Inhibiting the Binding of Class IIa Histone Deacetylases to Myocyte Enhancer Factor-2 by Small Molecules

Summary for 3MU6

DescriptorMyocyte-specific enhancer factor 2A, DNA (5'-D(*AP*AP*AP*GP*CP*TP*AP*TP*TP*AP*TP*TP*AP*GP*CP*TP*T)-3'), DNA (5'-D(*TP*AP*AP*GP*CP*TP*AP*AP*TP*AP*AP*TP*AP*GP*CP*TP*T)-3'), ... (4 entities in total)
Functional Keywordsmads-box/mef2 domain, transcription co-factors, protein-dna complex, protein-protein docking, dna binding protein-dna complex, dna binding protein/dna
Biological sourceHomo sapiens (human)
Cellular locationNucleus  Q02078
Total number of polymer chains8
Total molecular weight54768.84
Jayathilaka, N.,Han, A.,Gaffney, K.,Dey, R.,He, J.,Ye, J.,Gao, T.,Petasis, N.A.,Chen, L. (deposition date: 2010-05-01, release date: 2011-11-02, Last modification date: 2017-11-08)
Primary citation
Jayathilaka, N.,Han, A.,Gaffney, K.J.,Dey, R.,Jarusiewicz, J.A.,Noridomi, K.,Philips, M.A.,Lei, X.,He, J.,Ye, J.,Gao, T.,Petasis, N.A.,Chen, L.
Inhibition of the function of class IIa HDACs by blocking their interaction with MEF2.
Nucleic Acids Res., 40:5378-5388, 2012
PubMed: 22396528 (PDB entries with the same primary citation)
DOI: 10.1093/nar/gks189
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.23670 3.5% 0.6%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
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PDB entries from 2020-12-02