8CB1

Crystal structure of human lysosomal acid-alpha-glucosidase, GAA, in complex with N-PNT-DNM 15

Summary for 8CB1

Entry DOI	10.2210/pdb8cb1/pdb
Descriptor	Lysosomal alpha-glucosidase (76 kDa), 1,2-ETHANEDIOL, (2R,3R,4R,5S)-2-(hydroxymethyl)-1-[5-(phenanthren-9-ylmethoxy)pentyl]piperidine-3,4,5-triol, ... (13 entities in total)
Functional Keywords	gaa, pompe disease, pharmacological chaperone, hydrolase
Biological source	Homo sapiens (human) More
Total number of polymer chains	2
Total formula weight	102042.72
Authors	Sulzenbacher, G.,Roig-Zamboni, V.,Overkleeft, H.,Artola, M. (deposition date: 2023-01-25, release date: 2023-09-13, Last modification date: 2023-11-15)
Primary citation	van der Gracht, D.,Rowland, R.J.,Roig-Zamboni, V.,Ferraz, M.J.,Louwerse, M.,Geurink, P.P.,Aerts, J.M.F.G.,Sulzenbacher, G.,Davies, G.J.,Overkleeft, H.S.,Artola, M. Fluorescence polarisation activity-based protein profiling for the identification of deoxynojirimycin-type inhibitors selective for lysosomal retaining alpha- and beta-glucosidases. Chem Sci, 14:9136-9144, 2023 Cited by PubMed: 37655021 DOI: 10.1039/d3sc01021j PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.75 Å)

Structure validation