
8GXQ	PIC-Mediator in complex with +1 nucleosome (T40N) in MH-binding state 分子名称: CDK-activating kinase assembly factor MAT1, Cyclin-H, Cyclin-dependent kinase 7, ... 著者 Chen, X, Wang, X, Liu, W, Ren, Y, Qu, X, Li, J, Yin, X, Xu, Y. 登録日 2022-09-21 公開日 2022-11-02 実験手法 ELECTRON MICROSCOPY (5.04 Å) 主引用文献 Structures of +1 nucleosome-bound PIC-Mediator complex. Science, 378, 2022
8GXS	PIC-Mediator in complex with +1 nucleosome (T40N) in H-binding state 分子名称: CDK-activating kinase assembly factor MAT1, Cyclin-H, Cyclin-dependent kinase 7, ... 著者 Chen, X, Wang, X, Liu, W, Ren, Y, Qu, X, Li, J, Yin, X. 登録日 2022-09-21 公開日 2022-11-02 実験手法 ELECTRON MICROSCOPY (4.16 Å) 主引用文献 Structures of +1 nucleosome-bound PIC-Mediator complex. Science, 378, 2022
8GAE	Hsp90 provides platform for CRaf dephosphorylation by PP5 分子名称: ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Heat shock protein HSP 90-beta, ... 著者 Jaime-Garza, M, Nowotny, C.A, Coutandin, D, Wang, F, Tabios, M, Agard, D.A. 登録日 2023-02-22 公開日 2023-04-26 最終更新日 2023-05-03 実験手法 ELECTRON MICROSCOPY (3.3 Å) 主引用文献 Hsp90 provides a platform for kinase dephosphorylation by PP5. Nat Commun, 14, 2023
8GFT	Hsp90 provides platform for CRaf dephosphorylation by PP5 分子名称: ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Heat shock protein HSP 90-beta, ... 著者 Jaime-Garza, M, Nowotny, C.A, Coutandin, D, Wang, F, Tabios, M, Agard, D.A. 登録日 2023-03-08 公開日 2023-05-03 実験手法 ELECTRON MICROSCOPY (3.8 Å) 主引用文献 Hsp90 provides a platform for kinase dephosphorylation by PP5. Nat Commun, 14, 2023
8FP3	PKCeta kinase domain in complex with compound 11 分子名称: (3P)-3-{4-[(3R,5S)-3-amino-5-methylpiperidin-1-yl]-6-chloro-7H-pyrrolo[2,3-d]pyrimidin-5-yl}benzonitrile, Protein kinase C eta type 著者 Johnson, E. 登録日 2023-01-03 公開日 2023-04-05 最終更新日 2023-04-26 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Design and Synthesis of Functionally Active 5-Amino-6-Aryl Pyrrolopyrimidine Inhibitors of Hematopoietic Progenitor Kinase 1. J.Med.Chem., 66, 2023
8FP1	PKCeta kinase domain in complex with compound 2 分子名称: (3P)-3-[6-chloro-4-(9-methyl-1-oxa-4,9-diazaspiro[5.5]undecan-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl]benzonitrile, Protein kinase C eta type 著者 Johnson, E. 登録日 2023-01-03 公開日 2023-04-05 最終更新日 2023-04-26 実験手法 X-RAY DIFFRACTION (1.85 Å) 主引用文献 Design and Synthesis of Functionally Active 5-Amino-6-Aryl Pyrrolopyrimidine Inhibitors of Hematopoietic Progenitor Kinase 1. J.Med.Chem., 66, 2023
8G66	Structure with SJ3149 分子名称: (3S)-3-{5-[(1,2-benzoxazol-3-yl)amino]-1-oxo-1,3-dihydro-2H-isoindol-2-yl}piperidine-2,6-dione, Casein kinase I isoform alpha, DNA damage-binding protein 1, ... 著者 Miller, D.J, Young, S.M, Fischer, M. 登録日 2023-02-14 公開日 2023-12-13 実験手法 X-RAY DIFFRACTION (3.45 Å) 主引用文献 Structure of ternary complex with molecular glue targeting CK1A for degradation by the CRL4CRBN ubiquitin ligase To Be Published
5BNJ	CDK8/CYCC IN COMPLEX WITH 8-{3-Chloro-5-[4-(1-methyl-1H-pyrazol-4-yl)-phenyl]-pyridin- 4-yl}-2,8-diaza-spiro[4.5]decan-1-one 分子名称: 8-{3-chloro-5-[4-(1-methyl-1H-pyrazol-4-yl)phenyl]pyridin-4-yl}-2,8-diazaspiro[4.5]decan-1-one, Cyclin-C, Cyclin-dependent kinase 8, ... 著者 Musil, D, Blagg, J, Wienke, D. 登録日 2015-05-26 公開日 2015-10-14 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (2.64 Å) 主引用文献 A selective chemical probe for exploring the role of CDK8 and CDK19 in human disease. Nat.Chem.Biol., 11, 2015
7JHG	Cryo-EM structure of ATP-bound fully inactive AMPK in complex with Dorsomorphin (Compound C) and Fab-nanobody 分子名称: 5'-AMP-activated protein kinase catalytic subunit alpha-1, 5'-AMP-activated protein kinase subunit beta-2, 5'-AMP-activated protein kinase subunit gamma-1, ... 著者 Yan, Y, Murkherjee, S, Zhou, X.E, Xu, T.H, Xu, H.E, Kossiakoff, A.A, Melcher, K. 登録日 2020-07-20 公開日 2021-07-21 最終更新日 2021-12-15 実験手法 ELECTRON MICROSCOPY (3.47 Å) 主引用文献 Structure of an AMPK complex in an inactive, ATP-bound state. Science, 373, 2021
7JHH	Cryo-EM structure of ATP-bound fully inactive AMPK in complex with Fab and nanobody 分子名称: 5'-AMP-activated protein kinase catalytic subunit alpha-1, 5'-AMP-activated protein kinase subunit beta-2, 5'-AMP-activated protein kinase subunit gamma-1, ... 著者 Yan, Y, Murkherjee, S, Zhou, X.E, Xu, T.H, Xu, H.E, Kossiakoff, A.A, Melcher, K. 登録日 2020-07-20 公開日 2021-07-21 最終更新日 2021-12-15 実験手法 ELECTRON MICROSCOPY (3.92 Å) 主引用文献 Structure of an AMPK complex in an inactive, ATP-bound state. Science, 373, 2021
7JIJ	ATP-bound AMP-activated protein kinase 分子名称: 5'-AMP-activated protein kinase catalytic subunit alpha-1, 5'-AMP-activated protein kinase subunit beta-2, 5'-AMP-activated protein kinase subunit gamma-1, ... 著者 Yan, Y, Zhou, X.E, Powell, K, Xu, T, Brunzelle, J.S, Xu, H.X, Melcher, K. 登録日 2020-07-23 公開日 2021-07-28 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (5.5 Å) 主引用文献 Structure of an AMPK complex in an inactive, ATP-bound state. Science, 373, 2021
7JUT	Crystal Structure of KSR2:MEK1 in complex with ANP-PNP, and allosteric MEK inhibitor Selumetinib 分子名称: 5-[(4-bromo-2-chlorophenyl)amino]-4-fluoro-N-(2-hydroxyethoxy)-1-methyl-1H-benzimidazole-6-carboxamide, Dual specificity mitogen-activated protein kinase kinase 1, Kinase suppressor of Ras 2, ... 著者 Khan, Z.M, Dar, A.C. 登録日 2020-08-20 公開日 2020-09-30 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (3.09 Å) 主引用文献 Structural basis for the action of the drug trametinib at KSR-bound MEK. Nature, 588, 2020
7K7L	Structure of a hit for G Protein Coupled Receptor Kinase 2 (GRK2) Inhibitor for the Potential Treatment of Heart Failure 分子名称: 3-benzyl-6-(1H-pyrazol-4-yl)quinazolin-4(3H)-one, Beta-adrenergic receptor kinase 1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... 著者 Spurlino, J.C, Milligan, C. 登録日 2020-09-23 公開日 2020-10-28 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (2.539 Å) 主引用文献 Hit-to-lead optimization and discovery of a potent, and orally bioavailable G protein coupled receptor kinase 2 (GRK2) inhibitor. Bioorg.Med.Chem.Lett., 30, 2020
7JUV	Crystal Structure of KSR2:MEK1 in complex with AMP-PNP, and allosteric MEK inhibitor APS-9-95-1 分子名称: Dual specificity mitogen-activated protein kinase kinase 1, Kinase suppressor of Ras 2, MAGNESIUM ION, ... 著者 Khan, Z.M, Dar, A.C, Scopton, A.P. 登録日 2020-08-20 公開日 2020-09-30 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (3.36 Å) 主引用文献 Structural basis for the action of the drug trametinib at KSR-bound MEK. Nature, 588, 2020
7K7Z	Structure of a hit for G Protein Coupled Receptor Kinase 2 (GRK2) Inhibitor for the Potential Treatment of Heart Failure 分子名称: 3-benzyl-7-(1H-pyrazol-4-yl)quinazolin-4(3H)-one, Beta-adrenergic receptor kinase 1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... 著者 Spurlino, J.C, Milligan, C. 登録日 2020-09-24 公開日 2020-10-28 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (2.606087 Å) 主引用文献 Hit-to-lead optimization and discovery of a potent, and orally bioavailable G protein coupled receptor kinase 2 (GRK2) inhibitor. Bioorg.Med.Chem.Lett., 30, 2020
7JV0	Crystal Structure of KSR1:MEK1 in complex with AMP-PNP, and allosteric MEK inhibitor PD0325901 分子名称: Dual specificity mitogen-activated protein kinase kinase 1, Kinase suppressor of Ras 1, MAGNESIUM ION, ... 著者 Khan, Z.M, Dar, A.C. 登録日 2020-08-20 公開日 2020-09-30 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (3.63 Å) 主引用文献 Structural basis for the action of the drug trametinib at KSR-bound MEK. Nature, 588, 2020
7JUS	Crystal Structure of KSR2:MEK1 in complex with AMP-PNP, and allosteric MEK inhibitor Cobimetinib 分子名称: Cobimetinib, Dual specificity mitogen-activated protein kinase kinase 1, Kinase suppressor of Ras 2, ... 著者 Khan, Z.M, Dar, A.C. 登録日 2020-08-20 公開日 2020-09-30 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.99 Å) 主引用文献 Structural basis for the action of the drug trametinib at KSR-bound MEK. Nature, 588, 2020
7JUR	Crystal Structure of KSR2:MEK1 in complex with AMP-PNP, and allosteric MEK inhibitor Trametinib 分子名称: Dual specificity mitogen-activated protein kinase kinase 1, Kinase suppressor of Ras 2, MAGNESIUM ION, ... 著者 Khan, Z.M, Dar, A.C. 登録日 2020-08-20 公開日 2020-09-30 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.82 Å) 主引用文献 Structural basis for the action of the drug trametinib at KSR-bound MEK. Nature, 588, 2020
7JUX	Crystal Structure of KSR1:MEK1 in complex with AMP-PNP, and allosteric MEK inhibitor Trametinib 分子名称: Dual specificity mitogen-activated protein kinase kinase 1, Kinase suppressor of Ras 1, MAGNESIUM ION, ... 著者 Khan, Z.M, Dar, A.C. 登録日 2020-08-20 公開日 2020-09-30 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (3.34 Å) 主引用文献 Structural basis for the action of the drug trametinib at KSR-bound MEK. Nature, 588, 2020
7JUU	Crystal Structure of KSR2:MEK1 in complex with AMP-PNP, and allosteric MEK inhibitor PD0325901 分子名称: Dual specificity mitogen-activated protein kinase kinase 1, Kinase suppressor of Ras 2, MAGNESIUM ION, ... 著者 Khan, Z.M, Dar, A.C. 登録日 2020-08-20 公開日 2020-09-30 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (3.19 Å) 主引用文献 Structural basis for the action of the drug trametinib at KSR-bound MEK. Nature, 588, 2020
7JV7	Crystal Structure of the yeast RNA Pol II CTD kinase CTDK-1 complex 分子名称: CITRATE ANION, CTD kinase subunit alpha, CTD kinase subunit beta, ... 著者 Xie, Y, Ren, Y. 登録日 2020-08-20 公開日 2021-01-27 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (1.850553 Å) 主引用文献 Structure and activation mechanism of the yeast RNA Pol II CTD kinase CTDK-1 complex. Proc.Natl.Acad.Sci.USA, 118, 2021

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