4HWK

Crystal structure of human sepiapterin reductase in complex with sulfapyridine

Summary for 4HWK

Entry DOI	10.2210/pdb4hwk/pdb
Descriptor	Sepiapterin reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, SULFATE ION, ... (7 entities in total)
Functional Keywords	reductase, oxidoreductase-antibiotic complex, oxidoreductase/antibiotic
Biological source	Homo sapiens (human)
Cellular location	Cytoplasm: P35270
Total number of polymer chains	4
Total formula weight	130852.36
Authors	Groenlund Pedersen, M.,Pojer, F.,Johnsson, K. (deposition date: 2012-11-08, release date: 2013-06-05, Last modification date: 2023-09-20)
Primary citation	Haruki, H.,Pedersen, M.G.,Gorska, K.I.,Pojer, F.,Johnsson, K. Tetrahydrobiopterin biosynthesis as an off-target of sulfa drugs. Science, 340:987-991, 2013 Cited by PubMed: 23704574 DOI: 10.1126/science.1232972 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.4 Å)

Structure validation