5Y9T

Crystal Structure of EGFR T790M mutant in complex with naquotinib

Summary for 5Y9T

Entry DOI	10.2210/pdb5y9t/pdb
Descriptor	Epidermal growth factor receptor, 6-ethyl-3-[[4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]phenyl]amino]-5-[(3R)-1-prop-2-enoylpyrrolidin-3-yl]oxy-pyrazin e-2-carboxamide (2 entities in total)
Functional Keywords	kinase, transferase
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	38468.55
Authors	Mimasu, S.,Tomimoto, Y.,Maiko, I.,Yasushi, A.,Tatsuya, N. (deposition date: 2017-08-28, release date: 2018-07-11, Last modification date: 2023-11-22)
Primary citation	Hirano, T.,Yasuda, H.,Hamamoto, J.,Nukaga, S.,Masuzawa, K.,Kawada, I.,Naoki, K.,Niimi, T.,Mimasu, S.,Sakagami, H.,Soejima, K.,Betsuyaku, T. Pharmacological and Structural Characterizations of Naquotinib, a Novel Third-Generation EGFR Tyrosine Kinase Inhibitor, inEGFR-Mutated Non-Small Cell Lung Cancer. Mol. Cancer Ther., 17:740-750, 2018 Cited by PubMed: 29467275 DOI: 10.1158/1535-7163.MCT-17-1033 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.25 Å)

Structure validation