6PXX

Class D beta-lactamase in complex with beta-lactam antibiotic

Summary for 6PXX

• Entry DOI: 10.2210/pdb6pxx/pdb
• Descriptor: Beta-lactamase, (2~{S},3~{R})-3-methyl-2-[(2~{S},3~{R})-3-oxidanyl-1-oxidanylidene-butan-2-yl]-4-[(3~{S},5~{S})-5-[(sulfamoylamino)methyl]pyrrolidin-3-yl]sulfanyl-3,4-dihydro-2~{H}-pyrrole-5-carboxylic acid, 1,2-ETHANEDIOL, ... (6 entities in total)
• Functional Keywords: inhibitor, lactamase, hydrolase, hydrolase-antibiotic-inhibitor complex, hydrolase/antibiotic/inhibitor
• Biological source: Klebsiella pneumoniae
• Total number of polymer chains: 2
• Total formula weight: 62141.84

Authors

van den Akker, F.,Kumar, V. (deposition date: 2019-07-28, release date: 2019-10-09)

• Primary citation: Papp-Wallace, K.M.,Kumar, V.,Zeiser, E.T.,Becka, S.A.,van den Akker, F.; Structural Analysis of The OXA-48 Carbapenemase Bound to A "Poor" Carbapenem Substrate, Doripenem.; Antibiotics, 8:-, 2019; PubMed: 31514291; DOI: 10.3390/antibiotics8030145

Experimental method

X-RAY DIFFRACTION (1.5 Å)