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3MU6

Inhibiting the Binding of Class IIa Histone Deacetylases to Myocyte Enhancer Factor-2 by Small Molecules

Summary for 3MU6
Entry DOI10.2210/pdb3mu6/pdb
DescriptorMyocyte-specific enhancer factor 2A, DNA (5'-D(*AP*AP*AP*GP*CP*TP*AP*TP*TP*AP*TP*TP*AP*GP*CP*TP*T)-3'), DNA (5'-D(*TP*AP*AP*GP*CP*TP*AP*AP*TP*AP*AP*TP*AP*GP*CP*TP*T)-3'), ... (4 entities in total)
Functional Keywordsmads-box/mef2 domain, transcription co-factors, protein-dna complex, protein-protein docking, dna binding protein-dna complex, dna binding protein/dna
Biological sourceHomo sapiens (human)
Cellular locationNucleus : Q02078
Total number of polymer chains8
Total formula weight54768.84
Authors
Jayathilaka, N.,Han, A.,Gaffney, K.,Dey, R.,He, J.,Ye, J.,Gao, T.,Petasis, N.A.,Chen, L. (deposition date: 2010-05-01, release date: 2011-11-02, Last modification date: 2023-09-06)
Primary citationJayathilaka, N.,Han, A.,Gaffney, K.J.,Dey, R.,Jarusiewicz, J.A.,Noridomi, K.,Philips, M.A.,Lei, X.,He, J.,Ye, J.,Gao, T.,Petasis, N.A.,Chen, L.
Inhibition of the function of class IIa HDACs by blocking their interaction with MEF2.
Nucleic Acids Res., 40:5378-5388, 2012
Cited by
PubMed: 22396528
DOI: 10.1093/nar/gks189
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.434 Å)
Structure validation

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