Structure of the MSL2 CXC domain bound with a non-specific (GC)6 DNA

Summary for 4RKG

DescriptorE3 ubiquitin-protein ligase msl-2, DNA (5'-D(*GP*CP*GP*CP*GP*CP*GP*CP*GP*CP*GP*C)-3'), ZINC ION (3 entities in total)
Functional Keywordszinc cluster, dna binding domain, dosage compensation, dna binding protein-dna complex, dna binding protein/dna
Biological sourceDrosophila melanogaster (Fruit fly)
Cellular locationNucleus P50534
Total number of polymer chains4
Total molecular weight19224.42
Zheng, S.,Ye, K. (deposition date: 2014-10-13, release date: 2015-01-21)
Primary citation
Zheng, S.,Villa, R.,Wang, J.,Feng, Y.,Wang, J.,Becker, P.B.,Ye, K.
Structural basis of X chromosome DNA recognition by the MSL2 CXC domain during Drosophila dosage compensation.
Genes Dev., 28:2652-2662, 2014
PubMed: 25452275 (PDB entries with the same primary citation)
DOI: 10.1101/gad.250936.114
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.314506.8%3.7%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation reportDownload
PDB entries from 2020-08-05