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4OGR

crystal structure of P-TEFb complex with AFF4 and Tat

Summary for 4OGR
Entry DOI10.2210/pdb4ogr/pdb
DescriptorCyclin-dependent kinase 9, Cyclin-T1, AF4/FMR2 family member 4, ... (7 entities in total)
Functional Keywordsp-tefb, cyclin-dependent kinase 9, cyclin fold, intrinsically unstructured aff4, transcriptional regulation at hiv promoter, binds tar, n-terminal acetylation of tat, transferase-viral protein complex, transferase/viral protein
Biological sourceHomo sapiens (human)
More
Cellular locationNucleus: P50750 O60563 Q9UHB7
Host nucleus, host nucleolus : P69698
Total number of polymer chains12
Total formula weight254451.64
Authors
Schulze-Gahmen, U.,Alber, T. (deposition date: 2014-01-16, release date: 2014-05-07, Last modification date: 2023-09-20)
Primary citationSchulze-Gahmen, U.,Lu, H.,Zhou, Q.,Alber, T.
AFF4 binding to Tat-P-TEFb indirectly stimulates TAR recognition of super elongation complexes at the HIV promoter.
Elife, 3:e02375-e02375, 2014
Cited by
PubMed: 24843025
DOI: 10.7554/eLife.02375
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (3 Å)
Structure validation

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