PDB: 592 件ウェブページステータス検索Chemie searchBIRD

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6RJ7	Crystal structure of the 19F labelled OXA-48 分子名称: Beta-lactamase, CALCIUM ION, CHLORIDE ION 著者 Brem, J, Lohans, C, Schofield, C. 登録日 2019-04-26 公開日 2019-07-31 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.73002231 Å) 主引用文献 19F NMR Monitoring of Reversible Protein Post-Translational Modifications: Class D beta-Lactamase Carbamylation and Inhibition. Chemistry, 25, 2019
6P56	Crystal structure of the transpeptidase domain of a T498A mutant of PBP2 from Neisseria gonorrhoeae 分子名称: PHOSPHATE ION, peptidoglycan D,D-transpeptidase PenA 著者 Singh, A, Davies, C. 登録日 2019-05-29 公開日 2019-08-07 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (1.92 Å) 主引用文献 Recognition of the beta-lactam carboxylate triggers acylation ofNeisseria gonorrhoeaepenicillin-binding protein 2. J.Biol.Chem., 294, 2019
6P52	Crystal structure of transpeptidase domain of PBP2 from Neisseria gonorrhoeae with a bound phosphate at the active site 分子名称: PHOSPHATE ION, peptidoglycan D,D-transpeptidase PenA 著者 Singh, A, Davies, C. 登録日 2019-05-29 公開日 2019-08-07 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.83 Å) 主引用文献 Recognition of the beta-lactam carboxylate triggers acylation ofNeisseria gonorrhoeaepenicillin-binding protein 2. J.Biol.Chem., 294, 2019
6P53	Crystal structure of the transpeptidase domain of PBP2 from Neisseria gonorrhoeae in apo form 分子名称: PHOSPHATE ION, peptidoglycan D,D-transpeptidase PenA 著者 Singh, A, Davies, C. 登録日 2019-05-29 公開日 2019-08-07 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.92 Å) 主引用文献 Recognition of the beta-lactam carboxylate triggers acylation ofNeisseria gonorrhoeaepenicillin-binding protein 2. J.Biol.Chem., 294, 2019
6P96	OXA-48 carbapanemase, apo form 分子名称: Beta-lactamase, CADMIUM ION, CALCIUM ION, ... 著者 Smith, C.A, Vakulenko, S.B. 登録日 2019-06-10 公開日 2019-08-07 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 Structural Insights into the Mechanism of Carbapenemase Activity of the OXA-48 beta-Lactamase. Antimicrob.Agents Chemother., 63, 2019
6P9C	OXA-48 carbapanemase, doripenem complex 分子名称: (4R,5S)-5-[(2S,3R)-3-hydroxy-1-oxobutan-2-yl]-4-methyl-3-({(3S,5S)-5-[(sulfamoylamino)methyl]pyrrolidin-3-yl}sulfanyl)-4,5-dihydro-1H-pyrrole-2-carboxylic acid, Beta-lactamase, CADMIUM ION, ... 著者 Smith, C.A, Vakulenko, S.B. 登録日 2019-06-10 公開日 2019-08-07 最終更新日 2019-10-09 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Structural Insights into the Mechanism of Carbapenemase Activity of the OXA-48 beta-Lactamase. Antimicrob.Agents Chemother., 63, 2019
6P54	Crystal structure of transpeptidase domain of PBP2 from Neisseria gonorrhoeae acylated by ceftriaxone 分子名称: CEFOTAXIME, C3' cleaved, open, ... 著者 Singh, A, Davies, C. 登録日 2019-05-29 公開日 2019-08-07 最終更新日 2020-01-01 実験手法 X-RAY DIFFRACTION (1.83 Å) 主引用文献 Recognition of the beta-lactam carboxylate triggers acylation ofNeisseria gonorrhoeaepenicillin-binding protein 2. J.Biol.Chem., 294, 2019
6P55	Crystal structure of transpeptidase domain of PBP2 from Neisseria gonorrhoeae acylated by cefixime 分子名称: DI(HYDROXYETHYL)ETHER, PHOSPHATE ION, cefixime, ... 著者 Singh, A, Davies, C. 登録日 2019-05-29 公開日 2019-08-07 最終更新日 2020-01-01 実験手法 X-RAY DIFFRACTION (1.74 Å) 主引用文献 Recognition of the beta-lactam carboxylate triggers acylation ofNeisseria gonorrhoeaepenicillin-binding protein 2. J.Biol.Chem., 294, 2019
6P99	OXA-48 carbapanemase, ertapenem complex 分子名称: (4R,5S)-3-({(3S,5S)-5-[(3-carboxyphenyl)carbamoyl]pyrrolidin-3-yl}sulfanyl)-5-[(1S,2R)-1-formyl-2-hydroxypropyl]-4-methyl-4,5-dihydro-1H-pyrrole-2-carboxylic acid, Beta-lactamase, CADMIUM ION, ... 著者 Smith, C.A, Vakulenko, S.B. 登録日 2019-06-10 公開日 2019-08-07 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (2.25 Å) 主引用文献 Structural Insights into the Mechanism of Carbapenemase Activity of the OXA-48 beta-Lactamase. Antimicrob.Agents Chemother., 63, 2019
6P98	OXA-48 carbapanemase, meropenem complex 分子名称: Beta-lactamase, CADMIUM ION, CALCIUM ION, ... 著者 Smith, C.A, Vakulenko, S.B. 登録日 2019-06-10 公開日 2019-08-07 最終更新日 2019-10-09 実験手法 X-RAY DIFFRACTION (1.75 Å) 主引用文献 Structural Insights into the Mechanism of Carbapenemase Activity of the OXA-48 beta-Lactamase. Antimicrob.Agents Chemother., 63, 2019
6P97	OXA-48 carbapanemase, imipenem complex 分子名称: (5R)-5-[(1S,2R)-1-formyl-2-hydroxypropyl]-3-[(2-{[(E)-iminomethyl]amino}ethyl)sulfanyl]-4,5-dihydro-1H-pyrrole-2-carboxylic acid, Beta-lactamase, CADMIUM ION, ... 著者 Smith, C.A, Vakulenko, S.B. 登録日 2019-06-10 公開日 2019-08-07 最終更新日 2019-10-09 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Structural Insights into the Mechanism of Carbapenemase Activity of the OXA-48 beta-Lactamase. Antimicrob.Agents Chemother., 63, 2019
6H5O	Crystal structure of PBP2a from MRSA in complex with piperacillin at active site. 分子名称: CADMIUM ION, Penicillin binding protein 2 prime, Piperacillin (Open Form) 著者 Batuecas, M.T, Martinez-Caballero, S, Hermoso, J.A. 登録日 2018-07-25 公開日 2019-08-14 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2.82 Å) 主引用文献 The Quinazolinone Allosteric Inhibitor of PBP 2a Synergizes with Piperacillin and Tazobactam against Methicillin-Resistant Staphylococcus aureus. Antimicrob.Agents Chemother., 63, 2019
6HB8	Crystal structure of OXA-517 beta-lactamase 分子名称: 1,2-ETHANEDIOL, 2-ETHOXYETHANOL, Beta-lactamase, ... 著者 Raczynska, J.E, Dabos, L, Zavala, A, Retailleau, P, Iorga, B, Jaskolski, M, Naas, T. 登録日 2018-08-09 公開日 2019-08-28 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (1.86 Å) 主引用文献 Genetic, biochemical and structural characterization of OXA-517, an OXA-48-like extended-spectrum cephalosporins and carbapenems-hydrolyzing beta-lactamase To Be Published
6RTN	Crystal structure of OXA-10 with VNRX-5133 分子名称: (3~{R})-3-[2-[4-(2-azanylethylamino)cyclohexyl]ethanoylamino]-2-oxidanyl-3,4-dihydro-1,2-benzoxaborinine-8-carboxylic acid, Beta-lactamase OXA-10, CHLORIDE ION 著者 Brem, J, Schofield, C. 登録日 2019-05-24 公開日 2019-09-11 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2.17 Å) 主引用文献 Bicyclic Boronate VNRX-5133 Inhibits Metallo- and Serine-beta-Lactamases. J.Med.Chem., 62, 2019
6SKP	OXA-10_IPM. Structural insight to the enhanced carbapenem efficiency of OXA-655 compared to OXA-10. 分子名称: (5R)-5-[(1S,2R)-1-formyl-2-hydroxypropyl]-3-[(2-{[(E)-iminomethyl]amino}ethyl)sulfanyl]-4,5-dihydro-1H-pyrrole-2-carbox ylic acid, Beta-lactamase, SODIUM ION, ... 著者 Leiros, H.-K.S. 登録日 2019-08-16 公開日 2019-09-18 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.891 Å) 主引用文献 Structural insights into the enhanced carbapenemase efficiency of OXA-655 compared to OXA-10. Febs Open Bio, 10, 2020
6SKR	OXA-10_ETP. Structural insight to the enhanced carbapenem efficiency of OXA-655 compared to OXA-10. 分子名称: (4R,5S)-3-({(3S,5S)-5-[(3-carboxyphenyl)carbamoyl]pyrrolidin-3-yl}sulfanyl)-5-[(1S,2R)-1-formyl-2-hydroxypropyl]-4-methyl-4,5-dihydro-1H-pyrrole-2-carboxylic acid, Beta-lactamase, FORMIC ACID, ... 著者 Leiros, H.-K.S. 登録日 2019-08-16 公開日 2019-09-18 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.85 Å) 主引用文献 Structural insights into the enhanced carbapenemase efficiency of OXA-655 compared to OXA-10. Febs Open Bio, 10, 2020
6SKQ	OXA-655_MEM. Structural insights into the enhanced carbapenemase efficiency of OXA-655 compared to OXA-10. 分子名称: (4R,5S)-3-{[(3S,5S)-5-(dimethylcarbamoyl)pyrrolidin-3-yl]sulfanyl}-5-[(2S,3R)-3-hydroxy-1-oxobutan-2-yl]-4-methyl-4,5-d ihydro-1H-pyrrole-2-carboxylic acid, Beta-lactamase, SULFATE ION 著者 Leiros, H.-K.S. 登録日 2019-08-16 公開日 2019-09-18 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Structural insights into the enhanced carbapenemase efficiency of OXA-655 compared to OXA-10. Febs Open Bio, 10, 2020
6PXX	Class D beta-lactamase in complex with beta-lactam antibiotic 分子名称: (2~{S},3~{R})-3-methyl-2-[(2~{S},3~{R})-3-oxidanyl-1-oxidanylidene-butan-2-yl]-4-[(3~{S},5~{S})-5-[(sulfamoylamino)methyl]pyrrolidin-3-yl]sulfanyl-3,4-dihydro-2~{H}-pyrrole-5-carboxylic acid, 1,2-ETHANEDIOL, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ... 著者 van den Akker, F, Kumar, V. 登録日 2019-07-28 公開日 2019-10-09 実験手法 X-RAY DIFFRACTION (1.5 Å) 主引用文献 Structural Analysis of The OXA-48 Carbapenemase Bound to A "Poor" Carbapenem Substrate, Doripenem. Antibiotics, 8, 2019
6HOO	Crystal Structure of Rationally Designed OXA-48loop18 beta-lactamase 分子名称: Beta-lactamase,OXA-48loop18,Beta-lactamase, FLUORIDE ION, GLYCEROL, ... 著者 Zavala, A, Retailleau, P, Dabos, L, Naas, T, Iorga, B. 登録日 2018-09-17 公開日 2019-10-09 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2.38 Å) 主引用文献 Substrate Specificity of OXA-48 after beta 5-beta 6 Loop Replacement. Acs Infect Dis., 6, 2020
6HR9	Nitrocefin acylation of both catalytic serines of the Y409 mutant of penicillin-binding protein 3 from P. aeruginosa 分子名称: Nitrocefin - open form, Peptidoglycan D,D-transpeptidase FtsI 著者 Bellini, D, Dowson, C.G. 登録日 2018-09-26 公開日 2019-10-23 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.99 Å) 主引用文献 Nitrocefin acylation of both catalytic serines of penicillin-binding protein 3 from P. aeruginosa To Be Published
6HR6	Nitrocefin reacted with catalytic serine (Ser294) of penicillin-binding protein 3 from Pseudomonas aeruginosa 分子名称: Nitrocefin - open form, Peptidoglycan D,D-transpeptidase FtsI 著者 Bellini, D, Dowson, C.G. 登録日 2018-09-26 公開日 2019-10-23 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2.53 Å) 主引用文献 Nitrocefin acylation of single catalytic serine of penicillin-binding protein 3 from P. aeruginosa To Be Published
6HR4	Apo form of penicillin-binding protein 3 from P. aeruginosa 分子名称: Peptidoglycan D,D-transpeptidase FtsI 著者 Bellini, D, Dowson, C.G. 登録日 2018-09-26 公開日 2019-10-23 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.19 Å) 主引用文献 Apo form of penicillin-binding protein 3 from P. aeruginosa To Be Published
6HUH	CRYSTAL STRUCTURE OF OXA-427 class D BETA-LACTAMASE 分子名称: Beta-lactamase, SULFATE ION 著者 Zavala, A, Retailleau, P, Bogaerts, P, Glupczynski, Y, Naas, T, Iorga, B. 登録日 2018-10-08 公開日 2019-10-30 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2.78 Å) 主引用文献 CRYSTAL STRUCTURE OF CMY-OXA-427-HisTag BETA-LACTAMASE To be published
6UN3	Crystal structure of Pseudomonas aeruginosa PBP3 in complex with ticarcillin 分子名称: (2R,4S)-2-[(1R)-1-{[(2R)-2-carboxy-2-(thiophen-3-yl)acetyl]amino}-2-oxoethyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid, CALCIUM ION, GLYCEROL, ... 著者 Sacco, M, Chen, Y. 登録日 2019-10-10 公開日 2019-10-30 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Influence of the alpha-Methoxy Group on the Reaction of Temocillin with Pseudomonas aeruginosa PBP3 and CTX-M-14 beta-Lactamase. Antimicrob.Agents Chemother., 64, 2019
6UN1	Crystal structure of Pseudomonas aeruginosa PBP3 in complex with temocillin 分子名称: (2R,4S)-2-[(1S)-1-{[(2R)-2-carboxy-2-(thiophen-3-yl)acetyl]amino}-1-methoxy-2-oxoethyl]-5,5-dimethyl-1,3-thiazolidine-4 -carboxylic acid, Peptidoglycan D,D-transpeptidase FtsI 著者 Sacco, M, Chen, Y. 登録日 2019-10-10 公開日 2019-10-30 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.26 Å) 主引用文献 Influence of the alpha-Methoxy Group on the Reaction of Temocillin with Pseudomonas aeruginosa PBP3 and CTX-M-14 beta-Lactamase. Antimicrob.Agents Chemother., 64, 2019

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