7MXN
PRMT5(M420T mutant):MEP50 complexed with inhibitor PF-06939999
Summary for 7MXN
Entry DOI | 10.2210/pdb7mxn/pdb |
Descriptor | Protein arginine N-methyltransferase 5, Methylosome protein 50, (1S,2S,3S,5R)-3-{[6-(difluoromethyl)-5-fluoro-1,2,3,4-tetrahydroisoquinolin-8-yl]oxy}-5-(4-methyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)cyclopentane-1,2-diol, ... (4 entities in total) |
Functional Keywords | arginine, methyl, transferase, transferase-transcription complex, transferase/transcription |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 2 |
Total formula weight | 112705.09 |
Authors | McTigue, M.,Deng, Y.L.,Liu, W.,Brooun, A. (deposition date: 2021-05-19, release date: 2021-11-17, Last modification date: 2023-10-18) |
Primary citation | Jensen-Pergakes, K.,Tatlock, J.,Maegley, K.A.,McAlpine, I.J.,McTigue, M.,Xie, T.,Dillon, C.P.,Wang, Y.,Yamazaki, S.,Spiegel, N.,Shi, M.,Nemeth, A.,Miller, N.,Hendrickson, E.,Lam, H.,Sherrill, J.,Chung, C.Y.,McMillan, E.A.,Bryant, S.K.,Palde, P.,Braganza, J.,Brooun, A.,Deng, Y.L.,Goshtasbi, V.,Kephart, S.E.,Kumpf, R.A.,Liu, W.,Patman, R.L.,Rui, E.,Scales, S.,Tran-Dube, M.,Wang, F.,Wythes, M.,Paul, T.A. SAM-Competitive PRMT5 Inhibitor PF-06939999 Demonstrates Antitumor Activity in Splicing Dysregulated NSCLC with Decreased Liability of Drug Resistance. Mol.Cancer Ther., 21:3-15, 2022 Cited by PubMed: 34737197DOI: 10.1158/1535-7163.MCT-21-0620 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.55 Å) |
Structure validation
Download full validation report