8PSR

ERK2 covalently bound to SynthRevD-12-opt artificial peptide

Summary for 8PSR

• Entry DOI: 10.2210/pdb8psr/pdb
• Descriptor: Mitogen-activated protein kinase 1, SynthRevD-12-opt, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ... (5 entities in total)
• Functional Keywords: mapk kinase, mapk, inhibitor, covalent, erk2, michael acceptor warhead, signaling protein
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 2
• Total formula weight: 44871.22

Authors

Sok, P.,Poti, A.,Gogl, G.,Remenyi, A. (deposition date: 2023-07-13, release date: 2024-07-24)

• Primary citation: Sok, P.,Poti, A.,Balint, D.,Soos, T.,Remenyi, A.; Targeting a key protein-protein interaction surface on mitogen-activated protein kinases by a Michael acceptor-based cyclic warhead scaffold; To Be Published,

Experimental method

X-RAY DIFFRACTION (1.85 Å)