7MXN
PRMT5(M420T mutant):MEP50 complexed with inhibitor PF-06939999
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Protein arginine N-methyltransferase 5 | polymer | 637 | 72736.6 | 1 | UniProt (O14744) Pfam (PF17285) Pfam (PF05185) Pfam (PF17286) In PDB | Homo sapiens (Human) | PRMT5,72 kDa ICln-binding protein,Histone-arginine N-methyltransferase PRMT5,Jak-binding protein 1,Shk1 kinase-binding protein 1 homolog,SKB1 homolog,SKB1Hs |
2 | B | Methylosome protein 50 | polymer | 366 | 39520.1 | 1 | UniProt (Q9BQA1) Pfam (PF00400) In PDB | Homo sapiens (Human) | MEP-50,Androgen receptor cofactor p44,WD repeat-containing protein 77,p44/Mep50 |
3 | A | (1S,2S,3S,5R)-3-{[6-(difluoromethyl)-5-fluoro-1,2,3,4-tetrahydroisoquinolin-8-yl]oxy}-5-(4-methyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)cyclopentane-1,2-diol | non-polymer | 448.4 | 1 | Chemie (ZR1) | |||
4 | water | water | 18.0 | 237 | Chemie (HOH) |
Sequence modifications
A: 1 - 637 (UniProt: O14744)
B: 2 - 342 (UniProt: Q9BQA1)
PDB | External Database | Details |
---|---|---|
Thr 420 | Met 420 | engineered mutation |
PDB | External Database | Details |
---|---|---|
Met -23 | - | expression tag |
Ala -22 | - | expression tag |
Ser -21 | - | expression tag |
His -20 | - | expression tag |
His -19 | - | expression tag |
His -18 | - | expression tag |
His -17 | - | expression tag |
His -16 | - | expression tag |
His -15 | - | expression tag |
Asp -14 | - | expression tag |
Tyr -13 | - | expression tag |
Asp -12 | - | expression tag |
Gly -11 | - | expression tag |
Ala -10 | - | expression tag |
Thr -9 | - | expression tag |
Thr -8 | - | expression tag |
Glu -7 | - | expression tag |
Asn -6 | - | expression tag |
Leu -5 | - | expression tag |
Tyr -4 | - | expression tag |
Phe -3 | - | expression tag |
Gln -2 | - | expression tag |
Gly -1 | - | expression tag |
Ser 0 | - | expression tag |
Leu 1 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 112256.7 | |
Non-Polymers* | Number of molecules | 1 |
Total formula weight | 448.4 | |
All* | Total formula weight | 112705.1 |