8FO7
Cryo-EM structure of LRRK2 bound to type I inhibitor LRRK2-IN-1
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (C) | Leucine-rich repeat serine/threonine-protein kinase 2 | polymer | 1201 | 136873.6 | 1 | UniProt (Q5S007) Pfam (PF08477) Pfam (PF16095) Pfam (PF00069) | Homo sapiens (human) | Dardarin |
| 2 | B (C) | GUANOSINE-5'-DIPHOSPHATE | non-polymer | 443.2 | 1 | Chemie (GDP) | |||
| 3 | C (C) | 2-[(2-methoxy-4-{[4-(4-methylpiperazin-1-yl)piperidin-1-yl]carbonyl}phenyl)amino]-5,11-dimethyl-5,11-dihydro-6H-pyrimido[4,5-b][1,4]benzodiazepin-6-one | non-polymer | 570.7 | 1 | Chemie (4K4) |
Sequence modifications
C: 1327 - 2527 (UniProt: Q5S007)
| PDB | External Database | Details |
|---|---|---|
| Thr 1647 | Ser 1647 | conflict |
| Arg 1732 | Met 1732 | conflict |
| Thr 2397 | Met 2397 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 136873.6 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 1013.9 | |
| All* | Total formula weight | 137887.4 |
