PDB: 8861 件ウェブページステータス検索Chemie searchBIRD

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4IL1	Crystal Structure of the Rat Calcineurin 分子名称: CALCIUM ION, Calmodulin, Calcineurin subunit B type 1, ... 著者 Ye, Q, Faucher, F, Jia, Z. 登録日 2012-12-28 公開日 2013-10-02 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 Structural basis of calcineurin activation by calmodulin. Cell Signal, 25, 2013
3UIN	Complex between human RanGAP1-SUMO2, UBC9 and the IR1 domain from RanBP2 分子名称: E3 SUMO-protein ligase RanBP2, Ran GTPase-activating protein 1, SUMO-conjugating enzyme UBC9, ... 著者 Gareau, J.R, Reverter, D, Lima, C.D. 登録日 2011-11-05 公開日 2011-12-28 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (2.597 Å) 主引用文献 Determinants of small ubiquitin-like modifier 1 (SUMO1) protein specificity, E3 ligase, and SUMO-RanGAP1 binding activities of nucleoporin RanBP2. J.Biol.Chem., 287, 2012
4MDF	Structure of bacterial polynucleotide kinase Michaelis complex bound to GTP and DNA 分子名称: CITRIC ACID, DNA (5'-D(*CP*CP*TP*GP*T)-3'), GUANOSINE-5'-TRIPHOSPHATE, ... 著者 Shuman, S, Das, U, Wang, L.K, Smith, P, Jacewicz, A. 登録日 2013-08-22 公開日 2013-11-06 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (1.727 Å) 主引用文献 Structures of bacterial polynucleotide kinase in a Michaelis complex with GTP*Mg2+ and 5'-OH oligonucleotide and a product complex with GDP*Mg2+ and 5'-PO4 oligonucleotide reveal a mechanism of general acid-base catalysis and the determinants of phosphoacceptor recognition. Nucleic Acids Res., 42, 2014
4I5H	Crystal Structure of a Double Mutant Rat Erk2 Complexed With a Type II Quinazoline Inhibitor 分子名称: Mitogen-activated protein kinase 1, N-{3-[2-(cyclopropylamino)quinazolin-6-yl]-4-methylphenyl}-3-(trifluoromethyl)benzamide 著者 Hari, S.B, Maly, D.J, Merritt, E.A. 登録日 2012-11-28 公開日 2013-07-10 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Sequence determinants of a specific inactive protein kinase conformation. Chem.Biol., 20, 2013
6OEV	Structure of human Patched1 in complex with native Sonic Hedgehog 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Protein patched homolog 1, ... 著者 Qi, X, Li, X. 登録日 2019-03-27 公開日 2019-04-17 最終更新日 2020-07-29 実験手法 ELECTRON MICROSCOPY (3.8 Å) 主引用文献 Structures of human Patched and its complex with native palmitoylated sonic hedgehog. Nature, 560, 2018
4OGR	crystal structure of P-TEFb complex with AFF4 and Tat 分子名称: ADENOSINE, AF4/FMR2 family member 4, Cyclin-T1, ... 著者 Schulze-Gahmen, U, Alber, T. 登録日 2014-01-16 公開日 2014-05-07 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 AFF4 binding to Tat-P-TEFb indirectly stimulates TAR recognition of super elongation complexes at the HIV promoter. Elife, 3, 2014
6OEU	Structure of human Patched1 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Protein patched homolog 1 著者 Qi, X, Li, X, Wang, J. 登録日 2019-03-27 公開日 2019-04-10 最終更新日 2024-03-13 実験手法 ELECTRON MICROSCOPY (3.5 Å) 主引用文献 Structures of human Patched and its complex with native palmitoylated sonic hedgehog. Nature, 560, 2018
4DFX	Crystal structure of myristoylated K7C catalytic subunit of cAMP-dependent protein kinase in complex with SP20 and AMP-PNP 分子名称: GLYCEROL, MAGNESIUM ION, MYRISTIC ACID, ... 著者 Bastidas, A.C, Steichen, J.M, Taylor, S.S. 登録日 2012-01-24 公開日 2012-06-06 最終更新日 2013-01-02 実験手法 X-RAY DIFFRACTION (1.35 Å) 主引用文献 Role of N-terminal myristylation in the structure and regulation of cAMP-dependent protein kinase. J.Mol.Biol., 422, 2012
4DG2	Crystal structure of myristoylated WT catalytic subunit of cAMP-dependent protein kinase in complex with SP20 分子名称: MYRISTIC ACID, cAMP-dependent protein kinase catalytic subunit alpha, cAMP-dependent protein kinase inhibitor alpha 著者 Bastidas, A.C, Steichen, J.M, Taylor, S.S. 登録日 2012-01-24 公開日 2012-06-06 最終更新日 2013-01-02 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Role of N-terminal myristylation in the structure and regulation of cAMP-dependent protein kinase. J.Mol.Biol., 422, 2012
7MXN	PRMT5(M420T mutant):MEP50 complexed with inhibitor PF-06939999 分子名称: (1S,2S,3S,5R)-3-{[6-(difluoromethyl)-5-fluoro-1,2,3,4-tetrahydroisoquinolin-8-yl]oxy}-5-(4-methyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)cyclopentane-1,2-diol, Methylosome protein 50, Protein arginine N-methyltransferase 5 著者 McTigue, M, Deng, Y.L, Liu, W, Brooun, A. 登録日 2021-05-19 公開日 2021-11-17 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.55 Å) 主引用文献 SAM-Competitive PRMT5 Inhibitor PF-06939999 Demonstrates Antitumor Activity in Splicing Dysregulated NSCLC with Decreased Liability of Drug Resistance. Mol.Cancer Ther., 21, 2022
7MX7	PRMT5:MEP50 complexed with inhibitor PF-06939999 分子名称: (1S,2S,3S,5R)-3-{[6-(difluoromethyl)-5-fluoro-1,2,3,4-tetrahydroisoquinolin-8-yl]oxy}-5-(4-methyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)cyclopentane-1,2-diol, Methylosome protein 50, Protein arginine N-methyltransferase 5 著者 McTigue, M, Deng, Y.L, Liu, W, Brooun, A. 登録日 2021-05-18 公開日 2021-11-17 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.49 Å) 主引用文献 SAM-Competitive PRMT5 Inhibitor PF-06939999 Demonstrates Antitumor Activity in Splicing Dysregulated NSCLC with Decreased Liability of Drug Resistance. Mol.Cancer Ther., 21, 2022
1GOL	COORDINATES OF RAT MAP KINASE ERK2 WITH AN ARGININE MUTATION AT POSITION 52 分子名称: ADENOSINE-5'-TRIPHOSPHATE, EXTRACELLULAR REGULATED KINASE 2, MAGNESIUM ION 著者 Harkins, P.C, Zhang, F, Goldsmith, E.J. 登録日 1996-01-23 公開日 1997-03-12 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Mutation of position 52 in ERK2 creates a nonproductive binding mode for adenosine 5'-triphosphate. Biochemistry, 35, 1996
7MXA	PRMT5:MEP50 complexed with inhibitor PF-06855800 分子名称: 7-[(5R)-5-C-(4-chloro-3-fluorophenyl)-beta-D-ribofuranosyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine, Methylosome protein 50, Protein arginine N-methyltransferase 5 著者 McTigue, M, Deng, Y.L, Liu, W, Brooun, A. 登録日 2021-05-18 公開日 2021-11-17 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.713 Å) 主引用文献 SAM-Competitive PRMT5 Inhibitor PF-06939999 Demonstrates Antitumor Activity in Splicing Dysregulated NSCLC with Decreased Liability of Drug Resistance. Mol.Cancer Ther., 21, 2022
5KKL	Structure of ctPRC2 in complex with H3K27me3 and H3K27M 分子名称: ALA-ALA-ARG-M3L-SER-ALA-PRO-ALA, Putative uncharacterized protein,Histone H3.1 peptide,Zinc finger domain-containing protein, S-ADENOSYLMETHIONINE, ... 著者 Jiao, L, Liu, X. 登録日 2016-06-21 公開日 2017-04-19 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2.94 Å) 主引用文献 Response to Comment on "Structural basis of histone H3K27 trimethylation by an active polycomb repressive complex 2". Science, 354, 2016
7MXG	PRMT5(M420T mutant):MEP50 complexed with inhibitor PF-06855800 分子名称: 7-[(5R)-5-C-(4-chloro-3-fluorophenyl)-beta-D-ribofuranosyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine, Methylosome protein 50, Protein arginine N-methyltransferase 5 著者 McTigue, M, Deng, Y.L, Liu, W, Brooun, A. 登録日 2021-05-19 公開日 2021-11-17 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.395 Å) 主引用文献 SAM-Competitive PRMT5 Inhibitor PF-06939999 Demonstrates Antitumor Activity in Splicing Dysregulated NSCLC with Decreased Liability of Drug Resistance. Mol.Cancer Ther., 21, 2022
7MXC	PRMT5:MEP50 complexed with adenosine 分子名称: ADENOSINE, Methylosome protein 50, Protein arginine N-methyltransferase 5 著者 McTigue, M, Deng, Y.L, Liu, W, Brooun, A. 登録日 2021-05-18 公開日 2021-11-17 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.41 Å) 主引用文献 SAM-Competitive PRMT5 Inhibitor PF-06939999 Demonstrates Antitumor Activity in Splicing Dysregulated NSCLC with Decreased Liability of Drug Resistance. Mol.Cancer Ther., 21, 2022
1ZQ3	NMR Solution Structure of the Bicoid Homeodomain Bound to the Consensus DNA Binding Site TAATCC 分子名称: 5'-D(*CP*GP*GP*GP*GP*AP*TP*TP*AP*GP*AP*GP*C)-3', 5'-D(*GP*CP*TP*CP*TP*AP*AP*TP*CP*CP*CP*CP*G)-3', Homeotic bicoid protein 著者 Baird-Titus, J.M, Rance, M, Clark-Baldwin, K, Ma, J, Vrushank, D. 登録日 2005-05-18 公開日 2006-02-14 最終更新日 2024-05-22 実験手法 SOLUTION NMR 主引用文献 The solution structure of the native K50 Bicoid homeodomain bound to the consensus TAATCC DNA-binding site. J.Mol.Biol., 356, 2006
4DFZ	Crystal structure of myristoylated K7C catalytic subunit of cAMP-dependent protein kinase in complex with SP20 分子名称: MYRISTIC ACID, cAMP-dependent protein kinase catalytic subunit alpha, cAMP-dependent protein kinase inhibitor alpha 著者 Bastidas, A.C, Steichen, J.M, Taylor, S.S. 登録日 2012-01-24 公開日 2012-06-06 最終更新日 2013-01-02 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Role of N-terminal myristylation in the structure and regulation of cAMP-dependent protein kinase. J.Mol.Biol., 422, 2012
4DG0	Crystal structure of myristoylated WT catalytic subunit of cAMP-dependent protein kinase in complex with SP20 and AMP-PNP 分子名称: MAGNESIUM ION, MYRISTIC ACID, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ... 著者 Bastidas, A.C, Steichen, J.M, Taylor, S.S. 登録日 2012-01-24 公開日 2012-06-06 最終更新日 2013-01-02 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Role of N-terminal myristylation in the structure and regulation of cAMP-dependent protein kinase. J.Mol.Biol., 422, 2012
1M4U	Crystal structure of Bone Morphogenetic Protein-7 (BMP-7) in complex with the secreted antagonist Noggin 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Bone Morphogenetic Protein-7, Noggin 著者 Groppe, J, Greenwald, J, Wiater, E, Rodriguez-Leon, J, Economides, A.N, Kwiatkowski, W, Affolter, M, Vale, W.W, Izpisua-Belmonte, J.C, Choe, S. 登録日 2002-07-03 公開日 2002-12-18 最終更新日 2022-12-21 実験手法 X-RAY DIFFRACTION (2.42 Å) 主引用文献 Structural Basis of BMP Signalling Inhibition by the Cystine Knot Protein Noggin Nature, 420, 2002
4MDE	Structure of bacterial polynucleotide kinase product complex bound to GDP and DNA 分子名称: DNA (5'-D(P*CP*CP*TP*GP*T)-3'), GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... 著者 Shuman, S, Das, U, Wang, L.K, Smith, P, Jacewicz, A. 登録日 2013-08-22 公開日 2013-11-06 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Structures of bacterial polynucleotide kinase in a Michaelis complex with GTP*Mg2+ and 5'-OH oligonucleotide and a product complex with GDP*Mg2+ and 5'-PO4 oligonucleotide reveal a mechanism of general acid-base catalysis and the determinants of phosphoacceptor recognition. Nucleic Acids Res., 42, 2014
4NAC	Crystal Structure of the N-terminal Domain of p15RS 分子名称: Regulation of nuclear pre-mRNA domain-containing protein 1A 著者 Mei, K, Jin, Z, Ren, F, Wang, Y. 登録日 2013-10-22 公開日 2013-12-11 最終更新日 2024-03-20 実験手法 X-RAY DIFFRACTION (2.002 Å) 主引用文献 Crystal Structure of the N-terminal Domain of p15RS To be Published
3MU6	Inhibiting the Binding of Class IIa Histone Deacetylases to Myocyte Enhancer Factor-2 by Small Molecules 分子名称: (3E)-N~8~-(2-aminophenyl)-N~1~-phenyloct-3-enediamide, DNA (5'-D(*AP*AP*AP*GP*CP*TP*AP*TP*TP*AP*TP*TP*AP*GP*CP*TP*T)-3'), DNA (5'-D(*TP*AP*AP*GP*CP*TP*AP*AP*TP*AP*AP*TP*AP*GP*CP*TP*T)-3'), ... 著者 Jayathilaka, N, Han, A, Gaffney, K, Dey, R, He, J, Ye, J, Gao, T, Petasis, N.A, Chen, L. 登録日 2010-05-01 公開日 2011-11-02 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2.434 Å) 主引用文献 Inhibition of the function of class IIa HDACs by blocking their interaction with MEF2. Nucleic Acids Res., 40, 2012
5FP6	Structure of cyclin-dependent kinase 2 with small-molecule ligand 3-(4,7-dichloro-1H-indol-3-yl)prop-2-yn-1-ol (AT17833) in an alternate binding site. 分子名称: 3-(4,7-dichloro-1H-indol-3-yl)prop-2-yn-1-ol, CYCLIN-DEPENDENT KINASE 2 著者 Jhoti, H, Ludlow, R.F, O'Reilly, M, Saini, H.K, Tickle, I.J, Verdonk, M. 登録日 2015-11-27 公開日 2015-12-23 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.85 Å) 主引用文献 Detection of Secondary Binding Sites in Proteins Using Fragment Screening. Proc.Natl.Acad.Sci.USA, 112, 2015
8CYV	CryoEM structures of amplified alpha-synuclein fibril class B mixed type I/II with extended core from DLB case II 分子名称: Alpha-synuclein 著者 Zhou, Y, Sokratian, A, Xu, E, Viverette, E, Dillard, L, Yuan, Y, Li, J.Y, Matarangas, A, Bouvette, J, Borgnia, M, Bartesaghi, A, West, A. 登録日 2022-05-24 公開日 2023-05-31 最終更新日 2024-06-12 実験手法 ELECTRON MICROSCOPY (3.5 Å) 主引用文献 Structural and functional landscape of alpha-synuclein fibril assemblies amplified from cerebrospinal fluid To Be Published

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