3MU6

Inhibiting the Binding of Class IIa Histone Deacetylases to Myocyte Enhancer Factor-2 by Small Molecules

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000977	molecular_function	RNA polymerase II transcription regulatory region sequence-specific DNA binding
A	0003677	molecular_function	DNA binding
A	0045944	biological_process	positive regulation of transcription by RNA polymerase II
A	0046983	molecular_function	protein dimerization activity
B	0000977	molecular_function	RNA polymerase II transcription regulatory region sequence-specific DNA binding
B	0003677	molecular_function	DNA binding
B	0045944	biological_process	positive regulation of transcription by RNA polymerase II
B	0046983	molecular_function	protein dimerization activity
C	0000977	molecular_function	RNA polymerase II transcription regulatory region sequence-specific DNA binding
C	0003677	molecular_function	DNA binding
C	0045944	biological_process	positive regulation of transcription by RNA polymerase II
C	0046983	molecular_function	protein dimerization activity
D	0000977	molecular_function	RNA polymerase II transcription regulatory region sequence-specific DNA binding
D	0003677	molecular_function	DNA binding
D	0045944	biological_process	positive regulation of transcription by RNA polymerase II
D	0046983	molecular_function	protein dimerization activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	11
Details	BINDING SITE FOR RESIDUE BXL A 100

Chain	Residue
A	ASP61
B	THR70
G	DT17
A	MET62
A	ASP63
A	LEU66
A	LEU67
A	THR70
B	LEU66
B	LEU67
B	TYR69

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Functional Information from PROSITE/UniProt

site_id	PS00350
Number of Residues	55
Details	MADS_BOX_1 MADS-box domain signature. RkKiqitrImDernRqvTFtKRKfgLmKKAyELSvLcdceIaLIIfnssnkLfqY

Chain	Residue	Details
A	ARG3-TYR57

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	MOD_RES: Phosphoserine; by CK2 => ECO:0000250

Chain	Residue	Details
A	SER59
B	SER59
C	SER59
D	SER59

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