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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

4OGR

crystal structure of P-TEFb complex with AFF4 and Tat

Functional Information from GO Data
ChainGOidnamespacecontents
A0004672molecular_functionprotein kinase activity
A0005524molecular_functionATP binding
A0006468biological_processprotein phosphorylation
B0006357biological_processregulation of transcription by RNA polymerase II
B0016538molecular_functioncyclin-dependent protein serine/threonine kinase regulator activity
C0010468biological_processregulation of gene expression
D0001070molecular_functionRNA-binding transcription regulator activity
D0042025cellular_componenthost cell nucleus
D0050434biological_processpositive regulation of viral transcription
E0004672molecular_functionprotein kinase activity
E0005524molecular_functionATP binding
E0006468biological_processprotein phosphorylation
F0006357biological_processregulation of transcription by RNA polymerase II
F0016538molecular_functioncyclin-dependent protein serine/threonine kinase regulator activity
G0010468biological_processregulation of gene expression
H0001070molecular_functionRNA-binding transcription regulator activity
H0042025cellular_componenthost cell nucleus
H0050434biological_processpositive regulation of viral transcription
I0004672molecular_functionprotein kinase activity
I0005524molecular_functionATP binding
I0006468biological_processprotein phosphorylation
K0006357biological_processregulation of transcription by RNA polymerase II
K0016538molecular_functioncyclin-dependent protein serine/threonine kinase regulator activity
L0010468biological_processregulation of gene expression
M0001070molecular_functionRNA-binding transcription regulator activity
M0042025cellular_componenthost cell nucleus
M0050434biological_processpositive regulation of viral transcription
Functional Information from PDB Data
site_idAC1
Number of Residues7
DetailsBINDING SITE FOR RESIDUE ADN A 401
ChainResidue
AILE25
AGLY28
AALA46
APHE105
ACYS106
AASP109
AALA153
site_idAC2
Number of Residues8
DetailsBINDING SITE FOR RESIDUE ADN E 401
ChainResidue
EASP104
ECYS106
EASP109
EALA153
EASN154
ELEU156
EGLY26
EALA46
site_idAC3
Number of Residues10
DetailsBINDING SITE FOR RESIDUE ADN I 401
ChainResidue
IILE25
IGLY28
IALA46
IASP104
ICYS106
IASP109
IALA153
IASN154
ILEU156
IASP167
site_idAC4
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN D 101
ChainResidue
DCYS22
DHIS33
DCYS34
DCYS37
site_idAC5
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN D 102
ChainResidue
BCYS261
DCYS25
DCYS27
DCYS30
site_idAC6
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN H 101
ChainResidue
HCYS22
HHIS33
HCYS34
HCYS37
site_idAC7
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN H 102
ChainResidue
FCYS261
HCYS25
HCYS27
HCYS30
site_idAC8
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN M 101
ChainResidue
MCYS22
MHIS33
MCYS34
MCYS37
site_idAC9
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN M 102
ChainResidue
KCYS261
MCYS25
MCYS27
MCYS30
Functional Information from PROSITE/UniProt
site_idPS00107
Number of Residues24
DetailsPROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. IGQGTFGEVFkArhrktgqk..........VALK
ChainResidueDetails
AILE25-LYS48
site_idPS00108
Number of Residues13
DetailsPROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. IlHrDMKaaNVLI
ChainResidueDetails
AILE145-ILE157
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues3
DetailsActive site: {"description":"Proton acceptor","evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"},{"source":"PROSITE-ProRule","id":"PRU10027","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues16
DetailsBinding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues12
DetailsBinding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"18566585","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues3
DetailsModified residue: {"description":"N6-acetyllysine; by EP300/CBP, PCAF/KAT2B and GCN5/KAT2A","evidences":[{"source":"PubMed","id":"17452463","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18250157","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues3
DetailsModified residue: {"description":"N6-acetyllysine; by PCAF/KAT2B and GCN5/KAT2A","evidences":[{"source":"PubMed","id":"18250157","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28426094","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues3
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"21533037","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues3
DetailsModified residue: {"description":"Phosphothreonine; by CaMK1D","evidences":[{"source":"PubMed","id":"15965233","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18483222","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18566585","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18829461","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20535204","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20851342","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21448926","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21779453","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21406692","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues3
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18691976","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"19369195","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues3
DetailsModified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI10
Number of Residues3
DetailsSite: {"description":"Essential for interacting with HIV-1 Tat"}
ChainResidueDetails
site_idSWS_FT_FI11
Number of Residues3
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"19369195","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI12
Number of Residues69
DetailsRegion: {"description":"Interaction with human CREBBP","evidences":[{"source":"HAMAP-Rule","id":"MF_04079","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI13
Number of Residues45
DetailsRegion: {"description":"Cysteine-rich","evidences":[{"source":"HAMAP-Rule","id":"MF_04079","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI14
Number of Residues21
DetailsBinding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_04079","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI15
Number of Residues3
DetailsSite: {"description":"Essential for Tat translocation through the endosomal membrane","evidences":[{"source":"HAMAP-Rule","id":"MF_04079","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI16
Number of Residues3
DetailsModified residue: {"description":"N6-acetyllysine; by host PCAF","evidences":[{"source":"HAMAP-Rule","id":"MF_04079","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

246031

PDB entries from 2025-12-10

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