7SKT
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5IB2
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![BU of 5ib2 by Molmil](/molmil-images/mine/5ib2) | Crystal structure of HLA-B*27:05 complexed with the self-peptide pVIPR | 分子名称: | Beta-2-microglobulin, GLYCEROL, HLA class I histocompatibility antigen, ... | 著者 | Janke, R, Ballaschk, M, Schmieder, P, Uchanska-Ziegler, B, Ziegler, A, Loll, B. | 登録日 | 2016-02-22 | 公開日 | 2017-02-01 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (1.44 Å) | 主引用文献 | Metal-triggered conformational reorientation of a self-peptide bound to a disease-associated HLA-B*27 subtype. J.Biol.Chem., 2019
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4XG0
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![BU of 4xg0 by Molmil](/molmil-images/mine/4xg0) | Crystal structure of a domain of unknown function (DUF1537) from Bordetella bronchiseptica (BB3215), Target EFI-511620, with bound citrate, domain swapped dimer, space group C2221 | 分子名称: | CHLORIDE ION, CITRIC ACID, SULFATE ION, ... | 著者 | Vetting, M.W, Al Obaidi, N.F, Toro, R, Morisco, L.L, Benach, J, Wasserman, S.R, Attonito, J.D, Scott Glenn, A, Chamala, S, Chowdhury, S, Lafleur, J, Love, J, Seidel, R.D, Whalen, K.L, Gerlt, J.A, Almo, S.C, Enzyme Function Initiative (EFI) | 登録日 | 2014-12-30 | 公開日 | 2015-03-11 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Assignment of function to a domain of unknown function: DUF1537 is a new kinase family in catabolic pathways for acid sugars. Proc.Natl.Acad.Sci.USA, 113, 2016
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5IB5
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![BU of 5ib5 by Molmil](/molmil-images/mine/5ib5) | Crystal structure of HLA-B*27:09 complexed with the self-peptide pVIPR and Copper | 分子名称: | Beta-2-microglobulin, CHLORIDE ION, COPPER (II) ION, ... | 著者 | Janke, R, Ballaschk, M, Schmieder, P, Uchanska-Ziegler, B, Ziegler, A, Loll, B. | 登録日 | 2016-02-22 | 公開日 | 2017-02-01 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (2.49 Å) | 主引用文献 | Metal-triggered conformational reorientation of a self-peptide bound to a disease-associated HLA-B*27 subtype. J.Biol.Chem., 2019
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7SH4
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![BU of 7sh4 by Molmil](/molmil-images/mine/7sh4) | CD1a-phosphatidylglycerol binary structure | 分子名称: | (21R,24R,27S)-24,27,28-trihydroxy-18,24-dioxo-19,23,25-trioxa-24lambda~5~-phosphaoctacosan-21-yl (9Z)-octadec-9-enoate, 1,2-ETHANEDIOL, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, ... | 著者 | Wegrecki, M, Rossjohn, J. | 登録日 | 2021-10-07 | 公開日 | 2022-10-05 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Staphylococcal phosphatidylglycerol antigens activate human T cells via CD1a. Nat.Immunol., 24, 2023
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8CPE
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6A9F
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![BU of 6a9f by Molmil](/molmil-images/mine/6a9f) | Crystal structure of a cyclase from Fischerella sp. TAU in complex with 4-(1H-Indol-3-yl)butan-2-one | 分子名称: | 4-(1~{H}-indol-3-yl)butan-2-one, CALCIUM ION, GLYCEROL, ... | 著者 | Hu, X.Y, Liu, W.D, Chen, C.C, Guo, R.T. | 登録日 | 2018-07-13 | 公開日 | 2018-12-19 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | The Crystal Structure of a Class of Cyclases that Catalyze the Cope Rearrangement Angew. Chem. Int. Ed. Engl., 57, 2018
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8CB1
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![BU of 8cb1 by Molmil](/molmil-images/mine/8cb1) | Crystal structure of human lysosomal acid-alpha-glucosidase, GAA, in complex with N-PNT-DNM 15 | 分子名称: | (2R,3R,4R,5S)-2-(hydroxymethyl)-1-[5-(phenanthren-9-ylmethoxy)pentyl]piperidine-3,4,5-triol, 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Sulzenbacher, G, Roig-Zamboni, V, Overkleeft, H, Artola, M. | 登録日 | 2023-01-25 | 公開日 | 2023-09-13 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | 主引用文献 | Fluorescence polarisation activity-based protein profiling for the identification of deoxynojirimycin-type inhibitors selective for lysosomal retaining alpha- and beta-glucosidases. Chem Sci, 14, 2023
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8CB6
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![BU of 8cb6 by Molmil](/molmil-images/mine/8cb6) | Crystal structure of human lysosomal acid-alpha-glucosidase, GAA, in covalent complex with TAMRA tagged 1,6-Epi-cylcophellitol aziridine activity based probe | 分子名称: | (1S,2R,3R,4R,5R)-5-[8-[4-(4-azanylbutyl)-1,2,3-triazol-1-yl]octylamino]-4-(hydroxymethyl)cyclohexane-1,2,3-triol, 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Sulzenbacher, G, Roig-Zamboni, V, Overkleeft, H, Artola, M. | 登録日 | 2023-01-25 | 公開日 | 2023-09-13 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Fluorescence polarisation activity-based protein profiling for the identification of deoxynojirimycin-type inhibitors selective for lysosomal retaining alpha- and beta-glucosidases. Chem Sci, 14, 2023
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8CML
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6A99
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![BU of 6a99 by Molmil](/molmil-images/mine/6a99) | Crystal structure of a Stig cyclases Fisc from Fischerella sp. TAU in complex with (3Z)-3-(1-methyl-2-pyrrolidinylidene)-3H-indole | 分子名称: | (3~{Z})-3-(1-methylpyrrolidin-2-ylidene)indole, CALCIUM ION, MAGNESIUM ION, ... | 著者 | Hu, X.Y, Liu, W.D, Chen, C.C, Guo, R.T. | 登録日 | 2018-07-12 | 公開日 | 2018-12-19 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.29 Å) | 主引用文献 | The Crystal Structure of a Class of Cyclases that Catalyze the Cope Rearrangement Angew. Chem. Int. Ed. Engl., 57, 2018
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5ITP
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7SEH
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![BU of 7seh by Molmil](/molmil-images/mine/7seh) | Glucose-6-phosphate 1-dehydrogenase (K403QdLtL) | 分子名称: | Glucose-6-phosphate 1-dehydrogenase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | 著者 | Mathews, I.I, Garcia, A.A, Wakatsuki, S, Mochly-Rosen, D. | 登録日 | 2021-09-30 | 公開日 | 2022-08-17 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | 主引用文献 | Stabilization of glucose-6-phosphate dehydrogenase oligomers enhances catalytic activity and stability of clinical variants. J.Biol.Chem., 298, 2022
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4XWY
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![BU of 4xwy by Molmil](/molmil-images/mine/4xwy) | Crystal structure of human sepiapterin reductase in complex with an N-acetylserotinin analogue | 分子名称: | N-[2-(5-hydroxy-2-methyl-1H-indol-3-yl)ethyl]-2-methoxyacetamide, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, SULFATE ION, ... | 著者 | Johnsson, K, Hovius, R, Gorszka, K.I, Pojer, F. | 登録日 | 2015-01-29 | 公開日 | 2015-07-01 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (2.35 Å) | 主引用文献 | Reduction of Neuropathic and Inflammatory Pain through Inhibition of the Tetrahydrobiopterin Pathway. Neuron, 86, 2015
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6ADU
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![BU of 6adu by Molmil](/molmil-images/mine/6adu) | Crystal structure of an enzyme in complex with ligand C | 分子名称: | (3~{Z})-3-(1-methylpyrrolidin-2-ylidene)indole, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CALCIUM ION, ... | 著者 | Tan, X.K, Liu, W.D, Chen, C.C, Guo, R.T. | 登録日 | 2018-08-02 | 公開日 | 2019-08-21 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (1.96 Å) | 主引用文献 | The Crystal Structure of a Class of Cyclases that Catalyze the Cope Rearrangement. Angew.Chem.Int.Ed.Engl., 57, 2018
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5J1A
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![BU of 5j1a by Molmil](/molmil-images/mine/5j1a) | Antigen presenting molecule | 分子名称: | 3-[(8Z,11Z)-pentadeca-8,11-dien-1-yl]benzene-1,2-diol, Beta-2-microglobulin, T-cell surface glycoprotein CD1a | 著者 | Yongqing, T, Rossjohn, J, Le Nours, J, Marquez, E, Winau, F. | 登録日 | 2016-03-29 | 公開日 | 2016-08-03 | 最終更新日 | 2018-04-04 | 実験手法 | X-RAY DIFFRACTION (1.86 Å) | 主引用文献 | CD1a on Langerhans cells controls inflammatory skin disease. Nat. Immunol., 17, 2016
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7SIH
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![BU of 7sih by Molmil](/molmil-images/mine/7sih) | Crystal Structure of HLA B*3503 in complex with NPDIVIYQY, an 9-mer epitope from HIV-I | 分子名称: | Beta-2-microglobulin, GLYCEROL, MHC class I antigen, ... | 著者 | Gras, S, Lobos, C.A, Chatzileontiadou, D.S.M. | 登録日 | 2021-10-14 | 公開日 | 2022-11-23 | 最終更新日 | 2024-06-05 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Molecular insights into the HLA-B35 molecules' classification associated with HIV control. Immunol.Cell.Biol., 102, 2024
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7SIG
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![BU of 7sig by Molmil](/molmil-images/mine/7sig) | Crystal Structure of HLA B*3501 in complex with NPDIVIYQY, an 9-mer epitope from HIV-I | 分子名称: | Beta-2-microglobulin, CITRATE ANION, MHC class I antigen, ... | 著者 | Gras, S, Lobos, C.A, Chatzileontiadou, D.S.M. | 登録日 | 2021-10-14 | 公開日 | 2022-11-23 | 最終更新日 | 2024-06-05 | 実験手法 | X-RAY DIFFRACTION (1.741 Å) | 主引用文献 | Molecular insights into the HLA-B35 molecules' classification associated with HIV control. Immunol.Cell.Biol., 102, 2024
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7SEI
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![BU of 7sei by Molmil](/molmil-images/mine/7sei) | Glucose-6-phosphate 1-dehydrogenase (K403Q) | 分子名称: | Glucose-6-phosphate 1-dehydrogenase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | 著者 | Mathews, I.I, Garcia, A.A, Wakatsuki, S, Mochly-Rosen, D. | 登録日 | 2021-09-30 | 公開日 | 2022-08-17 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (3.65 Å) | 主引用文献 | Stabilization of glucose-6-phosphate dehydrogenase oligomers enhances catalytic activity and stability of clinical variants. J.Biol.Chem., 298, 2022
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5J9A
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![BU of 5j9a by Molmil](/molmil-images/mine/5j9a) | Ambient temperature transition state structure of arginine kinase - crystal 11/Form II | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, ARGININE, Arginine kinase, ... | 著者 | Godsey, M, Davulcu, O, Nix, J, Skalicky, J.J, Bruschweiler, R, Chapman, M.S. | 登録日 | 2016-04-08 | 公開日 | 2016-08-17 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (1.997 Å) | 主引用文献 | The Sampling of Conformational Dynamics in Ambient-Temperature Crystal Structures of Arginine Kinase. Structure, 24, 2016
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8BZL
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![BU of 8bzl by Molmil](/molmil-images/mine/8bzl) | Human 20S Proteasome in complex with peptide activator peptide BLM42 | 分子名称: | ARG-SER-TYR-TYR-SER, CHLORIDE ION, MAGNESIUM ION, ... | 著者 | Henneberg, F, Chari, A, Jankowska, E, Witkowska, J. | 登録日 | 2022-12-15 | 公開日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (2.14 Å) | 主引用文献 | Peptidic, Blm10-based activators of human 20S proteasome in vitro and in cellulo enhance degradation of proteins connected with neurodegeneration. To Be Published
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6B0W
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![BU of 6b0w by Molmil](/molmil-images/mine/6b0w) | Crystal structure of the anti-circumsporozoite protein 1710 antibody | 分子名称: | 1710 antibody, heavy chain, light chain, ... | 著者 | Scally, S.W, Murugan, R, Bosch, A, Triller, G, Wardemann, H, Julien, J.P. | 登録日 | 2017-09-15 | 公開日 | 2017-11-08 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Rare PfCSP C-terminal antibodies induced by live sporozoite vaccination are ineffective against malaria infection. J. Exp. Med., 215, 2018
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4XRZ
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![BU of 4xrz by Molmil](/molmil-images/mine/4xrz) | Human Cytochrome P450 2D6 BACE1 Inhibitor 6 Complex | 分子名称: | (4aR,6R,8aS)-8a-(2,4-difluorophenyl)-6-(1H-pyrazol-4-yl)-4,4a,5,6,8,8a-hexahydropyrano[3,4-d][1,3]thiazin-2-amine, Cytochrome P450 2D6, GLYCEROL, ... | 著者 | Johnson, E.F, Fan, Y. | 登録日 | 2015-01-21 | 公開日 | 2015-05-20 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Utilizing Structures of CYP2D6 and BACE1 Complexes To Reduce Risk of Drug-Drug Interactions with a Novel Series of Centrally Efficacious BACE1 Inhibitors. J.Med.Chem., 58, 2015
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5ITO
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8CNZ
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![BU of 8cnz by Molmil](/molmil-images/mine/8cnz) | mmLarE-[4Fe-4S] phased by Fe-SAD | 分子名称: | CHLORIDE ION, IODIDE ION, IRON/SULFUR CLUSTER, ... | 著者 | Pecqueur, L, Zecchin, P, Golinelli-Pimpaneau, B. | 登録日 | 2023-02-24 | 公開日 | 2024-01-31 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (3.6 Å) | 主引用文献 | Structure-based insights into the mechanism of [4Fe-4S]-dependent sulfur insertase LarE. Protein Sci., 33, 2024
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