5TGK
Nucleotide-binding domain 1 of the human cystic fibrosis transmembrane conductance regulator (CFTR) with dATP
Summary for 5TGK
| Entry DOI | 10.2210/pdb5tgk/pdb |
| Related | 5TF7 5TF8 5TFA 5TFB 5TFC 5TFD 5TFE 5TFF 5TFG 5TFH 5TFI 5TFJ |
| Descriptor | Cystic fibrosis transmembrane conductance regulator, MAGNESIUM ION, 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, ... (4 entities in total) |
| Functional Keywords | hnbd1, cftr, abc transport, datp, hydrolase |
| Biological source | Homo sapiens (Human) |
| Total number of polymer chains | 1 |
| Total formula weight | 26040.90 |
| Authors | Wang, C.,Aleksandrov, A.A.,Yang, Z.,Forouhar, F.,Proctor, E.,Kota, P.,An, J.,Kaplan, A.,Khazanov, N.,Boel, G.,Stockwell, B.R.,Senderowitz, H.,Dokholyan, N.V.,Riordan, J.R.,Brouillette, C.G.,Hunt, J.F. (deposition date: 2016-09-28, release date: 2018-05-09, Last modification date: 2023-10-04) |
| Primary citation | Wang, C.,Aleksandrov, A.A.,Yang, Z.,Forouhar, F.,Proctor, E.A.,Kota, P.,An, J.,Kaplan, A.,Khazanov, N.,Boel, G.,Stockwell, B.R.,Senderowitz, H.,Dokholyan, N.V.,Riordan, J.R.,Brouillette, C.G.,Hunt, J.F. Ligand binding to a remote site thermodynamically corrects the F508del mutation in the human cystic fibrosis transmembrane conductance regulator. J. Biol. Chem., 2018 Cited by PubMed: 29903914DOI: 10.1074/jbc.RA117.000819 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.912 Å) |
Structure validation
Download full validation report
