6RTN

Crystal structure of OXA-10 with VNRX-5133

Summary for 6RTN

Entry DOI	10.2210/pdb6rtn/pdb
Descriptor	Beta-lactamase OXA-10, CHLORIDE ION, (3~{R})-3-[2-[4-(2-azanylethylamino)cyclohexyl]ethanoylamino]-2-oxidanyl-3,4-dihydro-1,2-benzoxaborinine-8-carboxylic acid, ... (4 entities in total)
Functional Keywords	beta lactamase, antibiotic resistance, boronates, antimicrobial protein
Biological source	Pseudomonas aeruginosa
Total number of polymer chains	2
Total formula weight	56600.92
Authors	Brem, J.,Schofield, C. (deposition date: 2019-05-24, release date: 2019-09-11, Last modification date: 2024-01-24)
Primary citation	Krajnc, A.,Brem, J.,Hinchliffe, P.,Calvopina, K.,Panduwawala, T.D.,Lang, P.A.,Kamps, J.J.A.G.,Tyrrell, J.M.,Widlake, E.,Saward, B.G.,Walsh, T.R.,Spencer, J.,Schofield, C.J. Bicyclic Boronate VNRX-5133 Inhibits Metallo- and Serine-beta-Lactamases. J.Med.Chem., 62:8544-8556, 2019 Cited by PubMed: 31454231 DOI: 10.1021/acs.jmedchem.9b00911 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.17 Å)

Structure validation