8FO2
Cryo-EM structure of Rab29-LRRK2 complex in the LRRK2 monomer state
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (B) | Ras-related protein Rab-7L1 | polymer | 177 | 20239.1 | 1 | UniProt (O14966) Pfam (PF00071) | Homo sapiens (human) | Rab-7-like protein 1,Ras-related protein Rab-29 |
| 2 | B (E) | Leucine-rich repeat serine/threonine-protein kinase 2 | polymer | 2527 | 286427.7 | 1 | UniProt (Q5S007) Pfam (PF23744) Pfam (PF23745) Pfam (PF13855) Pfam (PF08477) Pfam (PF16095) Pfam (PF25497) Pfam (PF00069) Pfam (PF23748) | Homo sapiens (human) | Dardarin |
| 3 | C (B) | MAGNESIUM ION | non-polymer | 24.3 | 1 | Chemie (MG) PubChem (888) | |||
| 4 | D (B) | PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER | non-polymer | 522.2 | 1 | Chemie (GNP) | |||
| 5 | E (E) | GUANOSINE-5'-DIPHOSPHATE | non-polymer | 443.2 | 1 | Chemie (GDP) PubChem (136073927) PubChem (135398619) PubChem (135402030) PubChem (135431654) PubChem (135566337) PubChem (135760556) PubChem (136026707) PubChem (136053418) PubChem (136663964) PubChem (136664748) PubChem (136759848) PubChem (136759849) PubChem (136759850) PubChem (136836636) PubChem (136847074) PubChem (172898537) | |||
| 6 | F (E) | ADENOSINE-5'-TRIPHOSPHATE | non-polymer | 507.2 | 1 | Chemie (ATP) |
Sequence modifications
B: 1 - 177 (UniProt: O14966)
E: 1 - 2527 (UniProt: Q5S007)
| PDB | External Database | Details |
|---|---|---|
| Leu 67 | Gln 67 | conflict |
| Ala 71 | Thr 71 | conflict |
| Ala 72 | Ser 72 | conflict |
| PDB | External Database | Details |
|---|---|---|
| His 50 | Arg 50 | conflict |
| Thr 1647 | Ser 1647 | conflict |
| Thr 2397 | Met 2397 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 306666.7 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 1496.9 | |
| All* | Total formula weight | 308163.6 |
