6PXX

Class D beta-lactamase in complex with beta-lactam antibiotic

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0008658	molecular_function	penicillin binding
A	0008800	molecular_function	beta-lactamase activity
B	0008658	molecular_function	penicillin binding
B	0008800	molecular_function	beta-lactamase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	14
Details	binding site for residue 5R7 A 301

Chain	Residue
A	ALA69
A	HOH404
A	HOH413
A	HOH531
A	HOH548
A	HOH628
A	SER70
A	ILE102
A	TRP105
A	VAL120
A	GLY210
A	TYR211
A	SER244
A	ARG250

---

site_id	AC2
Number of Residues	6
Details	binding site for residue EDO A 302

Chain	Residue
A	ALA65
A	PHE66
A	HOH411
A	HOH437
A	HOH450
A	HOH479

---

site_id	AC3
Number of Residues	7
Details	binding site for residue EDO A 303

Chain	Residue
A	ASP229
A	ASP230
A	HOH517
A	HOH556
B	ASP108
B	HIS109
B	ASN110

---

site_id	AC4
Number of Residues	8
Details	binding site for residue EDO A 304

Chain	Residue
A	GLN124
A	SER155
A	SER155
A	LEU158
A	ASP159
A	ASP159
A	ARG214
A	ARG214

---

site_id	AC5
Number of Residues	8
Details	binding site for residue EDO A 305

Chain	Residue
A	LYS39
A	SER40
A	MET239
A	ASP240
A	MET241
A	PRO242
A	HOH414
A	HOH493

---

site_id	AC6
Number of Residues	2
Details	binding site for residue CL A 306

Chain	Residue
A	ARG206
B	ARG206

---

site_id	AC7
Number of Residues	7
Details	binding site for residue EPE B 302

Chain	Residue
B	ASP101
B	ILE102
B	VAL120
B	ARG214
B	5R7301
B	HOH447
B	HOH512

---

site_id	AC8
Number of Residues	6
Details	binding site for residue EDO B 303

Chain	Residue
A	HIS109
A	ASN110
B	ASP229
B	ASP230
B	HOH478
B	HOH495

---

site_id	AC9
Number of Residues	4
Details	binding site for residue CL B 304

Chain	Residue
B	TYR123
B	TRP157
B	HOH641
B	HOH667

---

site_id	AD1
Number of Residues	22
Details	binding site for Di-peptide 5R7 B 301 and SER B 70

Chain	Residue
B	PRO68
B	ALA69
B	THR71
B	PHE72
B	ALA73
B	ILE102
B	TRP105
B	TYR117
B	SER118
B	VAL120
B	LEU158
B	LYS208
B	THR209
B	GLY210
B	TYR211
B	ARG250
B	EPE302
B	HOH401
B	HOH403
B	HOH406
B	HOH419
B	HOH450

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	Active site: {"description":"Acyl-ester intermediate","evidences":[{"source":"PIRSR","id":"PIRSR602137-50","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"25406838","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26731698","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31358584","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32150407","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4WMC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5FAQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5FAS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6P97","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6P98","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6P99","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6P9C","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6V1O","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	6
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"Q8RLA6","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"P13661","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	Modified residue: {"description":"N6-carboxylysine","evidences":[{"source":"PIRSR","id":"PIRSR602137-50","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"19477418","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25406838","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3HBR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4WMC","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---