4I5H
Crystal Structure of a Double Mutant Rat Erk2 Complexed With a Type II Quinazoline Inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Mitogen-activated protein kinase 1 | polymer | 359 | 41353.5 | 1 | UniProt (P63086) Pfam (PF00069) | Rattus norvegicus (brown rat rat rats) | MAP kinase 1, MAPK 1, ERT1, Extracellular signal-regulated kinase 2, ERK-2, MAP kinase isoform p42, p42-MAPK, Mitogen-activated protein kinase 2, MAP kinase 2, MAPK 2 |
| 2 | B (A) | N-{3-[2-(cyclopropylamino)quinazolin-6-yl]-4-methylphenyl}-3-(trifluoromethyl)benzamide | non-polymer | 462.5 | 1 | Chemie (G17) | |||
| 3 | C (A) | water | water | 18.0 | 134 | Chemie (HOH) |
Sequence modifications
A: 2 - 358 (UniProt: P63086)
| PDB | External Database | Details |
|---|---|---|
| Ser 0 | - | expression tag |
| Asn 1 | - | expression tag |
| Ala 103 | Gln 103 | engineered mutation |
| Leu 164 | Cys 164 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 41353.5 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 462.5 | |
| All* | Total formula weight | 41816.0 |
