8FO7
Cryo-EM structure of LRRK2 bound to type I inhibitor LRRK2-IN-1
Summary for 8FO7
Entry DOI | 10.2210/pdb8fo7/pdb |
EMDB information | 29340 |
Descriptor | Leucine-rich repeat serine/threonine-protein kinase 2, GUANOSINE-5'-DIPHOSPHATE, 2-[(2-methoxy-4-{[4-(4-methylpiperazin-1-yl)piperidin-1-yl]carbonyl}phenyl)amino]-5,11-dimethyl-5,11-dihydro-6H-pyrimido[4,5-b][1,4]benzodiazepin-6-one (3 entities in total) |
Functional Keywords | cryo-em, parkinson's disease, kinase, lrrk2, type i inhibitor, lrrk2-in-1, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 1 |
Total formula weight | 137887.45 |
Authors | |
Primary citation | Zhu, H.,Hixson, P.,Ma, W.,Sun, J. Pharmacology of LRRK2 with type I and II kinase inhibitors revealed by cryo-EM. Cell Discov, 10:10-10, 2024 Cited by PubMed: 38263358DOI: 10.1038/s41421-023-00639-8 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (3.52 Å) |
Structure validation
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