7VDH
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![BU of 7vdh by Molmil](/molmil-images/mine/7vdh) | Cryo-EM structure of pseudoallergen receptor MRGPRX2 complex with C48/80, state2 | 分子名称: | 2-[4-methoxy-3-[[2-methoxy-3-[[2-methoxy-5-[2-(methylamino)ethyl]phenyl]methyl]-5-[2-(methylamino)ethyl]phenyl]methyl]phenyl]-~{N}-methyl-ethanamine, CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | 著者 | Li, Y, Yang, F. | 登録日 | 2021-09-07 | 公開日 | 2021-12-01 | 最終更新日 | 2022-07-20 | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | 主引用文献 | Structure, function and pharmacology of human itch receptor complexes. Nature, 600, 2021
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6XU1
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![BU of 6xu1 by Molmil](/molmil-images/mine/6xu1) | Crystal structure of tetrameric human H215A-SAMHD1 (residues 109-626) with GTP, dAMPNPP and Mg | 分子名称: | 2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]adenosine, Deoxynucleoside triphosphate triphosphohydrolase SAMHD1, FE (III) ION, ... | 著者 | Morris, E.R, Kunzelmann, S, Caswell, S.J, Arnold, L.H, Purkiss, A.G, Kelly, G, Taylor, I.A. | 登録日 | 2020-01-17 | 公開日 | 2020-06-24 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Crystal structures of SAMHD1 inhibitor complexes reveal the mechanism of water-mediated dNTP hydrolysis. Nat Commun, 11, 2020
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6E62
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![BU of 6e62 by Molmil](/molmil-images/mine/6e62) | Crystal structure of malaria transmission-blocking antigen Pfs48/45 6C in complex with antibody 85RF45.1 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 85RF45.1 Fab heavy chain, 85RF45.1 Fab light chain, ... | 著者 | Kundu, P, Semesi, A, Julien, J.P. | 登録日 | 2018-07-23 | 公開日 | 2018-11-28 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Structural delineation of potent transmission-blocking epitope I on malaria antigen Pfs48/45. Nat Commun, 9, 2018
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7VV0
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7VV6
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![BU of 7vv6 by Molmil](/molmil-images/mine/7vv6) | Cryo-EM structure of pseudoallergen receptor MRGPRX2 complex with C48/80 (local) | 分子名称: | 2-[4-methoxy-3-[[2-methoxy-3-[[2-methoxy-5-[2-(methylamino)ethyl]phenyl]methyl]-5-[2-(methylamino)ethyl]phenyl]methyl]phenyl]-~{N}-methyl-ethanamine, CHOLESTEROL, Mas-related G-protein coupled receptor member X2 | 著者 | Li, Y, Yang, F. | 登録日 | 2021-11-04 | 公開日 | 2021-12-01 | 最終更新日 | 2022-07-20 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | Structure, function and pharmacology of human itch receptor complexes. Nature, 600, 2021
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7VUY
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7VV3
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6X71
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6XY3
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6XXF
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6XXX
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6UK2
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6UJO
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7JUP
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![BU of 7jup by Molmil](/molmil-images/mine/7jup) | Structure of human TRPA1 in complex with antagonist compound 21 | 分子名称: | 1-({3-[(3R,5R)-5-(4-fluorophenyl)oxolan-3-yl]-1,2,4-oxadiazol-5-yl}methyl)-7-methyl-1,7-dihydro-6H-purin-6-one, Transient receptor potential cation channel subfamily A member 1 | 著者 | Rohou, A, Rouge, L. | 登録日 | 2020-08-20 | 公開日 | 2021-03-31 | 最終更新日 | 2024-03-06 | 実験手法 | ELECTRON MICROSCOPY (3.05 Å) | 主引用文献 | Tetrahydrofuran-Based Transient Receptor Potential Ankyrin 1 (TRPA1) Antagonists: Ligand-Based Discovery, Activity in a Rodent Asthma Model, and Mechanism-of-Action via Cryogenic Electron Microscopy. J.Med.Chem., 64, 2021
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6L1T
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![BU of 6l1t by Molmil](/molmil-images/mine/6l1t) | Cryo-EM structure of phosphorylated Tyr39 a-synuclein amyloid fibril | 分子名称: | Alpha-synuclein | 著者 | Liu, C, Li, Y.M, Zhao, K, Lim, Y.J, Liu, Z.Y. | 登録日 | 2019-09-30 | 公開日 | 2020-08-12 | 最終更新日 | 2020-09-02 | 実験手法 | ELECTRON MICROSCOPY (3.22 Å) | 主引用文献 | Parkinson's disease-related phosphorylation at Tyr39 rearranges alpha-synuclein amyloid fibril structure revealed by cryo-EM. Proc.Natl.Acad.Sci.USA, 117, 2020
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6E65
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6E6T
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![BU of 6e6t by Molmil](/molmil-images/mine/6e6t) | Dieckmann cyclase, NcmC, bound to cerulenin | 分子名称: | (4S,5R)-4,5-dihydroxy-5-[(3E,6E)-octa-3,6-dien-1-yl]pyrrolidin-2-one, NcmC, SULFATE ION | 著者 | Cogan, D.P, Nair, S.K. | 登録日 | 2018-07-25 | 公開日 | 2019-07-31 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | Structural Basis for Enzymatic Off-Loading of Hybrid Polyketides by Dieckmann Condensation. Acs Chem.Biol., 2020
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6U60
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![BU of 6u60 by Molmil](/molmil-images/mine/6u60) | Crystal structure of prephenate dehydrogenase tyrA from Bacillus anthracis in complex with NAD and L-tyrosine | 分子名称: | NICOTINAMIDE-ADENINE-DINUCLEOTIDE, PHOSPHATE ION, Prephenate dehydrogenase, ... | 著者 | Shabalin, I.G, Hou, J, Kutner, J, Grimshaw, S, Christendat, D, Anderson, W.F, Minor, W, Center for Structural Genomics of Infectious Diseases (CSGID) | 登録日 | 2019-08-28 | 公開日 | 2019-09-11 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Structural and biochemical analysis of Bacillus anthracis prephenate dehydrogenase reveals an unusual mode of inhibition by tyrosine via the ACT domain. Febs J., 287, 2020
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6E6U
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7KBE
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7KBD
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6U8P
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![BU of 6u8p by Molmil](/molmil-images/mine/6u8p) | Crystal structure of DNMT3B-DNMT3L in complex with CpGpA DNA | 分子名称: | CpGpA DNA (25-MER), DNA (cytosine-5)-methyltransferase 3-like, DNA (cytosine-5)-methyltransferase 3B, ... | 著者 | Gao, L, Song, J. | 登録日 | 2019-09-05 | 公開日 | 2020-06-10 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (3.05 Å) | 主引用文献 | Comprehensive structure-function characterization of DNMT3B and DNMT3A reveals distinctive de novo DNA methylation mechanisms. Nat Commun, 11, 2020
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7KBF
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6E64
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6UK4
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![BU of 6uk4 by Molmil](/molmil-images/mine/6uk4) | |