PDB: 45459 件ウェブページステータス検索Chemie searchBIRD

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4S25	Crystal structure of Arabidopsis thaliana ThiC with bound imidazole ribonucleotide, S-adenosylhomocysteine, Fe4S4 cluster and Zn (trigonal crystal form) 分子名称: 1,4-BUTANEDIOL, 1-(5-O-phosphono-beta-D-ribofuranosyl)-1H-imidazole, CHLORIDE ION, ... 著者 Fenwick, M.K, Mehta, A.P, Zhang, Y, Abdelwahed, S, Begley, T.P, Ealick, S.E. 登録日 2015-01-19 公開日 2015-04-08 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.45 Å) 主引用文献 Non-canonical active site architecture of the radical SAM thiamin pyrimidine synthase. Nat Commun, 6
7OFV	NMR-guided design of potent and selective EphA4 agonistic ligands 分子名称: ACETATE ION, EphA4 agonist ligand, Ephrin type-A receptor 4 著者 Ganichkin, O.M, Craig, T.K, Baggio, C, Pellecchia, M. 登録日 2021-05-05 公開日 2021-08-11 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.43 Å) 主引用文献 NMR-Guided Design of Potent and Selective EphA4 Agonistic Ligands. J.Med.Chem., 64, 2021
4TRM	Structure of the apo form of InhA from Mycobacterium tuberculosis 分子名称: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, Enoyl-[acyl-carrier-protein] reductase [NADH] 著者 Chollet, A, Julien, S, Mourey, L, Maveyraud, L. 登録日 2014-06-17 公開日 2015-04-29 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Crystal structure of the enoyl-ACP reductase of Mycobacterium tuberculosis (InhA) in the apo-form and in complex with the active metabolite of isoniazid pre-formed by a biomimetic approach. J.Struct.Biol., 190, 2015
5YE9	The crystal structure of Lp-PLA2 in complex with a novel inhibitor 分子名称: N-[4-[(3-cyano-4-naphthalen-2-yloxy-phenyl)sulfamoyl]phenyl]ethanamide, Platelet-activating factor acetylhydrolase, SULFATE ION 著者 Liu, Q.F, Xu, Y.C. 登録日 2017-09-15 公開日 2018-07-25 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (1.876 Å) 主引用文献 Structure-Guided Discovery of Novel, Potent, and Orally Bioavailable Inhibitors of Lipoprotein-Associated Phospholipase A2. J. Med. Chem., 60, 2017
4RKE	Drosophila melanogaster Rab2 bound to GMPPNP 分子名称: GH01619p, MAGNESIUM ION, PENTAETHYLENE GLYCOL, ... 著者 Lardong, J.A, Driller, J.H, Depner, H, Weise, C, Petzoldt, A, Wahl, M.C, Sigrist, S.J, Loll, B. 登録日 2014-10-13 公開日 2014-12-10 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.0006 Å) 主引用文献 Structures of Drosophila melanogaster Rab2 and Rab3 bound to GMPPNP. Acta Crystallogr F Struct Biol Commun, 71, 2015
7NY0	Solution structure of Boskar4; a de novo designed G-CSF agonist 分子名称: Boskar4 著者 ElGamacy, M, Coles, M. 登録日 2021-03-19 公開日 2021-10-06 最終更新日 2024-06-19 実験手法 SOLUTION NMR 主引用文献 A topological refactoring design strategy yields highly stable granulopoietic proteins. Nat Commun, 13, 2022
7NXP	Structure of the C-terminal domain of the pUL77 capsid protein from human cytomegalovirus (HCMV) 分子名称: Capsid vertex component 2, GLYCEROL 著者 Naniima, P, Legrand, P, Krey, T. 登録日 2021-03-19 公開日 2021-10-13 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.896 Å) 主引用文献 Assembly of infectious Kaposi's sarcoma-associated herpesvirus progeny requires formation of a pORF19 pentamer. Plos Biol., 19, 2021
7OJ6	Crystal structure of Pseudomonas aeruginosa LpxA in complex with compound 1 分子名称: 2-[2-(2-chlorophenyl)sulfanylethanoyl-[[4-(1,2,4-triazol-1-yl)phenyl]methyl]amino]-N-methyl-ethanamide, ACETATE ION, Acyl-[acyl-carrier-protein]-UDP-N-acetylglucosamine O-acyltransferase, ... 著者 Ryan, M.D, Parkes, A.L, Southey, M, Andersen, O.A, Zahn, M, Barker, J, DeJonge, B.L.M. 登録日 2021-05-14 公開日 2021-10-13 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.84 Å) 主引用文献 Discovery of Novel UDP- N -Acetylglucosamine Acyltransferase (LpxA) Inhibitors with Activity against Pseudomonas aeruginosa . J.Med.Chem., 64, 2021
5Y9T	Crystal Structure of EGFR T790M mutant in complex with naquotinib 分子名称: 6-ethyl-3-[[4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]phenyl]amino]-5-[(3R)-1-prop-2-enoylpyrrolidin-3-yl]oxy-pyrazin e-2-carboxamide, Epidermal growth factor receptor 著者 Mimasu, S, Tomimoto, Y, Maiko, I, Yasushi, A, Tatsuya, N. 登録日 2017-08-28 公開日 2018-07-11 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (3.25 Å) 主引用文献 Pharmacological and Structural Characterizations of Naquotinib, a Novel Third-Generation EGFR Tyrosine Kinase Inhibitor, inEGFR-Mutated Non-Small Cell Lung Cancer. Mol. Cancer Ther., 17, 2018
5YE7	The crystal structure of Lp-PLA2 in complex with a novel inhibitor 分子名称: N-[4-[(4-naphthalen-2-yloxyphenyl)sulfamoyl]phenyl]ethanamide, Platelet-activating factor acetylhydrolase, SULFATE ION 著者 Liu, Q.F, Xu, Y.C. 登録日 2017-09-15 公開日 2018-07-25 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2.312 Å) 主引用文献 Structure-Guided Discovery of Novel, Potent, and Orally Bioavailable Inhibitors of Lipoprotein-Associated Phospholipase A2. J. Med. Chem., 60, 2017
5YGG	Crystal structure of Fructokinase Double-Mutant (T261C-H108C) from Vibrio cholerae O395 in fructose, ADP and potassium ion bound form 分子名称: ADENOSINE-5'-DIPHOSPHATE, CALCIUM ION, Fructokinase, ... 著者 Chatterjee, S, Paul, R, Nath, S, Sen, U. 登録日 2017-09-22 公開日 2018-09-26 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (1.671 Å) 主引用文献 Large-scale conformational changes and redistribution of surface negative charge upon sugar binding dictate the fidelity of phosphorylation in Vibrio cholerae fructokinase. Sci Rep, 8, 2018
4TRJ	Crystal structure of Mycobacterium tuberculosis enoyl reductase (INHA) complexed with N-(3-bromophenyl)-1-cyclohexyl-5-oxopyrrolidine-3-carboxamide, refined with new ligand restraints 分子名称: (3S)-N-(3-BROMOPHENYL)-1-CYCLOHEXYL-5-OXOPYRROLIDINE-3-CARBOXAMIDE, Enoyl-[acyl-carrier-protein] reductase [NADH], NICOTINAMIDE-ADENINE-DINUCLEOTIDE 著者 He, X, Alian, A, Stroud, R.M, Ortiz de Montellano, P.R. 登録日 2014-06-17 公開日 2014-08-13 最終更新日 2023-12-27 実験手法 X-RAY DIFFRACTION (1.73 Å) 主引用文献 Pyrrolidine carboxamides as a novel class of inhibitors of enoyl acyl carrier protein reductase from Mycobacterium tuberculosis J. Med. Chem., 2006
5YLL	Structure of GH113 beta-1,4-mannanase complex with M6. 分子名称: beta-1,4-mannanase, beta-D-mannopyranose-(1-4)-beta-D-mannopyranose-(1-4)-beta-D-mannopyranose 著者 Jiang, Z.Q, You, X, Yang, S.Q, Huang, P, Ma, J.W. 登録日 2017-10-17 公開日 2018-06-20 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (1.81 Å) 主引用文献 Structural insights into the catalytic mechanism of a novel glycoside hydrolase family 113 beta-1,4-mannanase from Amphibacillus xylanus J. Biol. Chem., 293, 2018
5YE8	The crystal structure of Lp-PLA2 in complex with a novel inhibitor 分子名称: N-[3,4-bis(fluoranyl)phenyl]methanesulfonamide, Platelet-activating factor acetylhydrolase 著者 Liu, Q.F, Xu, Y.C. 登録日 2017-09-15 公開日 2018-07-25 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (1.851 Å) 主引用文献 Structure-Guided Discovery of Novel, Potent, and Orally Bioavailable Inhibitors of Lipoprotein-Associated Phospholipase A2. J. Med. Chem., 60, 2017
5Y3C	Crystal structure of zebrafish Ccd1 DIX domain 分子名称: Dixin-A 著者 Terawaki, S, Shibata, N, Higuchi, Y. 登録日 2017-07-28 公開日 2017-09-06 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (1.96 Å) 主引用文献 Structural basis for Ccd1 auto-inhibition in the Wnt pathway through homomerization of the DIX domain. Sci Rep, 7, 2017
5YQJ	Crystal structure of the first StARkin domain of Lam4 分子名称: Membrane-anchored lipid-binding protein LAM4 著者 Im, Y.J, Tong, J.S. 登録日 2017-11-06 公開日 2018-01-31 最終更新日 2024-03-27 実験手法 X-RAY DIFFRACTION (1.5 Å) 主引用文献 Structural basis of sterol recognition and nonvesicular transport by lipid transfer proteins anchored at membrane contact sites Proc. Natl. Acad. Sci. U.S.A., 115, 2018
4TQI	Human transthyretin (TTR) complexed with 3-(9H-fluoren-9-ylideneaminooxy)propanoic acid in a dual binding mode 分子名称: (2S)-3-[(9H-fluoren-9-ylideneamino)oxy]-2-methylpropanoic acid, GLYCEROL, Transthyretin 著者 Stura, E.A, Ciccone, L, Nencetti, S, Rossello, A, Orlandini, E. 登録日 2014-06-11 公開日 2015-06-24 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (1.25 Å) 主引用文献 X-ray crystal structure and activity of fluorenyl-based compounds as transthyretin fibrillogenesis inhibitors. J Enzyme Inhib Med Chem, 2015
4S2X	Structure of E. coli RppH bound to RNA and two magnesium ions 分子名称: MAGNESIUM ION, RNA (5'-R(*(APC)*GP*U)-3'), RNA pyrophosphohydrolase, ... 著者 Vasilyev, N, Serganov, A. 登録日 2015-01-23 公開日 2015-02-11 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.5 Å) 主引用文献 Structures of RNA Complexes with the Escherichia coli RNA Pyrophosphohydrolase RppH Unveil the Basis for Specific 5'-End-dependent mRNA Decay. J.Biol.Chem., 290, 2015
4TT9	Structure of the C-terminal SpoA domain of Shigella flexneri Spa33 分子名称: 1,2-ETHANEDIOL, Surface presentation of antigens protein SpaO 著者 McDowell, M.A, Johnson, S, Lea, S.M. 登録日 2014-06-20 公開日 2015-06-24 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Characterisation of Shigella Spa33 and Thermotoga FliM/N reveals a new model for C-ring assembly in T3SS. Mol.Microbiol., 99, 2016
5Y3B	Crystal structure of mouse Ccd1 DIX domain 分子名称: Dixin 著者 Terawaki, S, Shibata, N, Higuchi, Y. 登録日 2017-07-28 公開日 2017-09-06 最終更新日 2024-03-27 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 Structural basis for Ccd1 auto-inhibition in the Wnt pathway through homomerization of the DIX domain. Sci Rep, 7, 2017
4RKG	Structure of the MSL2 CXC domain bound with a non-specific (GC)6 DNA 分子名称: DNA (5'-D(*GP*CP*GP*CP*GP*CP*GP*CP*GP*CP*GP*C)-3'), E3 ubiquitin-protein ligase msl-2, ZINC ION 著者 Zheng, S, Ye, K. 登録日 2014-10-13 公開日 2015-01-21 最終更新日 2024-05-01 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Structural basis of X chromosome DNA recognition by the MSL2 CXC domain during Drosophila dosage compensation. Genes Dev., 28, 2014
5YEA	The crystal structure of Lp-PLA2 in complex with a novel inhibitor 分子名称: 4-[[4-[4-chloranyl-3-(trifluoromethyl)phenoxy]-3-cyano-phenyl]sulfamoyl]benzoic acid, Platelet-activating factor acetylhydrolase, SULFATE ION 著者 Liu, Q.F, Xu, Y.C. 登録日 2017-09-15 公開日 2018-07-25 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (1.805 Å) 主引用文献 Structure-Guided Discovery of Novel, Potent, and Orally Bioavailable Inhibitors of Lipoprotein-Associated Phospholipase A2. J. Med. Chem., 60, 2017
5YLI	Complex structure of GH113 beta-1,4-mannanase 分子名称: beta-1,4-mannanas, beta-D-mannopyranose-(1-4)-beta-D-mannopyranose-(1-4)-beta-D-mannopyranose-(1-4)-beta-D-mannopyranose 著者 Jiang, Z.Q, You, X, Yang, S.Q, Huang, P, Ma, J.W. 登録日 2017-10-17 公開日 2018-06-20 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2.37 Å) 主引用文献 Structural insights into the catalytic mechanism of a novel glycoside hydrolase family 113 beta-1,4-mannanase from Amphibacillus xylanus J. Biol. Chem., 293, 2018
4RVE	THE CRYSTAL STRUCTURE OF ECORV ENDONUCLEASE AND OF ITS COMPLEXES WITH COGNATE AND NON-COGNATE DNA SEGMENTS 分子名称: DNA (5'-D(*GP*GP*GP*AP*TP*AP*TP*CP*CP*C)-3'), PROTEIN (ECO RV (E.C.3.1.21.4)) 著者 Winkler, F.K, Banner, D.W, Oefner, C, Tsernoglou, D, Brown, R.S, Heathman, S.P, Bryan, R.K, Martin, P.D, Petratos, K, Wilso, K.S. 登録日 1993-02-18 公開日 1993-04-15 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 The crystal structure of EcoRV endonuclease and of its complexes with cognate and non-cognate DNA fragments. EMBO J., 12, 1993
4RZL	DNA recognition domain of the cytosine modification-dependent restriction endonuclease LpnPI 分子名称: PENTAETHYLENE GLYCOL, Restriction endonuclease LpnPI 著者 Sasnauskas, G, Tamulaitiene, G, Siksnys, V. 登録日 2014-12-22 公開日 2015-06-10 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Structure-guided sequence specificity engineering of the modification-dependent restriction endonuclease LpnPI. Nucleic Acids Res., 43, 2015

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