4XWY

Crystal structure of human sepiapterin reductase in complex with an N-acetylserotinin analogue

Summary for 4XWY

Entry DOI	10.2210/pdb4xwy/pdb
Related	4HWK 4J7U 4J7X
Descriptor	Sepiapterin reductase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, N-[2-(5-hydroxy-2-methyl-1H-indol-3-yl)ethyl]-2-methoxyacetamide, ... (5 entities in total)
Functional Keywords	oxidoreductase, inhibitor, complex
Biological source	Homo sapiens (Human)
Cellular location	Cytoplasm: P35270
Total number of polymer chains	4
Total formula weight	124461.12
Authors	Johnsson, K.,Hovius, R.,Gorszka, K.I.,Pojer, F. (deposition date: 2015-01-29, release date: 2015-07-01, Last modification date: 2024-01-10)
Primary citation	Latremoliere, A.,Latini, A.,Andrews, N.,Cronin, S.J.,Fujita, M.,Gorska, K.,Hovius, R.,Romero, C.,Chuaiphichai, S.,Painter, M.,Miracca, G.,Babaniyi, O.,Remor, A.P.,Duong, K.,Riva, P.,Barrett, L.B.,Ferreiros, N.,Naylor, A.,Penninger, J.M.,Tegeder, I.,Zhong, J.,Blagg, J.,Channon, K.M.,Johnsson, K.,Costigan, M.,Woolf, C.J. Reduction of Neuropathic and Inflammatory Pain through Inhibition of the Tetrahydrobiopterin Pathway. Neuron, 86:1393-1406, 2015 Cited by PubMed: 26087165 DOI: 10.1016/j.neuron.2015.05.033 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.35 Å)

Structure validation