8FO7
Cryo-EM structure of LRRK2 bound to type I inhibitor LRRK2-IN-1
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (C) | Leucine-rich repeat serine/threonine-protein kinase 2 | polymer | 1201 | 136873.6 | 1 | UniProt (Q5S007) Pfam (PF08477) Pfam (PF16095) Pfam (PF25497) Pfam (PF00069) Pfam (PF23748) | Homo sapiens (human) | Dardarin |
| 2 | B (C) | GUANOSINE-5'-DIPHOSPHATE | non-polymer | 443.2 | 1 | Chemie (GDP) PubChem (136073927) PubChem (135398619) PubChem (135402030) PubChem (135431654) PubChem (135566337) PubChem (135760556) PubChem (136026707) PubChem (136053418) PubChem (136663964) PubChem (136664748) PubChem (136759848) PubChem (136759849) PubChem (136759850) PubChem (136836636) PubChem (136847074) PubChem (172898537) | |||
| 3 | C (C) | 2-[(2-methoxy-4-{[4-(4-methylpiperazin-1-yl)piperidin-1-yl]carbonyl}phenyl)amino]-5,11-dimethyl-5,11-dihydro-6H-pyrimido[4,5-b][1,4]benzodiazepin-6-one | non-polymer | 570.7 | 1 | Chemie (4K4) PubChem (46843906) |
Sequence modifications
C: 1327 - 2527 (UniProt: Q5S007)
| PDB | External Database | Details |
|---|---|---|
| Thr 1647 | Ser 1647 | conflict |
| Arg 1732 | Met 1732 | conflict |
| Thr 2397 | Met 2397 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 136873.6 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 1013.9 | |
| All* | Total formula weight | 137887.4 |
