5TFF

Nucleotide-binding domain 1 of the human cystic fibrosis transmembrane conductance regulator (CFTR) with UTP

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Cystic fibrosis transmembrane conductance regulator	polymer	229	25525.4	1	UniProt (P13569) Pfam (PF00005) In PDB	Homo sapiens (Human)	CFTR,ATP-binding cassette sub-family C member 7,Channel conductance-controlling ATPase,cAMP-dependent chloride channel
2	A	MAGNESIUM ION	non-polymer		24.3	1	Chemie (MG)
3	A	URIDINE 5'-TRIPHOSPHATE	non-polymer		484.1	1	Chemie (UTP)
4		water	water		18.0	196	Chemie (HOH)

Sequence modifications

A: 387 - 646 (UniProt: P13569)

PDB	External Database	Details
Ser 386	-	expression tag
-	Phe 405	deletion
-	Gly 406	deletion
-	Glu 407	deletion
-	Leu 408	deletion
-	Phe 409	deletion
-	Glu 410	deletion
-	Lys 411	deletion
-	Ala 412	deletion
-	Lys 413	deletion
-	Gln 414	deletion
-	Asn 415	deletion
-	Asn 416	deletion
-	Asn 417	deletion
-	Asn 418	deletion
-	Arg 419	deletion
-	Lys 420	deletion
-	Thr 421	deletion
-	Ser 422	deletion
-	Asn 423	deletion
-	Gly 424	deletion
-	Asp 425	deletion
-	Asp 426	deletion
-	Ser 427	deletion
-	Leu 428	deletion
-	Phe 429	deletion
-	Phe 430	deletion
-	Ser 431	deletion
-	Asn 432	deletion
-	Phe 433	deletion
-	Ser 434	deletion
-	Leu 435	deletion
-	Leu 436	deletion
Met 470	Val 470	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	25525.4
Non-Polymers*	Number of molecules	2
	Total formula weight	508.4
All*	Total formula weight	26033.9

*Water molecules are not included.