4I5H
Crystal Structure of a Double Mutant Rat Erk2 Complexed With a Type II Quinazoline Inhibitor
Summary for 4I5H
| Entry DOI | 10.2210/pdb4i5h/pdb |
| Descriptor | Mitogen-activated protein kinase 1, N-{3-[2-(cyclopropylamino)quinazolin-6-yl]-4-methylphenyl}-3-(trifluoromethyl)benzamide (3 entities in total) |
| Functional Keywords | map kinase, dfg-out, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
| Biological source | Rattus norvegicus (brown rat,rat,rats) |
| Cellular location | Cytoplasm, cytoskeleton, spindle (By similarity): P63086 |
| Total number of polymer chains | 1 |
| Total formula weight | 41815.97 |
| Authors | Hari, S.B.,Maly, D.J.,Merritt, E.A. (deposition date: 2012-11-28, release date: 2013-07-10, Last modification date: 2024-02-28) |
| Primary citation | Hari, S.B.,Merritt, E.A.,Maly, D.J. Sequence determinants of a specific inactive protein kinase conformation. Chem.Biol., 20:806-815, 2013 Cited by PubMed: 23790491DOI: 10.1016/j.chembiol.2013.05.005 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.9 Å) |
Structure validation
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