8FO2

Cryo-EM structure of Rab29-LRRK2 complex in the LRRK2 monomer state

Summary for 8FO2

• Entry DOI: 10.2210/pdb8fo2/pdb
• EMDB information: 29339
• Descriptor: Ras-related protein Rab-7L1, Leucine-rich repeat serine/threonine-protein kinase 2, MAGNESIUM ION, ... (6 entities in total)
• Functional Keywords: cryo-em, parkinson's disease, kinase, lrrk2, rab gtpases, activation, hydrolase
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 2
• Total formula weight: 308163.61

Authors

Zhu, H.,Sun, J. (deposition date: 2022-12-29, release date: 2024-01-03)

• Primary citation: Zhu, H.,Tonelli, F.,Turk, M.,Prescott, A.,Alessi, D.R.,Sun, J.; Rab29-dependent asymmetrical activation of leucine-rich repeat kinase 2.; Science, 382:1404-1411, 2023; PubMed: 38127736; DOI: 10.1126/science.adi9926

Experimental method

ELECTRON MICROSCOPY (4.13 Å)