4OGR

crystal structure of P-TEFb complex with AFF4 and Tat

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, E, I	Cyclin-dependent kinase 9	polymer	332	38226.3	3	UniProt (P50750) Pfam (PF00069) In PDB	Homo sapiens (human)	C-2K, Cell division cycle 2-like protein kinase 4, Cell division protein kinase 9, Serine/threonine-protein kinase PITALRE, Tat-associated kinase complex catalytic subunit
2	B, F, K	Cyclin-T1	polymer	264	30619.0	3	UniProt (O60563) Pfam (PF00134) Pfam (PF21797) In PDB	Homo sapiens (human)	CycT1, Cyclin-T
3	C, G, L	AF4/FMR2 family member 4	polymer	75	8789.8	3	UniProt (Q9UHB7) In PDB	Homo sapiens (human)	ALL1-fused gene from chromosome 5q31 protein, Protein AF-5q31, Major CDK9 elongation factor-associated protein
4	D, H, M	Protein Tat	polymer	58	6784.1	3	UniProt (P69698) Pfam (PF00539) In PDB	Human immunodeficiency virus type 1 (HXB3 ISOLATE) (HIV-1)	Transactivating regulatory protein
5	A, E, I	ADENOSINE	non-polymer		267.2	3	Chemie (ADN)
6	D, H, M	ZINC ION	non-polymer		65.4	6	Chemie (ZN)
7		water	water		18.0	37	Chemie (HOH)

Sequence modifications

A, E, I: 1 - 330 (UniProt: P50750)

PDB	External Database	Details
Gly -1	-	expression tag
His 0	-	expression tag

C, G, L: 2 - 73 (UniProt: Q9UHB7)

PDB	External Database	Details
Ser -1	-	expression tag
Asn 0	-	expression tag
Ala 1	-	expression tag

D, H, M: 1 - 57 (UniProt: P69698)

PDB	External Database	Details
Ace 0	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	12
	Total formula weight	253257.5
Non-Polymers*	Number of molecules	9
	Total formula weight	1194.2
All*	Total formula weight	254451.6

*Water molecules are not included.