5FP6
Structure of cyclin-dependent kinase 2 with small-molecule ligand 3-(4,7-dichloro-1H-indol-3-yl)prop-2-yn-1-ol (AT17833) in an alternate binding site.
Summary for 5FP6
| Entry DOI | 10.2210/pdb5fp6/pdb |
| Related | 5FP5 5FPD 5FPE 5FPM 5FPN 5FPO 5FPR 5FPS 5FPT 5FPY |
| Descriptor | CYCLIN-DEPENDENT KINASE 2, 3-(4,7-dichloro-1H-indol-3-yl)prop-2-yn-1-ol (3 entities in total) |
| Functional Keywords | transferase, kinase, mitosis, cell cycle, fragment screening, alternate binding site. |
| Biological source | HOMO SAPIENS (HUMAN) |
| Cellular location | Cytoplasm, cytoskeleton, microtubule organizing center, centrosome: P24941 |
| Total number of polymer chains | 1 |
| Total formula weight | 34456.66 |
| Authors | Jhoti, H.,Ludlow, R.F.,O'Reilly, M.,Saini, H.K.,Tickle, I.J.,Verdonk, M. (deposition date: 2015-11-27, release date: 2015-12-23, Last modification date: 2024-01-10) |
| Primary citation | Ludlow, R.F.,Verdonk, M.L.,Saini, H.K.,Tickle, I.J.,Jhoti, H. Detection of Secondary Binding Sites in Proteins Using Fragment Screening. Proc.Natl.Acad.Sci.USA, 112:15910-, 2015 Cited by PubMed: 26655740DOI: 10.1073/PNAS.1518946112 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.85 Å) |
Structure validation
Download full validation report
