5TFF
Nucleotide-binding domain 1 of the human cystic fibrosis transmembrane conductance regulator (CFTR) with UTP
Summary for 5TFF
Entry DOI | 10.2210/pdb5tff/pdb |
Related | 5TF7 5TF8 5TFA 5TFB 5TFC 5TFD 5TFE 5TFG 5TFH 5TFI 5TFJ 5TGK |
Descriptor | Cystic fibrosis transmembrane conductance regulator, MAGNESIUM ION, URIDINE 5'-TRIPHOSPHATE, ... (4 entities in total) |
Functional Keywords | hnbd1, cftr, abc transport, atp, hydrolase |
Biological source | Homo sapiens (Human) |
Cellular location | Apical cell membrane ; Multi-pass membrane protein {ECO:0000269|Ref: P13569 |
Total number of polymer chains | 1 |
Total formula weight | 26033.85 |
Authors | Wang, C.,Aleksandrov, A.A.,Yang, Z.,Forouhar, F.,Proctor, E.,Kota, P.,An, J.,Kaplan, A.,Khazanov, N.,Boel, G.,Stockwell, B.R.,Senderowitz, H.,Dokholyan, N.V.,Riordan, J.R.,Brouillette, C.G.,Hunt, J.F. (deposition date: 2016-09-25, release date: 2018-05-09, Last modification date: 2023-10-04) |
Primary citation | Wang, C.,Aleksandrov, A.A.,Yang, Z.,Forouhar, F.,Proctor, E.,Kota, P.,An, J.,Kaplan, A.,Khazanov, N.,Boel, G.,Stockwell, B.R.,Senderowitz, H.,Dokholyan, N.V.,Riordan, J.R.,Brouillette, C.G.,Hunt, J.F. Thermodynamic correction of F508del-CFTR by ligand binding to a remote site in the mutated domain To Be Published, |
Experimental method | X-RAY DIFFRACTION (1.891 Å) |
Structure validation
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