8CB1
Crystal structure of human lysosomal acid-alpha-glucosidase, GAA, in complex with N-PNT-DNM 15
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (G) | Lysosomal alpha-glucosidase (76 kDa) | polymer | 123 | 14095.0 | 1 | UniProt (P10253) Pfam (PF00088) | Homo sapiens (human) | Acid maltase,Aglucosidase alfa |
| 2 | B (A) | Lysosomal alpha-glucosidase (70 kDa) | polymer | 749 | 82901.6 | 1 | UniProt (P10253) Pfam (PF13802) Pfam (PF01055) Pfam (PF21365) | Homo sapiens (human) | |
| 3 | C (B) | beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 732.7 | 1 | In PDB GlyTouCan (G32152BH) | |||
| 4 | D, E (C, D) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 2 | In PDB GlyTouCan (G42666HT) | |||
| 5 | F (E) | beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 586.5 | 1 | In PDB GlyTouCan (G15407YE) | |||
| 6 | G (F) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 570.5 | 1 | In PDB GlyTouCan (G21290RB) | |||
| 7 | H, I, S, T, U... (G, A) | CHLORIDE ION | non-polymer | 35.5 | 10 | Chemie (CL) | |||
| 8 | AA, BA, CA, J (A, G) | GLYCEROL | non-polymer | 92.1 | 4 | Chemie (GOL) | |||
| 9 | DA, EA, K (A, G) | TRIETHYLENE GLYCOL | non-polymer | 150.2 | 3 | Chemie (PGE) | |||
| 10 | FA, GA, HA, L, M (A, G) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 5 | Chemie (EDO) | |||
| 11 | N (A) | (2R,3R,4R,5S)-2-(hydroxymethyl)-1-[5-(phenanthren-9-ylmethoxy)pentyl]piperidine-3,4,5-triol | non-polymer | 439.5 | 1 | Chemie (U4X) | |||
| 12 | O, P, Q, R (A) | SULFATE ION | non-polymer | 96.1 | 4 | Chemie (SO4) | |||
| 13 | IA, JA (G, A) | water | water | 18.0 | 785 | Chemie (HOH) |
Sequence modifications
G: 81 - 203 (UniProt: P10253)
A: 204 - 952 (UniProt: P10253)
| PDB | External Database | Details |
|---|---|---|
| Arg 199 | His 199 | conflict |
| PDB | External Database | Details |
|---|---|---|
| His 223 | Arg 223 | conflict |
| Ile 780 | Val 780 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 96996.6 | |
| Branched | Number of molecules | 5 |
| Total formula weight | 2738.6 | |
| Non-Polymers* | Number of molecules | 27 |
| Total formula weight | 2307.6 | |
| All* | Total formula weight | 102042.7 |
