4XWY
Crystal structure of human sepiapterin reductase in complex with an N-acetylserotinin analogue
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B, C, D | Sepiapterin reductase | polymer | 275 | 29891.4 | 4 | UniProt (P35270) Pfam (PF00106) In PDB | Homo sapiens (Human) | SPR |
2 | A, B, C, D | NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | non-polymer | 745.4 | 4 | Chemie (NDP) | |||
3 | A, B, C, D | N-[2-(5-hydroxy-2-methyl-1H-indol-3-yl)ethyl]-2-methoxyacetamide | non-polymer | 262.3 | 4 | Chemie (43O) | |||
4 | A, B, C, D | SULFATE ION | non-polymer | 96.1 | 9 | Chemie (SO4) | |||
5 | water | water | 18.0 | 249 | Chemie (HOH) |
Sequence modifications
A, B, C, D: -2 - 258 (UniProt: P35270)
PDB | External Database | Details |
---|---|---|
Met -16 | - | initiating methionine |
His -15 | - | expression tag |
His -14 | - | expression tag |
His -13 | - | expression tag |
His -12 | - | expression tag |
His -11 | - | expression tag |
His -10 | - | expression tag |
Glu -9 | - | expression tag |
Asn -8 | - | expression tag |
Leu -7 | - | expression tag |
Tyr -6 | - | expression tag |
Phe -5 | - | expression tag |
Gln -4 | - | expression tag |
Gly -3 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 4 |
Total formula weight | 119565.7 | |
Non-Polymers* | Number of molecules | 17 |
Total formula weight | 4895.5 | |
All* | Total formula weight | 124461.1 |