PDB: 45459 件ウェブページステータス検索Chemie searchBIRD

---

5TF8	Nucleotide-binding domain 1 of the human cystic fibrosis transmembrane conductance regulator (CFTR) with dTTP 分子名称: Cystic fibrosis transmembrane conductance regulator, MAGNESIUM ION, THYMIDINE-5'-TRIPHOSPHATE 著者 Wang, C, Aleksandrov, A.A, Yang, Z, Forouhar, F, Proctor, E, Kota, P, An, J, Kaplan, A, Khazanov, N, Boel, G, Stockwell, B.R, Senderowitz, H, Dokholyan, N.V, Riordan, J.R, Brouillette, C.G, Hunt, J.F. 登録日 2016-09-24 公開日 2018-05-09 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (1.861 Å) 主引用文献 Thermodynamic correction of F508del-CFTR by ligand binding to a remote site in the mutated domain To Be Published
5TFJ	Nucleotide-binding domain 1 of the human cystic fibrosis transmembrane conductance regulator (CFTR) with dCTP 分子名称: 2'-DEOXYCYTIDINE-5'-TRIPHOSPHATE, Cystic fibrosis transmembrane conductance regulator, MAGNESIUM ION 著者 Wang, C, Aleksandrov, A.A, Yang, Z, Forouhar, F, Proctor, E, Kota, P, An, J, Kaplan, A, Khazanov, N, Boel, G, Stockwell, B.R, Senderowitz, H, Dokholyan, N.V, Riordan, J.R, Brouillette, C.G, Hunt, J.F. 登録日 2016-09-25 公開日 2018-05-09 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (1.85 Å) 主引用文献 Thermodynamic correction of F508del-CFTR by ligand binding to a remote site in the mutated domain To Be Published
5TFF	Nucleotide-binding domain 1 of the human cystic fibrosis transmembrane conductance regulator (CFTR) with UTP 分子名称: Cystic fibrosis transmembrane conductance regulator, MAGNESIUM ION, URIDINE 5'-TRIPHOSPHATE 著者 Wang, C, Aleksandrov, A.A, Yang, Z, Forouhar, F, Proctor, E, Kota, P, An, J, Kaplan, A, Khazanov, N, Boel, G, Stockwell, B.R, Senderowitz, H, Dokholyan, N.V, Riordan, J.R, Brouillette, C.G, Hunt, J.F. 登録日 2016-09-25 公開日 2018-05-09 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (1.891 Å) 主引用文献 Thermodynamic correction of F508del-CFTR by ligand binding to a remote site in the mutated domain To Be Published
5TGK	Nucleotide-binding domain 1 of the human cystic fibrosis transmembrane conductance regulator (CFTR) with dATP 分子名称: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, Cystic fibrosis transmembrane conductance regulator, MAGNESIUM ION 著者 Wang, C, Aleksandrov, A.A, Yang, Z, Forouhar, F, Proctor, E, Kota, P, An, J, Kaplan, A, Khazanov, N, Boel, G, Stockwell, B.R, Senderowitz, H, Dokholyan, N.V, Riordan, J.R, Brouillette, C.G, Hunt, J.F. 登録日 2016-09-28 公開日 2018-05-09 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (1.912 Å) 主引用文献 Ligand binding to a remote site thermodynamically corrects the F508del mutation in the human cystic fibrosis transmembrane conductance regulator. J. Biol. Chem., 2018
5T63	The HhoA protease from Synechocystis sp. PCC 6803 分子名称: ALA-ALA-ALA-ALA, MAGNESIUM ION, Putative serine protease HhoA 著者 Persson, K, Hall, M, Funk, C. 登録日 2016-09-01 公開日 2017-01-25 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 The HhoA protease from Synechocystis sp. PCC 6803 - Novel insights into structure and activity regulation. J. Struct. Biol., 198, 2017
5T69	The HhoA protease from Synechocystis sp. PCC 6803, active site mutant 分子名称: ACETATE ION, MAGNESIUM ION, Putative serine protease HhoA 著者 Persson, K, Hall, M, Funk, C. 登録日 2016-09-01 公開日 2017-01-25 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 The HhoA protease from Synechocystis sp. PCC 6803 - Novel insights into structure and activity regulation. J. Struct. Biol., 198, 2017
7S3B	Crystal structure of intact U2AF65 RRM-region bound to AdML-G5 oligonucleotide 分子名称: DI(HYDROXYETHYL)ETHER, DNA/RNA (5'-R(P*UP*UP*(UD)P*GP*U)-D(P*(BRU))-R(P*CP*C)-3'), Splicing factor U2AF 65 kDa subunit 著者 Jenkins, J.L, Henderson, S, Kielkopf, C.L. 登録日 2021-09-05 公開日 2022-05-25 最終更新日 2024-05-22 実験手法 X-RAY DIFFRACTION (1.89 Å) 主引用文献 Pre-mRNA splicing factor U2AF2 recognizes distinct conformations of nucleotide variants at the center of the pre-mRNA splice site signal. Nucleic Acids Res., 50, 2022
8C6Y	PBP AccA from A. tumefaciens Bo542 in apoform 2 分子名称: 1,2-ETHANEDIOL, Agrocinopine utilization periplasmic binding protein AccA 著者 Morera, S, Vigouroux, A, legrand, P. 登録日 2023-01-12 公開日 2024-01-24 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (1.901 Å) 主引用文献 A highly conserved ligand-binding site for AccA transporters of antibiotic and quorum-sensing regulator in Agrobacterium leads to a different specificity. Biochem.J., 481, 2024
8CB9	PBP AccA from A. tumefaciens Bo542 in complex with D-Glucose-2-phosphate 分子名称: 2-O-phosphono-alpha-D-glucopyranose, 2-O-phosphono-beta-D-glucopyranose, Agrocinopine utilization periplasmic binding protein AccA 著者 Morera, S, Vigouroux, A. 登録日 2023-01-25 公開日 2024-01-24 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (1.79 Å) 主引用文献 A highly conserved ligand-binding site for AccA transporters of antibiotic and quorum-sensing regulator in Agrobacterium leads to a different specificity. Biochem.J., 481, 2024
7S1X	Cryo-EM structure of human NKCC1 K289NA492EL671C bound with bumetanide 分子名称: 3-(butylamino)-4-phenoxy-5-sulfamoylbenzoic acid, CHLORIDE ION, POTASSIUM ION, ... 著者 Zhao, Y.X, Cao, E.H. 登録日 2021-09-02 公開日 2022-05-25 実験手法 ELECTRON MICROSCOPY (2.9 Å) 主引用文献 Structural basis for inhibition of the Cation-chloride cotransporter NKCC1 by the diuretic drug bumetanide Nat Commun, 13, 2022
8PIP	DNA triplex structure with Polypyridyl Ruthenium Complexes 分子名称: CHLORIDE ION, DNA (31-MER), Delta-Ru(phen)2(dppz) complex, ... 著者 Abdullrahman, A, Cardin, C.J, Hall, J.P. 登録日 2023-06-22 公開日 2024-07-10 最終更新日 2024-07-24 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 DNA triplex structure with bound ruthenium polypyridyl complexes To Be Published
7S1Z	Cryo-EM structure of Human NKCC1 K289NA492EL671C 分子名称: Solute carrier family 12 member 2 著者 Zhao, Y.X, Cao, E.H. 登録日 2021-09-02 公開日 2022-05-25 実験手法 ELECTRON MICROSCOPY (3.3 Å) 主引用文献 Structural basis for inhibition of the Cation-chloride cotransporter NKCC1 by the diuretic drug bumetanide Nat Commun, 13, 2022
7S1Y	Cryo-EM structure of human NKCC1 K289NA492E bound with bumetanide 分子名称: 3-(butylamino)-4-phenoxy-5-sulfamoylbenzoic acid, CHLORIDE ION, POTASSIUM ION, ... 著者 Zhao, Y.X, Cao, E.h. 登録日 2021-09-02 公開日 2022-05-25 実験手法 ELECTRON MICROSCOPY (3.6 Å) 主引用文献 Structural basis for inhibition of the Cation-chloride cotransporter NKCC1 by the diuretic drug bumetanide Nat Commun, 13, 2022
8PJW	Crystal structure of the computationally designed SAKe6FE protein 分子名称: SAKe6FE 著者 Wouters, S.M.L. 登録日 2023-06-23 公開日 2024-07-10 実験手法 X-RAY DIFFRACTION (1.65 Å) 主引用文献 Computational design of the SAKe scaffold proteins To Be Published
8COO	Solution structure of Zipcode binding protein 1 (ZBP1) KH3(DD)KH4 domains in complex with N6-Methyladenosine containing RNA 分子名称: Insulin-like growth factor 2 mRNA-binding protein 1, RNA_(5'-R(*(UP*CP*GP*GP*(6MZ)P*CP*U)-3') 著者 Nicastro, G, Abis, G, Taylor, I.A, Ramos, A. 登録日 2023-02-28 公開日 2024-02-07 実験手法 SOLUTION NMR 主引用文献 Direct m6A recognition by IMP1 underlays an alternative model of target selection for non-canonical methyl-readers. Nucleic Acids Res., 51, 2023
8EUM	MicroED structure of an Aeropyrum pernix protoglobin mutant 分子名称: FE (III) ION, IMIDAZOLE, PROTOPORPHYRIN IX CONTAINING FE, ... 著者 Danelius, E, Gonen, T, Unge, J.T. 登録日 2022-10-18 公開日 2023-11-08 最終更新日 2024-05-22 実験手法 ELECTRON CRYSTALLOGRAPHY (2.1 Å) 主引用文献 MicroED Structure of a Protoglobin Reactive Carbene Intermediate. J.Am.Chem.Soc., 145, 2023
8CEX	Structure of the mouse 8-oxoguanine DNA Glycosylase mOGG1 in complex with ligand TH11227 分子名称: 6-fluoranyl-N-[(4-methylphenyl)methyl]pyridine-3-carboxamide, N-glycosylase/DNA lyase, NICKEL (II) ION 著者 Kosenina, S, Scaletti, E.R, Stenmark, P. 登録日 2023-02-02 公開日 2024-02-21 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Structure of the mouse 8-oxoguanine DNA Glycosylase mOGG1 in complex with ligand TH11227 To Be Published
6TWN	Crystal structure of Talin1 R7R8 in complex with CDK1 (206-223) 分子名称: CHLORIDE ION, Cyclin-dependent kinase 1, GLYCEROL, ... 著者 Zacharchenko, T, Muench, S.P, Goult, B.T. 登録日 2020-01-13 公開日 2021-05-12 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2.28 Å) 主引用文献 Talin mechanosensitivity is modulated by a direct interaction with cyclin-dependent kinase-1. J.Biol.Chem., 297, 2021
6UNP	Crystal structure of the kinase domain of BMPR2-D485G 分子名称: 1,2-ETHANEDIOL, ADENOSINE-5'-DIPHOSPHATE, Bone morphogenetic protein receptor type-2, ... 著者 Agnew, C, Jura, N. 登録日 2019-10-13 公開日 2021-07-07 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Structural basis for ALK2/BMPR2 receptor complex signaling through kinase domain oligomerization. Nat Commun, 12, 2021
6TUY	Human LSD1/CoREST bound to the quinazoline inhibitor MC4106 分子名称: CHLORIDE ION, DIMETHYL SULFOXIDE, FLAVIN-ADENINE DINUCLEOTIDE, ... 著者 Mattevi, A, Marrocco, B. 登録日 2020-01-08 公開日 2021-07-21 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Novel non-covalent LSD1 inhibitors endowed with anticancer effects in leukemia and solid tumor cellular models. Eur.J.Med.Chem., 237, 2022
7RWE	Crystal structure of CDK2 liganded with compound GPHR787 分子名称: 5-nitro-2-[(3-phenylpropyl)amino]benzoic acid, Cyclin-dependent kinase 2 著者 Sun, L, Schonbrunn, E. 登録日 2021-08-19 公開日 2022-08-24 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (1.59 Å) 主引用文献 Screening through Lead Optimization of High Affinity, Allosteric Cyclin-Dependent Kinase 2 (CDK2) Inhibitors as Male Contraceptives That Reduce Sperm Counts in Mice. J.Med.Chem., 66, 2023
6TW7	Leishmania major N-myristoyltransferase in complex with indazole inhibitor IMP-918 分子名称: Glycylpeptide N-tetradecanoyltransferase, MAGNESIUM ION, TETRADECANOYL-COA, ... 著者 Brannigan, J.A. 登録日 2020-01-12 公開日 2021-07-21 最終更新日 2024-05-15 実験手法 X-RAY DIFFRACTION (1.4 Å) 主引用文献 Leishmania major N-myristoyltransferase in complex with indazole inhibitor IMP-918 To Be Published
6TW8	Leishmania major N-myristoyltransferase in complex with indazole inhibitor IMP-917 分子名称: 1-[5-[4-fluoranyl-2-[2-(1,3,5-trimethylpyrazol-4-yl)ethoxy]phenyl]-2~{H}-indazol-3-yl]-~{N},~{N}-dimethyl-methanamine, Glycylpeptide N-tetradecanoyltransferase, MAGNESIUM ION, ... 著者 Brannigan, J.A. 登録日 2020-01-12 公開日 2021-07-21 最終更新日 2024-05-15 実験手法 X-RAY DIFFRACTION (1.79 Å) 主引用文献 Leishmania major N-myristoyltransferase in complex with indazole inhibitor IMP-917 To Be Published
6TWG	Solution structure of antimicrobial peptide, crabrolin Plus in the presence of Lipopolysaccharide 分子名称: Crabrolin Plus, mutant of Crabrolin peptide 著者 Cantini, F, Bouchemal, N, Savarin, P, Sette, M. 登録日 2020-01-13 公開日 2020-07-22 最終更新日 2024-06-19 実験手法 SOLUTION NMR 主引用文献 Effect of positive charges in the structural interaction of crabrolin isoforms with lipopolysaccharide. J.Pept.Sci., 26, 2020
8PSR	ERK2 covalently bound to SynthRevD-12-opt artificial peptide 分子名称: GLYCEROL, Mitogen-activated protein kinase 1, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ... 著者 Sok, P, Poti, A, Gogl, G, Remenyi, A. 登録日 2023-07-13 公開日 2024-07-24 実験手法 X-RAY DIFFRACTION (1.85 Å) 主引用文献 Targeting a key protein-protein interaction surface on mitogen-activated protein kinases by a Michael acceptor-based cyclic warhead scaffold To Be Published

<1514151515161517151815191520152115221523152415251526152715281529>