3MU6
Inhibiting the Binding of Class IIa Histone Deacetylases to Myocyte Enhancer Factor-2 by Small Molecules
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, E, F (A, B, C, D) | Myocyte-specific enhancer factor 2A | polymer | 71 | 8402.9 | 4 | UniProt (Q02078) Pfam (PF00319) | Homo sapiens (human) | Serum response factor-like protein 1 |
| 2 | C, G (E, G) | DNA (5'-D(*AP*AP*AP*GP*CP*TP*AP*TP*TP*AP*TP*TP*AP*GP*CP*TP*T)-3') | polymer | 17 | 5200.4 | 2 | |||
| 3 | D, H (F, H) | DNA (5'-D(*TP*AP*AP*GP*CP*TP*AP*AP*TP*AP*AP*TP*AP*GP*CP*TP*T)-3') | polymer | 17 | 5209.4 | 2 | |||
| 4 | I (A) | (3E)-N~8~-(2-aminophenyl)-N~1~-phenyloct-3-enediamide | non-polymer | 337.4 | 1 | Chemie (BXL) |
Sequence modifications
A, B, C, D: 2 - 72 (UniProt: Q02078)
| PDB | External Database | Details |
|---|---|---|
| Ala 71 | Glu 71 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 8 |
| Total formula weight | 54431.4 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 337.4 | |
| All* | Total formula weight | 54768.8 |
